Safety and efficacy of renal denervation utilizing standard bidirectional EP catheter: preliminary Vietnamese findings
Renal denervation (RDN) is a safe and effective treatment for hypertensive patients. However, data on its use with standard electrophysiology catheters, particularly from low- and middle-income countries, are limited. This study aimed to evaluate the acute safety and short-term efficacy of RDN in h...
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PAGEPress Publications
2024-11-01
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| Series: | Italian Journal of Medicine |
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| Online Access: | https://www.italjmed.org/ijm/article/view/1816 |
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| author | Tran Ba Hieu Nguyen Ngoc Quang Pham Manh Hung |
| author_facet | Tran Ba Hieu Nguyen Ngoc Quang Pham Manh Hung |
| author_sort | Tran Ba Hieu |
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Renal denervation (RDN) is a safe and effective treatment for hypertensive patients. However, data on its use with standard electrophysiology catheters, particularly from low- and middle-income countries, are limited. This study aimed to evaluate the acute safety and short-term efficacy of RDN in hypertensive patients using standard EP catheters from Vietnam. A prospective study was conducted from May 2023 to May 2024 at the Viet Nam National Heart Institute, Vietnam. A total of 22 patients (mean age 52.87±19.86 years, 12 male) with resistant hypertension underwent RDN by utilizing a standard bidirectional steerable radiofrequency (RF) ablation catheter with a 7 Fr diameter (Abbott, Chicago, IL, USA). Low-power RF applications have been applied along the length of both renal arteries. Renal ultrasound, blood tests, and 24-hour ambulatory blood pressure (BP) were checked at baseline, at 1 month, and at 3 months following RF ablation. The success rate of the renal artery approach with a standard bidirectional EP catheter was 100% (22/22 patients). The mean reduction of 24-hour ambulatory BP, and ambulatory daytime BP were respectively -8.72/-6.04 mmHg and -8.00/-6.09 mmHg at 1 month and -15.59/-9.22 mmHg and -15.27/-10.18 mmHg at 3 months (p<0.05 for systolic and diastolic BP) with unchanged medication. No severe complications were reported during the procedure and follow-up. Our initial results indicate the safety and efficacy of RDN as shown by a significant reduction of mean 24-hour ambulatory BP in comparison to baseline during short-term follow-up.
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| format | Article |
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| institution | OA Journals |
| issn | 1877-9344 1877-9352 |
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| publishDate | 2024-11-01 |
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| series | Italian Journal of Medicine |
| spelling | doaj-art-d741018e14a54fae9ea96bf90bb690eb2025-08-20T02:06:58ZengPAGEPress PublicationsItalian Journal of Medicine1877-93441877-93522024-11-0118410.4081/itjm.2024.1816Safety and efficacy of renal denervation utilizing standard bidirectional EP catheter: preliminary Vietnamese findingsTran Ba Hieu0Nguyen Ngoc Quang1Pham Manh Hung2Viet Nam National Heart Institue, Bach Mai Hospital, Ha Noi; Department of Cardiology, Ha Noi Medical UniversityViet Nam National Heart Institue, Bach Mai Hospital, Ha Noi; Department of Cardiology, Ha Noi Medical UniversityViet Nam National Heart Institue, Bach Mai Hospital, Ha Noi; Department of Cardiology, Ha Noi Medical University Renal denervation (RDN) is a safe and effective treatment for hypertensive patients. However, data on its use with standard electrophysiology catheters, particularly from low- and middle-income countries, are limited. This study aimed to evaluate the acute safety and short-term efficacy of RDN in hypertensive patients using standard EP catheters from Vietnam. A prospective study was conducted from May 2023 to May 2024 at the Viet Nam National Heart Institute, Vietnam. A total of 22 patients (mean age 52.87±19.86 years, 12 male) with resistant hypertension underwent RDN by utilizing a standard bidirectional steerable radiofrequency (RF) ablation catheter with a 7 Fr diameter (Abbott, Chicago, IL, USA). Low-power RF applications have been applied along the length of both renal arteries. Renal ultrasound, blood tests, and 24-hour ambulatory blood pressure (BP) were checked at baseline, at 1 month, and at 3 months following RF ablation. The success rate of the renal artery approach with a standard bidirectional EP catheter was 100% (22/22 patients). The mean reduction of 24-hour ambulatory BP, and ambulatory daytime BP were respectively -8.72/-6.04 mmHg and -8.00/-6.09 mmHg at 1 month and -15.59/-9.22 mmHg and -15.27/-10.18 mmHg at 3 months (p<0.05 for systolic and diastolic BP) with unchanged medication. No severe complications were reported during the procedure and follow-up. Our initial results indicate the safety and efficacy of RDN as shown by a significant reduction of mean 24-hour ambulatory BP in comparison to baseline during short-term follow-up. https://www.italjmed.org/ijm/article/view/1816Renal denervationhypertensionstandard EP catheter |
| spellingShingle | Tran Ba Hieu Nguyen Ngoc Quang Pham Manh Hung Safety and efficacy of renal denervation utilizing standard bidirectional EP catheter: preliminary Vietnamese findings Italian Journal of Medicine Renal denervation hypertension standard EP catheter |
| title | Safety and efficacy of renal denervation utilizing standard bidirectional EP catheter: preliminary Vietnamese findings |
| title_full | Safety and efficacy of renal denervation utilizing standard bidirectional EP catheter: preliminary Vietnamese findings |
| title_fullStr | Safety and efficacy of renal denervation utilizing standard bidirectional EP catheter: preliminary Vietnamese findings |
| title_full_unstemmed | Safety and efficacy of renal denervation utilizing standard bidirectional EP catheter: preliminary Vietnamese findings |
| title_short | Safety and efficacy of renal denervation utilizing standard bidirectional EP catheter: preliminary Vietnamese findings |
| title_sort | safety and efficacy of renal denervation utilizing standard bidirectional ep catheter preliminary vietnamese findings |
| topic | Renal denervation hypertension standard EP catheter |
| url | https://www.italjmed.org/ijm/article/view/1816 |
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