A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy
Objective: Larynx cancer constitutes 2% of all cancers in adults with 96% of larynx malignancies being squamous cell carcinoma (SHC). Apoptosis is a cell death mechanism that is quite different from necrosis. It is also known as programmed cell death, physiological cell death, or cell suicide. Physi...
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Istanbul University Press
2022-06-01
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| Series: | The Turkish Journal of Ear Nose and Throat |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/CF52E42E98E544A9978A157AD9EE79DB |
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| author | Ahmet Mert Bilgili Tolga Ersözlü |
| author_facet | Ahmet Mert Bilgili Tolga Ersözlü |
| author_sort | Ahmet Mert Bilgili |
| collection | DOAJ |
| description | Objective: Larynx cancer constitutes 2% of all cancers in adults with 96% of larynx malignancies being squamous cell carcinoma (SHC). Apoptosis is a cell death mechanism that is quite different from necrosis. It is also known as programmed cell death, physiological cell death, or cell suicide. Physiological mediators that activate programmed cell death (apoptosis) are Fas and Fas Ligand (FasL). Materials and Methods: In a thesis study conducted by our authors in 2004, we investigated the relationship of Fas-Fas ligand-mediated apoptosis with survival in laryngeal cancer, prognostic factors (age, localization, histological grade, tumor size, lymph, blood vessel invasion), stage, and inflammatory response of the tumor. In this study, we investigated the relationship between survival and death rates after 20 years and Fas-FasL. Results: When FAS was evaluated 20 years later, a statistically significant difference was found between mortality rates depending on stage (p=0.023; p<0.05). While the survival rate is higher in stage 1 cases, the rate of death is higher in stage 3 cases. No statistically significant difference was found between mortality rates according to stages for FAS Ligand 20 years later (p>0.05). Conclusion: In conclusion, we found that the Fas/Fas-L system was not associated with clinical parameters in laryngeal cancers in our short-term follow-up. However, when we repeated our follow-up 20 years later, we found that Fas system deficiency, although not in FAS Ligand, adversely affected survival in the long term in laryngeal cancer patients. |
| format | Article |
| id | doaj-art-d714e5bf24124bb59090d794bc8f4fdf |
| institution | OA Journals |
| issn | 2602-4837 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | The Turkish Journal of Ear Nose and Throat |
| spelling | doaj-art-d714e5bf24124bb59090d794bc8f4fdf2025-08-20T02:27:45ZengIstanbul University PressThe Turkish Journal of Ear Nose and Throat2602-48372022-06-01322374210.26650/Tr-ENT.2022.1039303123456A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After LaryngectomyAhmet Mert Bilgilihttps://orcid.org/0000-0003-2326-4511Tolga Ersözlü0https://orcid.org/0000-0001-8629-6022Namık Kemal Üniversitesi, Tekirdag, TurkiyeObjective: Larynx cancer constitutes 2% of all cancers in adults with 96% of larynx malignancies being squamous cell carcinoma (SHC). Apoptosis is a cell death mechanism that is quite different from necrosis. It is also known as programmed cell death, physiological cell death, or cell suicide. Physiological mediators that activate programmed cell death (apoptosis) are Fas and Fas Ligand (FasL). Materials and Methods: In a thesis study conducted by our authors in 2004, we investigated the relationship of Fas-Fas ligand-mediated apoptosis with survival in laryngeal cancer, prognostic factors (age, localization, histological grade, tumor size, lymph, blood vessel invasion), stage, and inflammatory response of the tumor. In this study, we investigated the relationship between survival and death rates after 20 years and Fas-FasL. Results: When FAS was evaluated 20 years later, a statistically significant difference was found between mortality rates depending on stage (p=0.023; p<0.05). While the survival rate is higher in stage 1 cases, the rate of death is higher in stage 3 cases. No statistically significant difference was found between mortality rates according to stages for FAS Ligand 20 years later (p>0.05). Conclusion: In conclusion, we found that the Fas/Fas-L system was not associated with clinical parameters in laryngeal cancers in our short-term follow-up. However, when we repeated our follow-up 20 years later, we found that Fas system deficiency, although not in FAS Ligand, adversely affected survival in the long term in laryngeal cancer patients.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/CF52E42E98E544A9978A157AD9EE79DBfasfas ligandlaryngectomylarynx cancersquamous cell tumor |
| spellingShingle | Ahmet Mert Bilgili Tolga Ersözlü A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy The Turkish Journal of Ear Nose and Throat fas fas ligand laryngectomy larynx cancer squamous cell tumor |
| title | A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy |
| title_full | A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy |
| title_fullStr | A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy |
| title_full_unstemmed | A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy |
| title_short | A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy |
| title_sort | comparison of fas fas ligand mediated apoptosis with clinical and pathological parameters in larynx cancers twenty years after laryngectomy |
| topic | fas fas ligand laryngectomy larynx cancer squamous cell tumor |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/CF52E42E98E544A9978A157AD9EE79DB |
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