Computational simulations of tumor growth and treatment response: Benefits of high-frequency, low-dose drug regimens and concurrent vascular normalization.

Implementation of effective cancer treatment strategies requires consideration of how the spatiotemporal heterogeneities within the tumor microenvironment (TME) influence tumor progression and treatment response. Here, we developed a multi-scale three-dimensional mathematical model of the TME to sim...

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Bibliographic Details
Main Authors: Mohammad R Nikmaneshi, Rakesh K Jain, Lance L Munn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-06-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1011131
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