Potentiating T cell tumor targeting using a combination of TCR with a Siglec-7 based CSR

Potentiating T cell tumor targeting using a combination of TCR with a Siglec-7 based CSR

IntroductionTumors may utilize different strategies to escape T cell immunosurveillance. Besides the overexpression of checkpoint ligands (such as PDL1) or the secretion of immunosuppressive agents, several studies have shown that cancer aberrant sialylation can, through interaction with selected re...

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Bibliographic Details
Main Authors: Shiran Didi-Zurinam, Erel Katzman, Cyrille J. Cohen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
T-cells
immunotherapy
co-stimulatory chimeric switch receptor (CSR)
sialic acids
Siglec-7
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1536868/full
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