Bispecific CAR-T cells targeting FAP and GPC3 have the potential to treat hepatocellular carcinoma

Bispecific CAR-T cells targeting FAP and GPC3 have the potential to treat hepatocellular carcinoma

Chimeric antigen receptor (CAR) T cell therapy has demonstrated robust efficacy against hematological malignancies, but there are still some challenges regarding treating solid tumors, including tumor heterogeneity, antigen escape, and an immunosuppressive microenvironment. Here, we found that SNU39...

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Bibliographic Details
Main Authors: Linfu Zhou, Yao Li, Diwei Zheng, Yongfang Zheng, Yuanbin Cui, Le Qin, Zhaoyang Tang, Dongdong Peng, Qiting Wu, Youguo Long, Yao Yao, Nathalie Wong, James Lau, Peng Li
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
hepatocellular carcinoma
FAP
GPC3
bispecific CAR-T cells
heterogeneity
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000596
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