Hidradenitis suppurativa and daily lifestyle
Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory skin disorder that significantly impairs quality of life. While its pathogenesis involves genetic, immunologic, and environmental components, emerging evidence highlights the substantial impact of modifiable lifestyle factors on dise...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1627638/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850120014349205504 |
|---|---|
| author | Natsuko Saito-Sasaki Yu Sawada |
| author_facet | Natsuko Saito-Sasaki Yu Sawada |
| author_sort | Natsuko Saito-Sasaki |
| collection | DOAJ |
| description | Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory skin disorder that significantly impairs quality of life. While its pathogenesis involves genetic, immunologic, and environmental components, emerging evidence highlights the substantial impact of modifiable lifestyle factors on disease onset and progression. This review summarizes the current understanding of how lifestyle-related elements interact with the inflammatory milieu in HS. Beneficial factors, such as short-chain fatty acids (SCFAs), omega-3 fatty acids, and vitamin D, play a protective role by suppressing proinflammatory cytokines, enhancing antimicrobial responses, and promoting the growth of beneficial gut microbiota. Diets rich in vegetables, fruits, chicken, and fish are supportive in maintaining immune balance. Conversely, detrimental factors, including smoking, alcohol consumption, obesity, and sleep disorders, are associated with heightened inflammatory responses, increased disease severity, and higher recurrence rates. Understanding these lifestyle-related influences provides a foundation for non-pharmacologic, adjunctive interventions aimed at mitigating disease burden. Comprehensive management of HS should therefore include lifestyle modification as a key component to improve patient outcomes. |
| format | Article |
| id | doaj-art-d726a170141c4f0cb932306aaa545f95 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-d726a170141c4f0cb932306aaa545f952025-08-20T02:35:30ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.16276381627638Hidradenitis suppurativa and daily lifestyleNatsuko Saito-SasakiYu SawadaHidradenitis suppurativa (HS) is a chronic, relapsing inflammatory skin disorder that significantly impairs quality of life. While its pathogenesis involves genetic, immunologic, and environmental components, emerging evidence highlights the substantial impact of modifiable lifestyle factors on disease onset and progression. This review summarizes the current understanding of how lifestyle-related elements interact with the inflammatory milieu in HS. Beneficial factors, such as short-chain fatty acids (SCFAs), omega-3 fatty acids, and vitamin D, play a protective role by suppressing proinflammatory cytokines, enhancing antimicrobial responses, and promoting the growth of beneficial gut microbiota. Diets rich in vegetables, fruits, chicken, and fish are supportive in maintaining immune balance. Conversely, detrimental factors, including smoking, alcohol consumption, obesity, and sleep disorders, are associated with heightened inflammatory responses, increased disease severity, and higher recurrence rates. Understanding these lifestyle-related influences provides a foundation for non-pharmacologic, adjunctive interventions aimed at mitigating disease burden. Comprehensive management of HS should therefore include lifestyle modification as a key component to improve patient outcomes.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1627638/fullhidradenitis suppurativalifestyle factorssmokingdietphysical activity |
| spellingShingle | Natsuko Saito-Sasaki Yu Sawada Hidradenitis suppurativa and daily lifestyle Frontiers in Immunology hidradenitis suppurativa lifestyle factors smoking diet physical activity |
| title | Hidradenitis suppurativa and daily lifestyle |
| title_full | Hidradenitis suppurativa and daily lifestyle |
| title_fullStr | Hidradenitis suppurativa and daily lifestyle |
| title_full_unstemmed | Hidradenitis suppurativa and daily lifestyle |
| title_short | Hidradenitis suppurativa and daily lifestyle |
| title_sort | hidradenitis suppurativa and daily lifestyle |
| topic | hidradenitis suppurativa lifestyle factors smoking diet physical activity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1627638/full |
| work_keys_str_mv | AT natsukosaitosasaki hidradenitissuppurativaanddailylifestyle AT yusawada hidradenitissuppurativaanddailylifestyle |