New insights into the roles of lactylation in cancer
Lactylation, a novel discovered posttranslational modification, is a vital component of lactate function and is prevalent in a wide range of cells, interacting with both histone and non-histone proteins. Recent studies have confirmed that lactylation as a new contributor to epigenetic landscape is i...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-10-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1412672/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850215115828232192 |
|---|---|
| author | Yajun Zhu Yajun Zhu Wenhui Liu Wenhui Liu Zhiying Luo Zhiying Luo Feiyan Xiao Bao Sun Bao Sun |
| author_facet | Yajun Zhu Yajun Zhu Wenhui Liu Wenhui Liu Zhiying Luo Zhiying Luo Feiyan Xiao Bao Sun Bao Sun |
| author_sort | Yajun Zhu |
| collection | DOAJ |
| description | Lactylation, a novel discovered posttranslational modification, is a vital component of lactate function and is prevalent in a wide range of cells, interacting with both histone and non-histone proteins. Recent studies have confirmed that lactylation as a new contributor to epigenetic landscape is involved in multiple pathological processes. Accumulating evidence reveals that lactylation exists in different pathophysiological states and leads to inflammation and cancer; however, few mechanisms of lactylation have been elaborated. This review summarizes the biological processes and pathophysiological roles of lactylation in cancer, as well as discusses the relevant mechanisms and potential therapeutic targets, aiming to provide new insights for targeted cancer therapy. |
| format | Article |
| id | doaj-art-d735e5c5d7c74c08871a4b90d8e35cfa |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-d735e5c5d7c74c08871a4b90d8e35cfa2025-08-20T02:08:42ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-10-011510.3389/fphar.2024.14126721412672New insights into the roles of lactylation in cancerYajun Zhu0Yajun Zhu1Wenhui Liu2Wenhui Liu3Zhiying Luo4Zhiying Luo5Feiyan Xiao6Bao Sun7Bao Sun8Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Clinical Pharmacy, Central South University, Changsha, ChinaDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Clinical Pharmacy, Central South University, Changsha, ChinaDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Clinical Pharmacy, Central South University, Changsha, ChinaCenter for Clinical Trial and Research, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Clinical Pharmacy, Central South University, Changsha, ChinaLactylation, a novel discovered posttranslational modification, is a vital component of lactate function and is prevalent in a wide range of cells, interacting with both histone and non-histone proteins. Recent studies have confirmed that lactylation as a new contributor to epigenetic landscape is involved in multiple pathological processes. Accumulating evidence reveals that lactylation exists in different pathophysiological states and leads to inflammation and cancer; however, few mechanisms of lactylation have been elaborated. This review summarizes the biological processes and pathophysiological roles of lactylation in cancer, as well as discusses the relevant mechanisms and potential therapeutic targets, aiming to provide new insights for targeted cancer therapy.https://www.frontiersin.org/articles/10.3389/fphar.2024.1412672/fulllactylationlactatehistone and non-histone proteinscancertherapeutic targets |
| spellingShingle | Yajun Zhu Yajun Zhu Wenhui Liu Wenhui Liu Zhiying Luo Zhiying Luo Feiyan Xiao Bao Sun Bao Sun New insights into the roles of lactylation in cancer Frontiers in Pharmacology lactylation lactate histone and non-histone proteins cancer therapeutic targets |
| title | New insights into the roles of lactylation in cancer |
| title_full | New insights into the roles of lactylation in cancer |
| title_fullStr | New insights into the roles of lactylation in cancer |
| title_full_unstemmed | New insights into the roles of lactylation in cancer |
| title_short | New insights into the roles of lactylation in cancer |
| title_sort | new insights into the roles of lactylation in cancer |
| topic | lactylation lactate histone and non-histone proteins cancer therapeutic targets |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1412672/full |
| work_keys_str_mv | AT yajunzhu newinsightsintotherolesoflactylationincancer AT yajunzhu newinsightsintotherolesoflactylationincancer AT wenhuiliu newinsightsintotherolesoflactylationincancer AT wenhuiliu newinsightsintotherolesoflactylationincancer AT zhiyingluo newinsightsintotherolesoflactylationincancer AT zhiyingluo newinsightsintotherolesoflactylationincancer AT feiyanxiao newinsightsintotherolesoflactylationincancer AT baosun newinsightsintotherolesoflactylationincancer AT baosun newinsightsintotherolesoflactylationincancer |