Associations among air pollution, asthma and lung function: a cross-sectional study
Abstract Ambient air pollution affects the respiratory system, but evidence of its impacts on asthma and lung function is lacking. We aimed to evaluate whether ambient air pollutants are associated with asthma prevalence, asthma outcomes, and lung function in adults. A cross-sectional study of 454,9...
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Nature Portfolio
2025-04-01
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| author | Jun Cheng Zhichen Liu Dianwu Li Yiqun Zhu Jiefeng Luo Yan Zhang |
| author_facet | Jun Cheng Zhichen Liu Dianwu Li Yiqun Zhu Jiefeng Luo Yan Zhang |
| author_sort | Jun Cheng |
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| description | Abstract Ambient air pollution affects the respiratory system, but evidence of its impacts on asthma and lung function is lacking. We aimed to evaluate whether ambient air pollutants are associated with asthma prevalence, asthma outcomes, and lung function in adults. A cross-sectional study of 454,921 adults aged 37 to 73 years from the UK Biobank was performed with linear or logistic regression to assess the associations among air pollution and asthma prevalence, current wheezing, asthma hospitalizations and lung function. Each interquartile range (IQR) increase in of PM2.5 (odds ratio [OR]: 1.023, 95% confidence interval [CI]: 1.011–1.035), PM10 (OR: 1.013, 95% CI: 1.004–1.022), NO2 (OR: 1.025, 95% CI: 1.013–1.039), and NOx (OR: 1.019, 95% CI: 1.008–1.029) was significantly associated with asthma prevalence, respectively. Moreover, exposure to air pollution was related to increased odds of current wheezing and asthma-related hospitalization. Among asthmatic participants, each IQR increase in PMcoarse, PM10, NO2, and NOx was significantly associated with decreases of 5.143 ml, 7.614 ml, 13.266 ml, 9.440 ml, respectively, for the forced expiratory volume in one second and 11.744 ml, 15.637 ml, 13.041 ml, 9.063 ml, respectively, for the forced vital capacity. In a large sample size study of British adults, air pollution was related to increased odds of asthma prevalence. Among the asthmatic population, air pollution was associated with increased odds of current wheezing, hospitalization, and decreased lung function. |
| format | Article |
| id | doaj-art-d714f24159504dfc92e00df7eaeb6d1c |
| institution | DOAJ |
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| spelling | doaj-art-d714f24159504dfc92e00df7eaeb6d1c2025-08-20T03:04:50ZengNature PortfolioScientific Reports2045-23222025-04-011511910.1038/s41598-025-88807-6Associations among air pollution, asthma and lung function: a cross-sectional studyJun Cheng0Zhichen Liu1Dianwu Li2Yiqun Zhu3Jiefeng Luo4Yan Zhang5Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityDepartment of Orthopaedics, Xiangya Hospital, Central South UniversityDepartment of Respiratory Medicine, Xiangya Hospital, Central South UniversityDepartment of Respiratory Medicine, Xiangya Hospital, Central South UniversityDepartment of Gynecology and Obstetrics, Xiangya Hospital Central South UniversityDepartment of Respiratory Medicine, Xiangya Hospital, Central South UniversityAbstract Ambient air pollution affects the respiratory system, but evidence of its impacts on asthma and lung function is lacking. We aimed to evaluate whether ambient air pollutants are associated with asthma prevalence, asthma outcomes, and lung function in adults. A cross-sectional study of 454,921 adults aged 37 to 73 years from the UK Biobank was performed with linear or logistic regression to assess the associations among air pollution and asthma prevalence, current wheezing, asthma hospitalizations and lung function. Each interquartile range (IQR) increase in of PM2.5 (odds ratio [OR]: 1.023, 95% confidence interval [CI]: 1.011–1.035), PM10 (OR: 1.013, 95% CI: 1.004–1.022), NO2 (OR: 1.025, 95% CI: 1.013–1.039), and NOx (OR: 1.019, 95% CI: 1.008–1.029) was significantly associated with asthma prevalence, respectively. Moreover, exposure to air pollution was related to increased odds of current wheezing and asthma-related hospitalization. Among asthmatic participants, each IQR increase in PMcoarse, PM10, NO2, and NOx was significantly associated with decreases of 5.143 ml, 7.614 ml, 13.266 ml, 9.440 ml, respectively, for the forced expiratory volume in one second and 11.744 ml, 15.637 ml, 13.041 ml, 9.063 ml, respectively, for the forced vital capacity. In a large sample size study of British adults, air pollution was related to increased odds of asthma prevalence. Among the asthmatic population, air pollution was associated with increased odds of current wheezing, hospitalization, and decreased lung function.https://doi.org/10.1038/s41598-025-88807-6Air pollutionAsthmaLung functionsWheezingHospitalizationUK Biobank |
| spellingShingle | Jun Cheng Zhichen Liu Dianwu Li Yiqun Zhu Jiefeng Luo Yan Zhang Associations among air pollution, asthma and lung function: a cross-sectional study Scientific Reports Air pollution Asthma Lung functions Wheezing Hospitalization UK Biobank |
| title | Associations among air pollution, asthma and lung function: a cross-sectional study |
| title_full | Associations among air pollution, asthma and lung function: a cross-sectional study |
| title_fullStr | Associations among air pollution, asthma and lung function: a cross-sectional study |
| title_full_unstemmed | Associations among air pollution, asthma and lung function: a cross-sectional study |
| title_short | Associations among air pollution, asthma and lung function: a cross-sectional study |
| title_sort | associations among air pollution asthma and lung function a cross sectional study |
| topic | Air pollution Asthma Lung functions Wheezing Hospitalization UK Biobank |
| url | https://doi.org/10.1038/s41598-025-88807-6 |
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