Lycopene alleviates 5-fluorouracil-induced nephrotoxicity by modulating PPAR-γ, Nrf2/HO-1, and NF-κB/TNF-α/IL-6 signals

Lycopene alleviates 5-fluorouracil-induced nephrotoxicity by modulating PPAR-γ, Nrf2/HO-1, and NF-κB/TNF-α/IL-6 signals

5-Fluorouracil (5-FU) is one of the most used anticancer drugs. However, its nephrotoxicity-associated drawback is of clinical concern. Lycopene (LYC) is a red carotenoid with remarkable anti-inflammatory and anti-oxidative properties. In this study, rats were divided randomly into five groups: cont...

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Bibliographic Details
Main Authors: Ghadeer M. Albadrani, Ahmed E. Altyar, Osama A. Kensara, Mohie A.M Haridy, Amany A. Sayed, Zuhair M. Mohammedsaleh, Muath Q. Al-Ghadi, Rasha Mohammed Saleem, Mohamed M. Abdel-Daim
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Renal Failure
Subjects:
Lycopene
5-fluorouracil
nephrotoxicity
PPAR-γ
Nrf2/HO-1
NF-κB
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2024.2423843
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