Genomic and clinical characterization of HER2 exon 20 mutations in non-small cell lung cancer: insights from a multicenter study in South China

Genomic and clinical characterization of HER2 exon 20 mutations in non-small cell lung cancer: insights from a multicenter study in South China

Abstract Background The objective of this study was to investigate the clinical and genetic characteristics and clinical relevance of HER2 exon 20 oncogenic variants in non-small cell lung cancer (NSCLC) patients. Methods This prospective study analyzed 51 NSCLC patients with HER2 mutations, identif...

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Bibliographic Details
Main Authors: Yating Hou, Xingyang Xue, Zhuoyun Zhang, Dahai Mai, Wei Luo, Mingyu Zhou, Zichuan Liu, Yisheng Huang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Cancer
Subjects:
HER2 oncogenic variants
Non-small cell lung cancer (NSCLC)
Exon 20 mutations
Metastasis
Targeted therapies
Gene ontology (GO) analysis
Online Access:https://doi.org/10.1186/s12885-025-14125-9
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