Use of Maribavir for Multidrug-Resistant Cytomegalovirus in an Immunocompromised Host With HIV and Common Variable Immunodeficiency
We present a case of multidrug-resistant Cytomegalovirus (CMV) and the use of maribavir, a novel oral treatment of resistant CMV, in a nontransplant immunocompromised host. Our patient initially was diagnosed with CMV pharyngitis on biopsy. Although his initial CMV pharyngitis resolved, the CMV isol...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2024-06-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2023.1153 |
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| author | Diana Zarowin Jared Coe Maxwell Bressman Paul Riska Philip Yune Ghaleb Halaseh Matthew J. Akiyama |
| author_facet | Diana Zarowin Jared Coe Maxwell Bressman Paul Riska Philip Yune Ghaleb Halaseh Matthew J. Akiyama |
| author_sort | Diana Zarowin |
| collection | DOAJ |
| description | We present a case of multidrug-resistant Cytomegalovirus (CMV) and the use of maribavir, a novel oral treatment of resistant CMV, in a nontransplant immunocompromised host. Our patient initially was diagnosed with CMV pharyngitis on biopsy. Although his initial CMV pharyngitis resolved, the CMV isolated from blood became resistant to ganciclovir and cidofovir and eventually required treatment with foscarnet. Our patient was given a trial of maribavir. After 6 weeks, the patient's viremia resolved and remained undetectable for 6 months after treatment initiation with maribavir. This case demonstrates the feasibility of using maribavir for resistant CMV in a nontransplant, immunocompromised patient. |
| format | Article |
| id | doaj-art-d71c72c48de3425f80525e18cd271f36 |
| institution | OA Journals |
| issn | 2767-7664 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-d71c72c48de3425f80525e18cd271f362025-08-20T02:11:45ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642024-06-013610.7326/aimcc.2023.1153Use of Maribavir for Multidrug-Resistant Cytomegalovirus in an Immunocompromised Host With HIV and Common Variable ImmunodeficiencyDiana Zarowin0Jared Coe1Maxwell Bressman2Paul Riska3Philip Yune4Ghaleb Halaseh5Matthew J. Akiyama61Albert Einstein College of Medicine, Bronx, New York2Department of Medicine, Division of Infectious Diseases, Montefiore Medical Center, Bronx, New York3Department of Medicine, Division of General Internal Medicine, Montefiore Medical Center, Bronx, New York2Department of Medicine, Division of Infectious Diseases, Montefiore Medical Center, Bronx, New York2Department of Medicine, Division of Infectious Diseases, Montefiore Medical Center, Bronx, New York2Department of Medicine, Division of Infectious Diseases, Montefiore Medical Center, Bronx, New York1Albert Einstein College of Medicine, Bronx, New YorkWe present a case of multidrug-resistant Cytomegalovirus (CMV) and the use of maribavir, a novel oral treatment of resistant CMV, in a nontransplant immunocompromised host. Our patient initially was diagnosed with CMV pharyngitis on biopsy. Although his initial CMV pharyngitis resolved, the CMV isolated from blood became resistant to ganciclovir and cidofovir and eventually required treatment with foscarnet. Our patient was given a trial of maribavir. After 6 weeks, the patient's viremia resolved and remained undetectable for 6 months after treatment initiation with maribavir. This case demonstrates the feasibility of using maribavir for resistant CMV in a nontransplant, immunocompromised patient.https://www.acpjournals.org/doi/10.7326/aimcc.2023.1153 |
| spellingShingle | Diana Zarowin Jared Coe Maxwell Bressman Paul Riska Philip Yune Ghaleb Halaseh Matthew J. Akiyama Use of Maribavir for Multidrug-Resistant Cytomegalovirus in an Immunocompromised Host With HIV and Common Variable Immunodeficiency Annals of Internal Medicine: Clinical Cases |
| title | Use of Maribavir for Multidrug-Resistant Cytomegalovirus in an Immunocompromised Host With HIV and Common Variable Immunodeficiency |
| title_full | Use of Maribavir for Multidrug-Resistant Cytomegalovirus in an Immunocompromised Host With HIV and Common Variable Immunodeficiency |
| title_fullStr | Use of Maribavir for Multidrug-Resistant Cytomegalovirus in an Immunocompromised Host With HIV and Common Variable Immunodeficiency |
| title_full_unstemmed | Use of Maribavir for Multidrug-Resistant Cytomegalovirus in an Immunocompromised Host With HIV and Common Variable Immunodeficiency |
| title_short | Use of Maribavir for Multidrug-Resistant Cytomegalovirus in an Immunocompromised Host With HIV and Common Variable Immunodeficiency |
| title_sort | use of maribavir for multidrug resistant cytomegalovirus in an immunocompromised host with hiv and common variable immunodeficiency |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2023.1153 |
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