Associations between vitamins intake and risk of cancer in United States adults: 2003 to 2016 national health and nutrition examination survey
IntroductionNational Health and Nutrition Examination Survey (NHANES) is a cross-sectional survey that gathered information about people’s health and nutrition. The aim of this study is to investigate potential associations between vitamin intake and cancer risk using this database.MethodsThe NHANES...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-04-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1561251/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850273664089456640 |
|---|---|
| author | Youfei Wen Youfei Wen Xiuzhen Yang Yan Huang |
| author_facet | Youfei Wen Youfei Wen Xiuzhen Yang Yan Huang |
| author_sort | Youfei Wen |
| collection | DOAJ |
| description | IntroductionNational Health and Nutrition Examination Survey (NHANES) is a cross-sectional survey that gathered information about people’s health and nutrition. The aim of this study is to investigate potential associations between vitamin intake and cancer risk using this database.MethodsThe NHANES data set encompassed a wide range of variables, including vitamins, cancer, and others. Logistic regression models, restricted cubic splines (RCS) and subgroup analysis were used to test the potential link between vitamin consumption and cancer risk.ResultsIn total, 29, 138 individuals were included in this study, while 2,924 of them had a diagnosis of cancer. The odds of developing cancer were reduced for persons consuming the highest quartile of dietary niacin compared to those consuming the lowest quartile [odds ratio (OR) = 0.78, 95% confidence range = 0.65, 0.95, p = 0.015]. However, after adjusting for all confounding factors, as the intake of vitamin A gradually increased, the risk of tumor occurrence correspondingly increased (OR = 1.38, 95% CI 1.13, 1.69, p = 0.002). Subgroup analysis and RCS models showed similar results. Only when the intake of folic acid is 267–367 mcg, folic acid is positively correlated with the risk of tumors. Vitamins E, B1, B2, B6, B12, C, K, alpha-carotene and beta-carotene were not associated with the risk of tumor development.ConclusionVitamin A intake is positively correlated with the occurrence of tumors, while niacin intake is negatively correlated with the incidence of tumors. Further longitudinal studies are needed to verify these findings. |
| format | Article |
| id | doaj-art-d736fd53d1944f9089ac7973e892a384 |
| institution | OA Journals |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-d736fd53d1944f9089ac7973e892a3842025-08-20T01:51:24ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-04-011210.3389/fnut.2025.15612511561251Associations between vitamins intake and risk of cancer in United States adults: 2003 to 2016 national health and nutrition examination surveyYoufei Wen0Youfei Wen1Xiuzhen Yang2Yan Huang3Department of Gastroenterology, Guizhou Hospital of the First Affiliated Hospital of Sun Yat-sen University, Guiyang, ChinaDepartment of Gastroenterology, Gui’an Hospital of the Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaIntroductionNational Health and Nutrition Examination Survey (NHANES) is a cross-sectional survey that gathered information about people’s health and nutrition. The aim of this study is to investigate potential associations between vitamin intake and cancer risk using this database.MethodsThe NHANES data set encompassed a wide range of variables, including vitamins, cancer, and others. Logistic regression models, restricted cubic splines (RCS) and subgroup analysis were used to test the potential link between vitamin consumption and cancer risk.ResultsIn total, 29, 138 individuals were included in this study, while 2,924 of them had a diagnosis of cancer. The odds of developing cancer were reduced for persons consuming the highest quartile of dietary niacin compared to those consuming the lowest quartile [odds ratio (OR) = 0.78, 95% confidence range = 0.65, 0.95, p = 0.015]. However, after adjusting for all confounding factors, as the intake of vitamin A gradually increased, the risk of tumor occurrence correspondingly increased (OR = 1.38, 95% CI 1.13, 1.69, p = 0.002). Subgroup analysis and RCS models showed similar results. Only when the intake of folic acid is 267–367 mcg, folic acid is positively correlated with the risk of tumors. Vitamins E, B1, B2, B6, B12, C, K, alpha-carotene and beta-carotene were not associated with the risk of tumor development.ConclusionVitamin A intake is positively correlated with the occurrence of tumors, while niacin intake is negatively correlated with the incidence of tumors. Further longitudinal studies are needed to verify these findings.https://www.frontiersin.org/articles/10.3389/fnut.2025.1561251/fullvitaminscancerniacinvitamin ANHANES |
| spellingShingle | Youfei Wen Youfei Wen Xiuzhen Yang Yan Huang Associations between vitamins intake and risk of cancer in United States adults: 2003 to 2016 national health and nutrition examination survey Frontiers in Nutrition vitamins cancer niacin vitamin A NHANES |
| title | Associations between vitamins intake and risk of cancer in United States adults: 2003 to 2016 national health and nutrition examination survey |
| title_full | Associations between vitamins intake and risk of cancer in United States adults: 2003 to 2016 national health and nutrition examination survey |
| title_fullStr | Associations between vitamins intake and risk of cancer in United States adults: 2003 to 2016 national health and nutrition examination survey |
| title_full_unstemmed | Associations between vitamins intake and risk of cancer in United States adults: 2003 to 2016 national health and nutrition examination survey |
| title_short | Associations between vitamins intake and risk of cancer in United States adults: 2003 to 2016 national health and nutrition examination survey |
| title_sort | associations between vitamins intake and risk of cancer in united states adults 2003 to 2016 national health and nutrition examination survey |
| topic | vitamins cancer niacin vitamin A NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1561251/full |
| work_keys_str_mv | AT youfeiwen associationsbetweenvitaminsintakeandriskofcancerinunitedstatesadults2003to2016nationalhealthandnutritionexaminationsurvey AT youfeiwen associationsbetweenvitaminsintakeandriskofcancerinunitedstatesadults2003to2016nationalhealthandnutritionexaminationsurvey AT xiuzhenyang associationsbetweenvitaminsintakeandriskofcancerinunitedstatesadults2003to2016nationalhealthandnutritionexaminationsurvey AT yanhuang associationsbetweenvitaminsintakeandriskofcancerinunitedstatesadults2003to2016nationalhealthandnutritionexaminationsurvey |