Association Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort Consortium
Background: Studies on the association between multimorbidity and mortality in large populations have mainly been conducted in European and North American populations. This study aimed to identify the association between cardiometabolic multimorbidity and all-cause and cardiovascular disease (CVD) m...
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Japan Epidemiological Association
2025-07-01
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| Series: | Journal of Epidemiology |
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| Online Access: | https://www.jstage.jst.go.jp/article/jea/35/7/35_JE20240362/_pdf |
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| author | Sangjun Lee Choonghyun Ahn Sarah Krull Abe Md Shafiur Rahman Md Rashedul Islam Eiko Saito Seokyung An Norie Sawada Xiao-Ou Shu Woon-Puay Koh Hui Cai Atsushi Hozawa Seiki Kanemura Chisato Nagata San-Lin You Daehee Kang Rieko Kanehara Yu-Tang Gao Jian-Min Yuan Wanqing Wen Yumi Sugawara Keiko Wada Chien-Jen Chen Keun-Young Yoo Habibul Ahsan Kee Seng Chia Aesun Shin Jeongseon Kim Jung Eun Lee Keitaro Matsuo Nathaniel Rothman You-Lin Qiao Wei Zheng Paolo Boffetta Manami Inoue Sue K. Park |
| author_facet | Sangjun Lee Choonghyun Ahn Sarah Krull Abe Md Shafiur Rahman Md Rashedul Islam Eiko Saito Seokyung An Norie Sawada Xiao-Ou Shu Woon-Puay Koh Hui Cai Atsushi Hozawa Seiki Kanemura Chisato Nagata San-Lin You Daehee Kang Rieko Kanehara Yu-Tang Gao Jian-Min Yuan Wanqing Wen Yumi Sugawara Keiko Wada Chien-Jen Chen Keun-Young Yoo Habibul Ahsan Kee Seng Chia Aesun Shin Jeongseon Kim Jung Eun Lee Keitaro Matsuo Nathaniel Rothman You-Lin Qiao Wei Zheng Paolo Boffetta Manami Inoue Sue K. Park |
| author_sort | Sangjun Lee |
| collection | DOAJ |
| description | Background: Studies on the association between multimorbidity and mortality in large populations have mainly been conducted in European and North American populations. This study aimed to identify the association between cardiometabolic multimorbidity and all-cause and cardiovascular disease (CVD) mortality in the Asia Cohort Consortium. Methods: In this prospective cohort study, pooled analysis was performed to evaluate the association between cardiometabolic diseases (hypertension, diabetes, ischemic heart disease, and stroke), multimorbidity, and all-cause and CVD mortality, including premature mortality, among participants from 11 Asian cohort studies. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox hazard regression. Results: A total of 483,532 participants were followed for a median of 14.3 years. Compared with participants without any disease, those with stroke and diabetes had higher age- and sex-adjusted HRs for all-cause mortality (HR 3.9; 95% CI, 3.28–4.56). Moreover, the age- and sex-adjusted HRs for CVD mortality were highest in participants with stroke, ischemic heart disease, and diabetes (HR 10.6; 95% CI, 6.16–18.25). These patterns remained consistent after additional adjustments for smoking status and body mass index. The risk of premature mortality followed similar trends but was more pronounced. Conclusion: These findings highlight the differential impacts of individual cardiometabolic diseases and their combinations on mortality risks. Stroke and diabetes were associated with the highest risks for all-cause and cardiovascular mortality, underscoring the need for targeted prevention and personalized management strategies tailored to these high-risk conditions in Asian populations. |
| format | Article |
| id | doaj-art-d73aefa6c76d4f1886e6b4938c242530 |
| institution | DOAJ |
| issn | 0917-5040 1349-9092 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Japan Epidemiological Association |
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| series | Journal of Epidemiology |
| spelling | doaj-art-d73aefa6c76d4f1886e6b4938c2425302025-08-20T03:15:19ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922025-07-0135732132910.2188/jea.JE20240362Association Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort ConsortiumSangjun Lee0Choonghyun Ahn1Sarah Krull Abe2Md Shafiur Rahman3Md Rashedul Islam4Eiko Saito5Seokyung An6Norie Sawada7Xiao-Ou Shu8Woon-Puay Koh9Hui Cai10Atsushi Hozawa11Seiki Kanemura12Chisato Nagata13San-Lin You14Daehee Kang15Rieko Kanehara16Yu-Tang Gao17Jian-Min Yuan18Wanqing Wen19Yumi Sugawara20Keiko Wada21Chien-Jen Chen22Keun-Young Yoo23Habibul Ahsan24Kee Seng Chia25Aesun Shin26Jeongseon Kim27Jung Eun Lee28Keitaro Matsuo29Nathaniel Rothman30You-Lin Qiao31Wei Zheng32Paolo Boffetta33Manami Inoue34Sue K. Park35Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, KoreaDepartment of Orthopaedic Surgery, National Hospital Organization Sagamihara Hospital, Kanagawa, JapanDivision of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, JapanDivision of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, JapanDivision of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, JapanSustainable Society Design Center, Graduate School of Frontier Science, The University of Tokyo, Tokyo, JapanDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, KoreaDivision of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, JapanDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USAHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USATohoku University Graduate School of Medicine, Miyagi Prefecture, Miyagi, JapanTohoku University Graduate School of Medicine, Miyagi Prefecture, Miyagi, JapanDepartment of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, JapanSchool of Medicine & Big Data Research Center, Fu Jen Catholic University, Taipei, TaiwanDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, KoreaDivision of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, JapanDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, ChinaCancer Epidemiology and Prevention Program, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Pittsburgh, PA, USADivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USATohoku University Graduate School of Medicine, Miyagi Prefecture, Miyagi, JapanDepartment of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, JapanGenomics Research Center, Academia Sinica, Taipei, TaiwanDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, KoreaDepartment of Public Health Sciences, University of Chicago, IL, USASaw Swee Hock School of Public Health, National University of Singapore, SingaporeDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, KoreaGraduate School of Cancer Science and Policy, National Cancer Center, Goyang, KoreaDepartment of Food and Nutrition, Seoul National University, Seoul, KoreaDivision Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, JapanDivision of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD, USASchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USAStony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USADivision of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, JapanDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, KoreaBackground: Studies on the association between multimorbidity and mortality in large populations have mainly been conducted in European and North American populations. This study aimed to identify the association between cardiometabolic multimorbidity and all-cause and cardiovascular disease (CVD) mortality in the Asia Cohort Consortium. Methods: In this prospective cohort study, pooled analysis was performed to evaluate the association between cardiometabolic diseases (hypertension, diabetes, ischemic heart disease, and stroke), multimorbidity, and all-cause and CVD mortality, including premature mortality, among participants from 11 Asian cohort studies. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox hazard regression. Results: A total of 483,532 participants were followed for a median of 14.3 years. Compared with participants without any disease, those with stroke and diabetes had higher age- and sex-adjusted HRs for all-cause mortality (HR 3.9; 95% CI, 3.28–4.56). Moreover, the age- and sex-adjusted HRs for CVD mortality were highest in participants with stroke, ischemic heart disease, and diabetes (HR 10.6; 95% CI, 6.16–18.25). These patterns remained consistent after additional adjustments for smoking status and body mass index. The risk of premature mortality followed similar trends but was more pronounced. Conclusion: These findings highlight the differential impacts of individual cardiometabolic diseases and their combinations on mortality risks. Stroke and diabetes were associated with the highest risks for all-cause and cardiovascular mortality, underscoring the need for targeted prevention and personalized management strategies tailored to these high-risk conditions in Asian populations.https://www.jstage.jst.go.jp/article/jea/35/7/35_JE20240362/_pdfcardiometabolic multimorbidityprospective cohort studyasian populations |
| spellingShingle | Sangjun Lee Choonghyun Ahn Sarah Krull Abe Md Shafiur Rahman Md Rashedul Islam Eiko Saito Seokyung An Norie Sawada Xiao-Ou Shu Woon-Puay Koh Hui Cai Atsushi Hozawa Seiki Kanemura Chisato Nagata San-Lin You Daehee Kang Rieko Kanehara Yu-Tang Gao Jian-Min Yuan Wanqing Wen Yumi Sugawara Keiko Wada Chien-Jen Chen Keun-Young Yoo Habibul Ahsan Kee Seng Chia Aesun Shin Jeongseon Kim Jung Eun Lee Keitaro Matsuo Nathaniel Rothman You-Lin Qiao Wei Zheng Paolo Boffetta Manami Inoue Sue K. Park Association Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort Consortium Journal of Epidemiology cardiometabolic multimorbidity prospective cohort study asian populations |
| title | Association Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort Consortium |
| title_full | Association Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort Consortium |
| title_fullStr | Association Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort Consortium |
| title_full_unstemmed | Association Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort Consortium |
| title_short | Association Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort Consortium |
| title_sort | association between cardiometabolic multimorbidity and 15 year mortality in the asia cohort consortium |
| topic | cardiometabolic multimorbidity prospective cohort study asian populations |
| url | https://www.jstage.jst.go.jp/article/jea/35/7/35_JE20240362/_pdf |
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