INTERRELATION OF METABOLIC SYNDROME COMPONENTS WITH CELL AND VESSEL AGING PARAMETERS
Aim. To study the interrelation of different MS components and parameters of cell and vessel aging.Material and methods. Totally 136 patients studied with the age 25-75 y. without any signs of CVD or other chronic diseases, not receiving any continuous drug therapy. In all patients the antropometric...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2014-06-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/92 |
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| author | I. D. Strajesko O. N. Tkacheva D. U. Akasheva E. V. Dudinskaya M. V. Agaltsov A. S. Kruglikova N. V. Brailova V. S. Pykhtina E. V. Plokhova O. Yu. Isaykina V. A. Vygodin N. V. Gomyranova S. A. Boytsov |
| author_facet | I. D. Strajesko O. N. Tkacheva D. U. Akasheva E. V. Dudinskaya M. V. Agaltsov A. S. Kruglikova N. V. Brailova V. S. Pykhtina E. V. Plokhova O. Yu. Isaykina V. A. Vygodin N. V. Gomyranova S. A. Boytsov |
| author_sort | I. D. Strajesko |
| collection | DOAJ |
| description | Aim. To study the interrelation of different MS components and parameters of cell and vessel aging.Material and methods. Totally 136 patients studied with the age 25-75 y. without any signs of CVD or other chronic diseases, not receiving any continuous drug therapy. In all patients the antropometric parameters, BP levels, fasting plasma glucose, HDL cholesterol and triglycerides levels were measured. The PWV measurement was performed by the device SphygmoCor (AtCorMedical, Australia). Telomere length (TL) was measured by PCR.Results. Multidimensional regression analysis revealed that among all MS risk factors studied only the age (р=0,0003), waist circumference (р=0,0434), systolic BP (р=0,0001), НОМА-IR (р=0,0033), fasting glycemia (р=0,0001) and TL (р=0,0001) are the independent determinants of PWV, and this relation is reversed for TL, but direct — with the other parameters. Independent reversed relation is with TL only for age (р=0,0033) and НОМА-IR (р=0,0027).Concluson. Arterial hypertension can be named as the main hemodynamic component and impaired carbohydrate metabolism, insulin resistance and obesity as the main non-hemodynamic components of vessel wall rigidity increase and as the main target for therapeutical intervention. |
| format | Article |
| id | doaj-art-d70ef61408d749e89643667ddb0079f1 |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2014-06-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-d70ef61408d749e89643667ddb0079f12025-08-20T03:57:09Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202014-06-0106303410.15829/1560-4071-2014-6-30-3492INTERRELATION OF METABOLIC SYNDROME COMPONENTS WITH CELL AND VESSEL AGING PARAMETERSI. D. Strajesko0O. N. Tkacheva1D. U. Akasheva2E. V. Dudinskaya3M. V. Agaltsov4A. S. Kruglikova5N. V. Brailova6V. S. Pykhtina7E. V. Plokhova8O. Yu. Isaykina9V. A. Vygodin10N. V. Gomyranova11S. A. Boytsov12FSBI State Scientific-Research Centre for Preventive Medicine of the Ministry of Health, Moscow, Russia.FSBI State Scientific-Research Centre for Preventive Medicine of the Ministry of Health, Moscow, Russia.FSBI State Scientific-Research Centre for Preventive Medicine of the Ministry of Health, Moscow, Russia.FSBI State Scientific-Research Centre for Preventive Medicine of the Ministry of Health, Moscow, Russia.FSBI State Scientific-Research Centre for Preventive Medicine of the Ministry of Health, Moscow, Russia.FSBI State Scientific-Research Centre for Preventive Medicine of the Ministry of Health, Moscow, Russia.FSBI State Scientific-Research Centre for Preventive Medicine of the Ministry of Health, Moscow, Russia.FSBI State Scientific-Research Centre for Preventive Medicine of the Ministry of Health, Moscow, Russia.FSBI State Scientific-Research Centre for Preventive Medicine of the Ministry of Health, Moscow, Russia.FSBI State Scientific-Research Centre for Preventive Medicine of the Ministry of Health, Moscow, Russia.FSBI State Scientific-Research Centre for Preventive Medicine of the Ministry of Health, Moscow, Russia.FSBI State Scientific-Research Centre for Preventive Medicine of the Ministry of Health, Moscow, Russia.FSBI State Scientific-Research Centre for Preventive Medicine of the Ministry of Health, Moscow, Russia.Aim. To study the interrelation of different MS components and parameters of cell and vessel aging.Material and methods. Totally 136 patients studied with the age 25-75 y. without any signs of CVD or other chronic diseases, not receiving any continuous drug therapy. In all patients the antropometric parameters, BP levels, fasting plasma glucose, HDL cholesterol and triglycerides levels were measured. The PWV measurement was performed by the device SphygmoCor (AtCorMedical, Australia). Telomere length (TL) was measured by PCR.Results. Multidimensional regression analysis revealed that among all MS risk factors studied only the age (р=0,0003), waist circumference (р=0,0434), systolic BP (р=0,0001), НОМА-IR (р=0,0033), fasting glycemia (р=0,0001) and TL (р=0,0001) are the independent determinants of PWV, and this relation is reversed for TL, but direct — with the other parameters. Independent reversed relation is with TL only for age (р=0,0033) and НОМА-IR (р=0,0027).Concluson. Arterial hypertension can be named as the main hemodynamic component and impaired carbohydrate metabolism, insulin resistance and obesity as the main non-hemodynamic components of vessel wall rigidity increase and as the main target for therapeutical intervention.https://russjcardiol.elpub.ru/jour/article/view/92arterial stiffnesstelomere lengthmetabolic syndromeinsulin resistance |
| spellingShingle | I. D. Strajesko O. N. Tkacheva D. U. Akasheva E. V. Dudinskaya M. V. Agaltsov A. S. Kruglikova N. V. Brailova V. S. Pykhtina E. V. Plokhova O. Yu. Isaykina V. A. Vygodin N. V. Gomyranova S. A. Boytsov INTERRELATION OF METABOLIC SYNDROME COMPONENTS WITH CELL AND VESSEL AGING PARAMETERS Российский кардиологический журнал arterial stiffness telomere length metabolic syndrome insulin resistance |
| title | INTERRELATION OF METABOLIC SYNDROME COMPONENTS WITH CELL AND VESSEL AGING PARAMETERS |
| title_full | INTERRELATION OF METABOLIC SYNDROME COMPONENTS WITH CELL AND VESSEL AGING PARAMETERS |
| title_fullStr | INTERRELATION OF METABOLIC SYNDROME COMPONENTS WITH CELL AND VESSEL AGING PARAMETERS |
| title_full_unstemmed | INTERRELATION OF METABOLIC SYNDROME COMPONENTS WITH CELL AND VESSEL AGING PARAMETERS |
| title_short | INTERRELATION OF METABOLIC SYNDROME COMPONENTS WITH CELL AND VESSEL AGING PARAMETERS |
| title_sort | interrelation of metabolic syndrome components with cell and vessel aging parameters |
| topic | arterial stiffness telomere length metabolic syndrome insulin resistance |
| url | https://russjcardiol.elpub.ru/jour/article/view/92 |
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