Case report: From misdiagnosis to timely detection: a clinical and imaging guide to neurological presentations of diffuse large B-cell lymphoma—insights from six cases
BackgroundThe clinical spectrum of diffuse large B-cell lymphoma (DLBCL) is notably heterogeneous. Some DLBCL patients initially present with neurological manifestations, leading to their preliminary diagnosis within neurology departments. However, the overlap of clinical and auxiliary examination f...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1410953/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860992730202112 |
|---|---|
| author | Chunxiao Yang Zihua Gong Tao Wang Huijuan Yuan Weinan Na Wei Xie Shengyuan Yu |
| author_facet | Chunxiao Yang Zihua Gong Tao Wang Huijuan Yuan Weinan Na Wei Xie Shengyuan Yu |
| author_sort | Chunxiao Yang |
| collection | DOAJ |
| description | BackgroundThe clinical spectrum of diffuse large B-cell lymphoma (DLBCL) is notably heterogeneous. Some DLBCL patients initially present with neurological manifestations, leading to their preliminary diagnosis within neurology departments. However, the overlap of clinical and auxiliary examination findings with those of various neurological entities—such as cerebral infarction, demyelination, viral encephalitis, and peripheral neuropathy—often results in diagnostic misattribution.Case presentationWe delineate six pathologically-confirmed DLBCL cases, each heralded by neurological deficits, including limb paresis, sensory loss, vertigo, seizure activity, and aphasia. These presentations precipitated multiple erroneous diagnoses pertaining to nervous system pathologies, culminating in a median diagnostic latency of 8 months.ConclusionThe differential diagnostic process for the misdiagnosed conditions in these cases has been meticulously revisited, enhancing the diagnostic acumen of neurologists. These cases underscore the imperative for neurologists to maintain a high index of suspicion for lymphoma in atypical presentations and to judiciously integrate multimodal diagnostic modalities—such as comprehensive imaging, cerebrospinal fluid analysis, and biopsy—to expedite diagnosis and initiate timely intervention. |
| format | Article |
| id | doaj-art-d7081cd6466543d2a99990e049bc9cd9 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-d7081cd6466543d2a99990e049bc9cd92025-02-10T06:49:08ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.14109531410953Case report: From misdiagnosis to timely detection: a clinical and imaging guide to neurological presentations of diffuse large B-cell lymphoma—insights from six casesChunxiao Yang0Zihua Gong1Tao Wang2Huijuan Yuan3Weinan Na4Wei Xie5Shengyuan Yu6Department of Neurology, The Second Medical Center, Chinese People’s Liberation Army (PLA) General Hospital, Beijing, ChinaDepartm ent of Neurology, Bethune International Peace Hospital, Shijiazhuang, Hebei, ChinaDepartment of Critical Care Medicine, The Fourth Medical Center, Chinese People’s Liberation Army (PLA) General Hospital, Beijing, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaDepartment of Neurology, The First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaDepartment of Neurology, The First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaBackgroundThe clinical spectrum of diffuse large B-cell lymphoma (DLBCL) is notably heterogeneous. Some DLBCL patients initially present with neurological manifestations, leading to their preliminary diagnosis within neurology departments. However, the overlap of clinical and auxiliary examination findings with those of various neurological entities—such as cerebral infarction, demyelination, viral encephalitis, and peripheral neuropathy—often results in diagnostic misattribution.Case presentationWe delineate six pathologically-confirmed DLBCL cases, each heralded by neurological deficits, including limb paresis, sensory loss, vertigo, seizure activity, and aphasia. These presentations precipitated multiple erroneous diagnoses pertaining to nervous system pathologies, culminating in a median diagnostic latency of 8 months.ConclusionThe differential diagnostic process for the misdiagnosed conditions in these cases has been meticulously revisited, enhancing the diagnostic acumen of neurologists. These cases underscore the imperative for neurologists to maintain a high index of suspicion for lymphoma in atypical presentations and to judiciously integrate multimodal diagnostic modalities—such as comprehensive imaging, cerebrospinal fluid analysis, and biopsy—to expedite diagnosis and initiate timely intervention.https://www.frontiersin.org/articles/10.3389/fonc.2025.1410953/fullDLBCLPCNSLneurological symptomsmisdiagnosiscase report |
| spellingShingle | Chunxiao Yang Zihua Gong Tao Wang Huijuan Yuan Weinan Na Wei Xie Shengyuan Yu Case report: From misdiagnosis to timely detection: a clinical and imaging guide to neurological presentations of diffuse large B-cell lymphoma—insights from six cases Frontiers in Oncology DLBCL PCNSL neurological symptoms misdiagnosis case report |
| title | Case report: From misdiagnosis to timely detection: a clinical and imaging guide to neurological presentations of diffuse large B-cell lymphoma—insights from six cases |
| title_full | Case report: From misdiagnosis to timely detection: a clinical and imaging guide to neurological presentations of diffuse large B-cell lymphoma—insights from six cases |
| title_fullStr | Case report: From misdiagnosis to timely detection: a clinical and imaging guide to neurological presentations of diffuse large B-cell lymphoma—insights from six cases |
| title_full_unstemmed | Case report: From misdiagnosis to timely detection: a clinical and imaging guide to neurological presentations of diffuse large B-cell lymphoma—insights from six cases |
| title_short | Case report: From misdiagnosis to timely detection: a clinical and imaging guide to neurological presentations of diffuse large B-cell lymphoma—insights from six cases |
| title_sort | case report from misdiagnosis to timely detection a clinical and imaging guide to neurological presentations of diffuse large b cell lymphoma insights from six cases |
| topic | DLBCL PCNSL neurological symptoms misdiagnosis case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1410953/full |
| work_keys_str_mv | AT chunxiaoyang casereportfrommisdiagnosistotimelydetectionaclinicalandimagingguidetoneurologicalpresentationsofdiffuselargebcelllymphomainsightsfromsixcases AT zihuagong casereportfrommisdiagnosistotimelydetectionaclinicalandimagingguidetoneurologicalpresentationsofdiffuselargebcelllymphomainsightsfromsixcases AT taowang casereportfrommisdiagnosistotimelydetectionaclinicalandimagingguidetoneurologicalpresentationsofdiffuselargebcelllymphomainsightsfromsixcases AT huijuanyuan casereportfrommisdiagnosistotimelydetectionaclinicalandimagingguidetoneurologicalpresentationsofdiffuselargebcelllymphomainsightsfromsixcases AT weinanna casereportfrommisdiagnosistotimelydetectionaclinicalandimagingguidetoneurologicalpresentationsofdiffuselargebcelllymphomainsightsfromsixcases AT weixie casereportfrommisdiagnosistotimelydetectionaclinicalandimagingguidetoneurologicalpresentationsofdiffuselargebcelllymphomainsightsfromsixcases AT shengyuanyu casereportfrommisdiagnosistotimelydetectionaclinicalandimagingguidetoneurologicalpresentationsofdiffuselargebcelllymphomainsightsfromsixcases |