Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury
In this study, we investigated the gastroprotective effect of an isopropanol extract from the aerial parts of Artemisia princeps (IPAP) and developed a gastroretentive floating tablet of IPAP (IPAP-FR) for maximized local gastroprotective effects. Pre-treatment with IPAP ameliorated the gastric muco...
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| Format: | Article |
| Language: | English |
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2017-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2017-0037 |
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| author | Kim Joo-Il Park Sang-Wook Lim Jhong-Jae Sohn Se-Il Shin Ji-Su Park Sang Cheol Jang Young Pyo Chung Eun Kyoung Lee Hong-Woo Lee Kyung-Tae |
| author_facet | Kim Joo-Il Park Sang-Wook Lim Jhong-Jae Sohn Se-Il Shin Ji-Su Park Sang Cheol Jang Young Pyo Chung Eun Kyoung Lee Hong-Woo Lee Kyung-Tae |
| author_sort | Kim Joo-Il |
| collection | DOAJ |
| description | In this study, we investigated the gastroprotective effect of an isopropanol extract from the aerial parts of Artemisia princeps (IPAP) and developed a gastroretentive floating tablet of IPAP (IPAP-FR) for maximized local gastroprotective effects. Pre-treatment with IPAP ameliorated the gastric mucosal hemorrhagic lesions in ethanol/HCl- or indomethacin- treated rats. IPAP decreased mucosal hemorrhage of gastric ulcers induced by ethanol or indomethacin plus pyloric ligation in rats. The optimized floating tablet, IPAP-FR, floated on medium surface with more sustained eupatilin release compared to the non-floating control tablet. X-ray photographs in beagle dogs showed that IPAPFR was retained for > 2 h in the stomach. In the ethanol-induced gastric ulcer rat model, the gastric hemorrhagic lesion was improved more substantially with IPAP-FR compared to the non-floating control tablet. Based on these data, our data suggest that IPAP-FR has an improved therapeutic potential for the treatment of gastric ulcer. |
| format | Article |
| id | doaj-art-d728596f59f848bb95dfb701c4983cc0 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2017-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-d728596f59f848bb95dfb701c4983cc02025-02-02T11:50:20ZengSciendoActa Pharmaceutica1846-95582017-12-0167447949410.1515/acph-2017-0037acph-2017-0037Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injuryKim Joo-Il0Park Sang-Wook1Lim Jhong-Jae2Sohn Se-Il3Shin Ji-Su4Park Sang Cheol5Jang Young Pyo6Chung Eun Kyoung7Lee Hong-Woo8Lee Kyung-Tae9Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro Dongdaemun-gu, Seoul, 02447, Korea Republic ofCentral Research Institute, Daewon Pharmaceutical Company, 520 Cheonho-daero, Gwangjin-gu, Seoul Republic of KoreaCentral Research Institute, Daewon Pharmaceutical Company, 520 Cheonho-daero, Gwangjin-gu, Seoul Republic of KoreaCentral Research Institute, Daewon Pharmaceutical Company, 520 Cheonho-daero, Gwangjin-gu, Seoul Republic of KoreaDepartment of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro Dongdaemun-gu, Seoul, 02447, Korea Republic ofDepartment of Life and Nanopharmaceutical Science College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Korea Republic ofDepartment of Life and Nanopharmaceutical Science College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Korea 5 Department of Oriental Pharmaceutical Sciences College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Korea Republic ofDepartment of Pharmacy, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu Seoul, 02447, Korea Republic ofCentral Research Institute, Daewon Pharmaceutical Company, 520 Cheonho-daero, Gwangjin-gu, Seoul Republic of KoreaDepartment of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro Dongdaemun-gu, Seoul, 02447, Korea Republic ofIn this study, we investigated the gastroprotective effect of an isopropanol extract from the aerial parts of Artemisia princeps (IPAP) and developed a gastroretentive floating tablet of IPAP (IPAP-FR) for maximized local gastroprotective effects. Pre-treatment with IPAP ameliorated the gastric mucosal hemorrhagic lesions in ethanol/HCl- or indomethacin- treated rats. IPAP decreased mucosal hemorrhage of gastric ulcers induced by ethanol or indomethacin plus pyloric ligation in rats. The optimized floating tablet, IPAP-FR, floated on medium surface with more sustained eupatilin release compared to the non-floating control tablet. X-ray photographs in beagle dogs showed that IPAPFR was retained for > 2 h in the stomach. In the ethanol-induced gastric ulcer rat model, the gastric hemorrhagic lesion was improved more substantially with IPAP-FR compared to the non-floating control tablet. Based on these data, our data suggest that IPAP-FR has an improved therapeutic potential for the treatment of gastric ulcer.https://doi.org/10.1515/acph-2017-0037artemisia princeps pamp.antiulcereupatilinfloating drug delivery systemxray photographs |
| spellingShingle | Kim Joo-Il Park Sang-Wook Lim Jhong-Jae Sohn Se-Il Shin Ji-Su Park Sang Cheol Jang Young Pyo Chung Eun Kyoung Lee Hong-Woo Lee Kyung-Tae Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury Acta Pharmaceutica artemisia princeps pamp. antiulcer eupatilin floating drug delivery system xray photographs |
| title | Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury |
| title_full | Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury |
| title_fullStr | Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury |
| title_full_unstemmed | Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury |
| title_short | Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury |
| title_sort | gastroprotective effects of the isopropanol extract of artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury |
| topic | artemisia princeps pamp. antiulcer eupatilin floating drug delivery system xray photographs |
| url | https://doi.org/10.1515/acph-2017-0037 |
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