Prevalence of mixed features in patients with first-episode depression: An exploratory multicentric study
Background and Aim: There is limited literature on the prevalence of mixed features in patients with depression, especially from countries in Asia. Our aim was to evaluate the prevalence of “mixed features” in patients with first-episode depression. Materials and Methods: Patients with first-episode...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-06-01
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| Series: | Indian Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_113_23 |
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| author | Sandeep Grover Swapnajeet Sahoo Kshirod K. Mishra Raman Deep Naresh Nebhinani Ranjan Bhattacharya Jitender Aneja Roy A. Kalivayalil Seshadri S. Chaterjee Vikas Menon Alka A. Subramanyam Varghese P. Punnoose Avinash Desouza Aseem Mehra BN Subodh Ajit Avasthi |
| author_facet | Sandeep Grover Swapnajeet Sahoo Kshirod K. Mishra Raman Deep Naresh Nebhinani Ranjan Bhattacharya Jitender Aneja Roy A. Kalivayalil Seshadri S. Chaterjee Vikas Menon Alka A. Subramanyam Varghese P. Punnoose Avinash Desouza Aseem Mehra BN Subodh Ajit Avasthi |
| author_sort | Sandeep Grover |
| collection | DOAJ |
| description | Background and Aim:
There is limited literature on the prevalence of mixed features in patients with depression, especially from countries in Asia. Our aim was to evaluate the prevalence of “mixed features” in patients with first-episode depression.
Materials and Methods:
Patients with first-episode depression were evaluated for the presence of mixed features as per the Diagnostic and Statistical Manual (DSM)-5 criteria. They were additionally evaluated on Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS).
Results:
About one-sixth (16%) of the patients fulfilled the DSM-5 criteria for the mixed features specifier. The most common manic/hypomanic clinical feature was increased talkativeness or pressure of speech, followed by elevated expansive mood (12.5%), and inflated self-esteem or grandiosity was the least common feature (8.7%). Those with mixed features had higher prevalence of comorbid tobacco dependence and psychotic symptoms. In terms of frequency of depressive symptoms as assessed on HDRS, compared to those without mixed features, those with mixed features had higher frequency of symptoms such as depressed mood, insomnia during early hours of morning, work and activities, agitation, gastrointestinal somatic symptoms, genital symptoms, hypochondriasis, and poorer insight.
Conclusion:
Mixed features specifier criteria were fulfilled by 16% patients with first-episode depression. This finding suggests that the extension of this specifier to depression can be considered as a useful step in understanding the symptom profile of patients with depression. |
| format | Article |
| id | doaj-art-d70369cec2e648559679a884988a0b3a |
| institution | Kabale University |
| issn | 0019-5545 1998-3794 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Psychiatry |
| spelling | doaj-art-d70369cec2e648559679a884988a0b3a2025-01-22T14:56:31ZengWolters Kluwer Medknow PublicationsIndian Journal of Psychiatry0019-55451998-37942023-06-0165667167910.4103/indianjpsychiatry.indianjpsychiatry_113_23Prevalence of mixed features in patients with first-episode depression: An exploratory multicentric studySandeep GroverSwapnajeet SahooKshirod K. MishraRaman DeepNaresh NebhinaniRanjan BhattacharyaJitender AnejaRoy A. KalivayalilSeshadri S. ChaterjeeVikas MenonAlka A. SubramanyamVarghese P. PunnooseAvinash DesouzaAseem MehraBN SubodhAjit AvasthiBackground and Aim: There is limited literature on the prevalence of mixed features in patients with depression, especially from countries in Asia. Our aim was to evaluate the prevalence of “mixed features” in patients with first-episode depression. Materials and Methods: Patients with first-episode depression were evaluated for the presence of mixed features as per the Diagnostic and Statistical Manual (DSM)-5 criteria. They were additionally evaluated on Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS). Results: About one-sixth (16%) of the patients fulfilled the DSM-5 criteria for the mixed features specifier. The most common manic/hypomanic clinical feature was increased talkativeness or pressure of speech, followed by elevated expansive mood (12.5%), and inflated self-esteem or grandiosity was the least common feature (8.7%). Those with mixed features had higher prevalence of comorbid tobacco dependence and psychotic symptoms. In terms of frequency of depressive symptoms as assessed on HDRS, compared to those without mixed features, those with mixed features had higher frequency of symptoms such as depressed mood, insomnia during early hours of morning, work and activities, agitation, gastrointestinal somatic symptoms, genital symptoms, hypochondriasis, and poorer insight. Conclusion: Mixed features specifier criteria were fulfilled by 16% patients with first-episode depression. This finding suggests that the extension of this specifier to depression can be considered as a useful step in understanding the symptom profile of patients with depression.https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_113_23depressionindiamixed features |
| spellingShingle | Sandeep Grover Swapnajeet Sahoo Kshirod K. Mishra Raman Deep Naresh Nebhinani Ranjan Bhattacharya Jitender Aneja Roy A. Kalivayalil Seshadri S. Chaterjee Vikas Menon Alka A. Subramanyam Varghese P. Punnoose Avinash Desouza Aseem Mehra BN Subodh Ajit Avasthi Prevalence of mixed features in patients with first-episode depression: An exploratory multicentric study Indian Journal of Psychiatry depression india mixed features |
| title | Prevalence of mixed features in patients with first-episode depression: An exploratory multicentric study |
| title_full | Prevalence of mixed features in patients with first-episode depression: An exploratory multicentric study |
| title_fullStr | Prevalence of mixed features in patients with first-episode depression: An exploratory multicentric study |
| title_full_unstemmed | Prevalence of mixed features in patients with first-episode depression: An exploratory multicentric study |
| title_short | Prevalence of mixed features in patients with first-episode depression: An exploratory multicentric study |
| title_sort | prevalence of mixed features in patients with first episode depression an exploratory multicentric study |
| topic | depression india mixed features |
| url | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_113_23 |
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