The prevalence and molecular basis of beta-thalassemia in Isparta province and region
The prevalence and molecular basis of beta-thalassemia in the district of Isparta were determined in a total of 6,054 healthy high school students who were recruited from 21 randomly selected high schools in the Isparta province and region. In 182 subjects, naked eye single tube red cell osmo...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2002-01-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/2930 |
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| author | Bahattin Tunç Hasan Cetin Fatma Gümrük Beysun Istanbullu Hasan Yavrucuoğlu Umran Kurt Halide Genç |
| author_facet | Bahattin Tunç Hasan Cetin Fatma Gümrük Beysun Istanbullu Hasan Yavrucuoğlu Umran Kurt Halide Genç |
| author_sort | Bahattin Tunç |
| collection | DOAJ |
| description |
The prevalence and molecular basis of beta-thalassemia in the district of Isparta were determined in a total of 6,054 healthy high school students who were recruited from 21 randomly selected high schools in the Isparta province and region. In 182 subjects, naked eye single tube red cell osmotic fragility test (NESTROFT test) was positive HbA2 was measured by high-performance liquid chromatography (HPLC) in these subjects and was found to be high in 149 subjects. The incidence of beta-thalassemia was 149 in 6,054 (25%). The beta-thalassemia frequency was lower in the city center than in neighboring towns, 1.7% vs. 2.2%, respectively The most prevalent mutation of beta-thalassemia in this region was IVS 1-110 (G-A), followed by Codon 39 (C-T) and IVSII-745 (C-G).
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| format | Article |
| id | doaj-art-d708330afbc44c2abb00e1f373ed3a5a |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-d708330afbc44c2abb00e1f373ed3a5a2025-08-20T02:59:42ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212002-01-01441The prevalence and molecular basis of beta-thalassemia in Isparta province and regionBahattin Tunç0Hasan CetinFatma GümrükBeysun IstanbulluHasan YavrucuoğluUmran KurtHalide GençDepartment of Pediatrics, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey. The prevalence and molecular basis of beta-thalassemia in the district of Isparta were determined in a total of 6,054 healthy high school students who were recruited from 21 randomly selected high schools in the Isparta province and region. In 182 subjects, naked eye single tube red cell osmotic fragility test (NESTROFT test) was positive HbA2 was measured by high-performance liquid chromatography (HPLC) in these subjects and was found to be high in 149 subjects. The incidence of beta-thalassemia was 149 in 6,054 (25%). The beta-thalassemia frequency was lower in the city center than in neighboring towns, 1.7% vs. 2.2%, respectively The most prevalent mutation of beta-thalassemia in this region was IVS 1-110 (G-A), followed by Codon 39 (C-T) and IVSII-745 (C-G). https://turkjpediatr.org/article/view/2930 |
| spellingShingle | Bahattin Tunç Hasan Cetin Fatma Gümrük Beysun Istanbullu Hasan Yavrucuoğlu Umran Kurt Halide Genç The prevalence and molecular basis of beta-thalassemia in Isparta province and region The Turkish Journal of Pediatrics |
| title | The prevalence and molecular basis of beta-thalassemia in Isparta province and region |
| title_full | The prevalence and molecular basis of beta-thalassemia in Isparta province and region |
| title_fullStr | The prevalence and molecular basis of beta-thalassemia in Isparta province and region |
| title_full_unstemmed | The prevalence and molecular basis of beta-thalassemia in Isparta province and region |
| title_short | The prevalence and molecular basis of beta-thalassemia in Isparta province and region |
| title_sort | prevalence and molecular basis of beta thalassemia in isparta province and region |
| url | https://turkjpediatr.org/article/view/2930 |
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