Sotorasib resistance in KRAS G12C-mutant invasive mucinous adenocarcinoma with implications for VEGF-A

Sotorasib resistance in KRAS G12C-mutant invasive mucinous adenocarcinoma with implications for VEGF-A

Abstract Invasive mucinous adenocarcinoma (IMA) is a rare subtype of lung adenocarcinoma with a poor prognosis. Compared to non-small cell lung cancer, IMA more frequently harbors KRAS mutations in the order p.G12V, p.G12D, and p.G12C. This report describes a patient with a KRAS p.G12C-mutant IMA tr...

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Main Authors: Hiraku Yanada, Ryohei Yoshida, Ryotaro Kida, Kiichi Nitanai, Maya Ikeda, Kazunori Nagasue, Taeka Naraoka, Masashi Ueda, Takashi Watanabe, Ryota Shigaki, Yasuhiro Umekage, Yoshinori Minami, Toshihiro Nagato, Manami Hayashi, Sayaka Yuzawa, Mishie Tanino, Takaaki Sasaki
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00953-2
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