Identification of potential key targets and mechanisms underlying cleft palate induced by tobacco smoke exposure through multi-omics integrated Mendelian randomization analysis

Identification of potential key targets and mechanisms underlying cleft palate induced by tobacco smoke exposure through multi-omics integrated Mendelian randomization analysis

Tobacco smoke (TS), a major indoor air pollutant, poses a significant health threat, notably increasing the incidence of congenital malformations, particularly cleft palate (CP). Although the mechanisms underlying TS-induced CP remain incompletely understood, this study provides novel insights by in...

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Bibliographic Details
Main Authors: Yuxin Lin, Xiaoping Zhong, Zhengyuan Chi, Hui Li, Rui Han, Hao Li, Shukai Zheng, Shijie Tang, Jiasheng Chen
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Tobacco smoke exposure
Cleft palate
Multi-omics integrated Mendelian Randomization analysis
3-Phospho-D-glycerate (3-PG)
TMTC1
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325007304
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