A 14-Year Analysis of Breast Cancer Risk Factors and Its Determinants of Mortality in Rural Southwestern Nigeria

Background: Research on breast cancer risk factors and mortality is gaining recognition and attention globally; there is need to add more information on its determinants among patients admitted in hospital. Some studies on risk factors and mortality of breast cancer in Nigeria hospitals conducted in...

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Main Authors: Azeez Oyemomi Ibrahim, Adetunji Omonijo, Tosin Anthony Agbesanwa, Ayodele Kamal Alabi, Olayide Toyin Elegbede, Kolawole Michael Olusuyi, Musah Yusuf, Eniola Ayoyemi Afolabi-Obe, Olagoke Erinomo, Olakunle Fatai Babalola, Henry Abiyere, Olayinka Tesleem Orewole, Shuaib Kayode Aremu
Format: Article
Language:English
Published: SAGE Publishing 2024-11-01
Series:Clinical Medicine Insights: Oncology
Online Access:https://doi.org/10.1177/11795549241288197
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author Azeez Oyemomi Ibrahim
Adetunji Omonijo
Tosin Anthony Agbesanwa
Ayodele Kamal Alabi
Olayide Toyin Elegbede
Kolawole Michael Olusuyi
Musah Yusuf
Eniola Ayoyemi Afolabi-Obe
Olagoke Erinomo
Olakunle Fatai Babalola
Henry Abiyere
Olayinka Tesleem Orewole
Shuaib Kayode Aremu
author_facet Azeez Oyemomi Ibrahim
Adetunji Omonijo
Tosin Anthony Agbesanwa
Ayodele Kamal Alabi
Olayide Toyin Elegbede
Kolawole Michael Olusuyi
Musah Yusuf
Eniola Ayoyemi Afolabi-Obe
Olagoke Erinomo
Olakunle Fatai Babalola
Henry Abiyere
Olayinka Tesleem Orewole
Shuaib Kayode Aremu
author_sort Azeez Oyemomi Ibrahim
collection DOAJ
description Background: Research on breast cancer risk factors and mortality is gaining recognition and attention globally; there is need to add more information on its determinants among patients admitted in hospital. Some studies on risk factors and mortality of breast cancer in Nigeria hospitals conducted in the urban and suburban areas have been documented. Therefore, an addition of a study conducted in the setting of a rural health institution is necessary. This study assessed the risk factors and determinants of mortality among patients admitted for breast cancer in rural Southwestern Nigeria. Methods: A retrospective observational study was conducted on 260 patients who were admitted for breast cancer between January 2010 and December 2023 using a data form and a standardized information form. The data were analyzed using SPSS version 22.0. The risk factors and the determinants of mortality of patients with breast cancer were identified using multivariate regression model. Results: The breast cancer risk factors were old age, family history, tobacco smoking, combined oral contraceptives, and hormonal therapy use. The case fatality rate was 38.1%, and its determinants of mortality were patients who were older (adjusted odds ratio [AOR], 1.956; 95% confidence interval [CI]:1.341-4.333), obese (AOR, 2.635; 95% CI: 1.485-6.778), stage IV (AOR, 1.895; 95% CI: 1.146-8.9742), mastectomy (AOR, 2.512; 95% CI: 1.003-6.569), discontinued adjuvant chemotherapy (AOR, 1.785; 95% CI: 1.092-4.6311), and yet to commence adjuvant chemotherapy (AOR, 2.568; 95% CI: 1.367-5.002). Conclusion: The study revealed that patients with breast cancer were associated with high mortality. Sustained health education to promote early diagnosis, managed co-morbidities, and access to treatment may contribute to reduction in breast cancer mortality in rural Nigeria.
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spelling doaj-art-d70ac7b2c3b241388a321e6a2933d1fb2025-08-20T02:17:59ZengSAGE PublishingClinical Medicine Insights: Oncology1179-55492024-11-011810.1177/11795549241288197A 14-Year Analysis of Breast Cancer Risk Factors and Its Determinants of Mortality in Rural Southwestern NigeriaAzeez Oyemomi Ibrahim0Adetunji Omonijo1Tosin Anthony Agbesanwa2Ayodele Kamal Alabi3Olayide Toyin Elegbede4Kolawole Michael Olusuyi5Musah Yusuf6Eniola Ayoyemi Afolabi-Obe7Olagoke Erinomo8Olakunle Fatai Babalola9Henry Abiyere10Olayinka Tesleem Orewole11Shuaib Kayode Aremu12Department of Family Medicine, Afe Babalola University, Ado Ekiti, NigeriaDepartment of Family Medicine, Federal Teaching Hospital Ido-Ekiti, Ido-Ekiti, NigeriaDepartment of Family Medicine, Ekiti State University, Ado-Ekiti, NigeriaDepartment of Community Medicine, Federal Teaching Hospital Ido-Ekiti, Ido-Ekiti, NigeriaDepartment of Family Medicine, Afe Babalola University, Ado Ekiti, NigeriaDepartment of Family Medicine, Afe Babalola University, Ado Ekiti, NigeriaDepartment of Medicine, Afe Babalola University, Ado-Ekiti, NigeriaDepartment of Family Medicine, Lagos State University Teaching Hospital, Ikeja, NigeriaDepartment of Pathology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, NigeriaDepartment of Surgery, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, NigeriaDepartment of Surgery, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, NigeriaDepartment of Anaesthesia, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, NigeriaDepartment of Otorhinolaryngology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, NigeriaBackground: Research on breast cancer risk factors and mortality is gaining recognition and attention globally; there is need to add more information on its determinants among patients admitted in hospital. Some studies on risk factors and mortality of breast cancer in Nigeria hospitals conducted in the urban and suburban areas have been documented. Therefore, an addition of a study conducted in the setting of a rural health institution is necessary. This study assessed the risk factors and determinants of mortality among patients admitted for breast cancer in rural Southwestern Nigeria. Methods: A retrospective observational study was conducted on 260 patients who were admitted for breast cancer between January 2010 and December 2023 using a data form and a standardized information form. The data were analyzed using SPSS version 22.0. The risk factors and the determinants of mortality of patients with breast cancer were identified using multivariate regression model. Results: The breast cancer risk factors were old age, family history, tobacco smoking, combined oral contraceptives, and hormonal therapy use. The case fatality rate was 38.1%, and its determinants of mortality were patients who were older (adjusted odds ratio [AOR], 1.956; 95% confidence interval [CI]:1.341-4.333), obese (AOR, 2.635; 95% CI: 1.485-6.778), stage IV (AOR, 1.895; 95% CI: 1.146-8.9742), mastectomy (AOR, 2.512; 95% CI: 1.003-6.569), discontinued adjuvant chemotherapy (AOR, 1.785; 95% CI: 1.092-4.6311), and yet to commence adjuvant chemotherapy (AOR, 2.568; 95% CI: 1.367-5.002). Conclusion: The study revealed that patients with breast cancer were associated with high mortality. Sustained health education to promote early diagnosis, managed co-morbidities, and access to treatment may contribute to reduction in breast cancer mortality in rural Nigeria.https://doi.org/10.1177/11795549241288197
spellingShingle Azeez Oyemomi Ibrahim
Adetunji Omonijo
Tosin Anthony Agbesanwa
Ayodele Kamal Alabi
Olayide Toyin Elegbede
Kolawole Michael Olusuyi
Musah Yusuf
Eniola Ayoyemi Afolabi-Obe
Olagoke Erinomo
Olakunle Fatai Babalola
Henry Abiyere
Olayinka Tesleem Orewole
Shuaib Kayode Aremu
A 14-Year Analysis of Breast Cancer Risk Factors and Its Determinants of Mortality in Rural Southwestern Nigeria
Clinical Medicine Insights: Oncology
title A 14-Year Analysis of Breast Cancer Risk Factors and Its Determinants of Mortality in Rural Southwestern Nigeria
title_full A 14-Year Analysis of Breast Cancer Risk Factors and Its Determinants of Mortality in Rural Southwestern Nigeria
title_fullStr A 14-Year Analysis of Breast Cancer Risk Factors and Its Determinants of Mortality in Rural Southwestern Nigeria
title_full_unstemmed A 14-Year Analysis of Breast Cancer Risk Factors and Its Determinants of Mortality in Rural Southwestern Nigeria
title_short A 14-Year Analysis of Breast Cancer Risk Factors and Its Determinants of Mortality in Rural Southwestern Nigeria
title_sort 14 year analysis of breast cancer risk factors and its determinants of mortality in rural southwestern nigeria
url https://doi.org/10.1177/11795549241288197
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