Next-Generation Biomaterials for Wound Healing: Development and Evaluation of Collagen Scaffolds Functionalized with a Heparan Sulfate Mimic and Fibroblast Growth Factor 2

Next-Generation Biomaterials for Wound Healing: Development and Evaluation of Collagen Scaffolds Functionalized with a Heparan Sulfate Mimic and Fibroblast Growth Factor 2

Fibrosis after full-thickness wound healing—especially after severe burn wounds—remains a clinically relevant problem. Biomaterials that mimic the lost dermal extracellular matrix have shown promise but cannot completely prevent scar formation. We present a novel approach where porous type I collage...

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Bibliographic Details
Main Authors: Merel Gansevoort, Sabine Wentholt, Gaia Li Vecchi, Marjolein de Vries, Elly M. M. Versteeg, Bouke K. H. L. Boekema, Agnes Choppin, Denis Barritault, Franck Chiappini, Toin H. van Kuppevelt, Willeke F. Daamen
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Journal of Functional Biomaterials
Subjects:
biomaterial
wound healing
skin regeneration
collagen
heparin/heparan sulfate
fibrosis
Online Access:https://www.mdpi.com/2079-4983/16/2/51
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