Prevalence of sarcopenia and its association with clinical features and health-related quality of life in Brazilian women with systemic lupus erythematosus
Objectives To assess the prevalence of sarcopenia and examine its association with clinical features, health-related quality of life (HRQoL), muscle-specific strength and body composition in patients with systemic lupus erythematosus (SLE).Methods In this cross-sectional multicentre study, women wit...
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BMJ Publishing Group
2025-05-01
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| Series: | Lupus Science and Medicine |
| Online Access: | https://lupus.bmj.com/content/12/1/e001447.full |
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| author | Vanessa Hax Poli Mara Spritzer Rosa Weiss Telles Rafaela Cavalheiro do Espirito Santo Emerson Pena Leonardo Peterson dos Santos Lucas Denardi Dória Stephanie Pilotti André Luiz Silveira Mallmann Daniel Nóbrega de Moraes Clarice Moura Mata Machado Cristina Costa Duarte Lanna Olivio Brito Malheiro Emanoel Luis da Silveira Fabiana de Miranda Moura Andrese Aline Gasparin Tayane Muniz Fighera Rafael Mendonça da Silva Chakr Ricardo Machado Xavier Odirlei André Monticielo |
| author_facet | Vanessa Hax Poli Mara Spritzer Rosa Weiss Telles Rafaela Cavalheiro do Espirito Santo Emerson Pena Leonardo Peterson dos Santos Lucas Denardi Dória Stephanie Pilotti André Luiz Silveira Mallmann Daniel Nóbrega de Moraes Clarice Moura Mata Machado Cristina Costa Duarte Lanna Olivio Brito Malheiro Emanoel Luis da Silveira Fabiana de Miranda Moura Andrese Aline Gasparin Tayane Muniz Fighera Rafael Mendonça da Silva Chakr Ricardo Machado Xavier Odirlei André Monticielo |
| author_sort | Vanessa Hax |
| collection | DOAJ |
| description | Objectives To assess the prevalence of sarcopenia and examine its association with clinical features, health-related quality of life (HRQoL), muscle-specific strength and body composition in patients with systemic lupus erythematosus (SLE).Methods In this cross-sectional multicentre study, women with SLE (18–50 years old) were included. Data collected included clinical features and HRQoL. Muscle strength was assessed using the handgrip test (kg), appendicular skeletal muscle mass index (ASMI, kg/m²) was measured using dual-energy X-ray absorptiometry. Physical performance was assessed using the timed-up-and-go test (TUG, seconds). Sarcopenia was defined by the European Working Group on Sarcopenia in Older People-2 criteria. The muscle-specific strength was evaluated by dividing their arm strength by their lean arm mass. Pearson’s or Spearman’s correlation coefficients were performed (accepted at p<0.05).Results Seventy-three SLE women were included, with median (IQR) age and disease duration of 37 (30–44) years old and 10.0 (4.0–16.8) years, respectively. Most of the patients (83.5%) had inactive or low disease activity and 31.0% presented a disease damage index score ≥1. Mean (±SD) handgrip strength, ASMI and muscle-specific strength was 25.58±8.31 kg, 6.62±0.97 kg/m² and 6.6±2.3, respectively. Median TUG was 6.9 (6.1–8.2) s. The prevalence of probable sarcopenia was 11.1%, and sarcopenia was 2.7%. Lower muscle strength, lower muscle-specific strength and lower physical performance, as well as sarcopenia, were correlated with worse HRQoL (p<0.05).Conclusion In Brazilian patients with SLE with inactive or low disease activity, the prevalence of sarcopenia was low. However, low muscle strength, low muscle-specific strength and low physical performance were correlated with worse HRQoL, emphasising the need for muscle strength assessments in SLE management. |
| format | Article |
| id | doaj-art-d700eaf466c046cea1d0f378f278ec1f |
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| issn | 2053-8790 |
| language | English |
| publishDate | 2025-05-01 |
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| series | Lupus Science and Medicine |
| spelling | doaj-art-d700eaf466c046cea1d0f378f278ec1f2025-08-20T02:56:10ZengBMJ Publishing GroupLupus Science and Medicine2053-87902025-05-0112110.1136/lupus-2024-001447Prevalence of sarcopenia and its association with clinical features and health-related quality of life in Brazilian women with systemic lupus erythematosusVanessa Hax0Poli Mara Spritzer1Rosa Weiss Telles2Rafaela Cavalheiro do Espirito Santo3Emerson Pena4Leonardo Peterson dos Santos5Lucas Denardi Dória6Stephanie Pilotti7André Luiz Silveira Mallmann8Daniel Nóbrega de Moraes9Clarice Moura Mata Machado10Cristina Costa Duarte Lanna11Olivio Brito Malheiro12Emanoel Luis da Silveira13Fabiana de Miranda Moura14Andrese Aline Gasparin15Tayane Muniz Fighera16Rafael Mendonça da Silva Chakr17Ricardo Machado Xavier18Odirlei André Monticielo19Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil2 Gynecological Endocrinology Unit, Endocrine Division, Hospital de Clinicas de Porto Alegre, Porto Alegre, BrazilHospital das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, BrazilHospital de Clinicas de Porto Alegre, Porto Alegre, BrazilHospital de Clinicas de Porto Alegre, Porto Alegre, BrazilHospital de Clinicas de Porto Alegre, Porto Alegre, BrazilHospital de Clinicas de Porto Alegre, Porto Alegre, BrazilHospital de Clinicas de Porto Alegre, Porto Alegre, BrazilHospital de Clinicas de Porto Alegre, Porto Alegre, BrazilHospital de Clinicas de Porto Alegre, Porto Alegre, BrazilHospital das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, BrazilHospital das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, BrazilHospital das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, BrazilUniversidade Federal de Minas Gerais, Belo Horizonte, BrazilLocomotor System Department, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilHospital de Clinicas de Porto Alegre, Porto Alegre, BrazilHospital de Clinicas de Porto Alegre, Porto Alegre, BrazilHospital de Clinicas de Porto Alegre, Porto Alegre, BrazilHospital de Clinicas de Porto Alegre, Porto Alegre, BrazilHospital de Clinicas de Porto Alegre, Porto Alegre, BrazilObjectives To assess the prevalence of sarcopenia and examine its association with clinical features, health-related quality of life (HRQoL), muscle-specific strength and body composition in patients with systemic lupus erythematosus (SLE).Methods In this cross-sectional multicentre study, women with SLE (18–50 years old) were included. Data collected included clinical features and HRQoL. Muscle strength was assessed using the handgrip test (kg), appendicular skeletal muscle mass index (ASMI, kg/m²) was measured using dual-energy X-ray absorptiometry. Physical performance was assessed using the timed-up-and-go test (TUG, seconds). Sarcopenia was defined by the European Working Group on Sarcopenia in Older People-2 criteria. The muscle-specific strength was evaluated by dividing their arm strength by their lean arm mass. Pearson’s or Spearman’s correlation coefficients were performed (accepted at p<0.05).Results Seventy-three SLE women were included, with median (IQR) age and disease duration of 37 (30–44) years old and 10.0 (4.0–16.8) years, respectively. Most of the patients (83.5%) had inactive or low disease activity and 31.0% presented a disease damage index score ≥1. Mean (±SD) handgrip strength, ASMI and muscle-specific strength was 25.58±8.31 kg, 6.62±0.97 kg/m² and 6.6±2.3, respectively. Median TUG was 6.9 (6.1–8.2) s. The prevalence of probable sarcopenia was 11.1%, and sarcopenia was 2.7%. Lower muscle strength, lower muscle-specific strength and lower physical performance, as well as sarcopenia, were correlated with worse HRQoL (p<0.05).Conclusion In Brazilian patients with SLE with inactive or low disease activity, the prevalence of sarcopenia was low. However, low muscle strength, low muscle-specific strength and low physical performance were correlated with worse HRQoL, emphasising the need for muscle strength assessments in SLE management.https://lupus.bmj.com/content/12/1/e001447.full |
| spellingShingle | Vanessa Hax Poli Mara Spritzer Rosa Weiss Telles Rafaela Cavalheiro do Espirito Santo Emerson Pena Leonardo Peterson dos Santos Lucas Denardi Dória Stephanie Pilotti André Luiz Silveira Mallmann Daniel Nóbrega de Moraes Clarice Moura Mata Machado Cristina Costa Duarte Lanna Olivio Brito Malheiro Emanoel Luis da Silveira Fabiana de Miranda Moura Andrese Aline Gasparin Tayane Muniz Fighera Rafael Mendonça da Silva Chakr Ricardo Machado Xavier Odirlei André Monticielo Prevalence of sarcopenia and its association with clinical features and health-related quality of life in Brazilian women with systemic lupus erythematosus Lupus Science and Medicine |
| title | Prevalence of sarcopenia and its association with clinical features and health-related quality of life in Brazilian women with systemic lupus erythematosus |
| title_full | Prevalence of sarcopenia and its association with clinical features and health-related quality of life in Brazilian women with systemic lupus erythematosus |
| title_fullStr | Prevalence of sarcopenia and its association with clinical features and health-related quality of life in Brazilian women with systemic lupus erythematosus |
| title_full_unstemmed | Prevalence of sarcopenia and its association with clinical features and health-related quality of life in Brazilian women with systemic lupus erythematosus |
| title_short | Prevalence of sarcopenia and its association with clinical features and health-related quality of life in Brazilian women with systemic lupus erythematosus |
| title_sort | prevalence of sarcopenia and its association with clinical features and health related quality of life in brazilian women with systemic lupus erythematosus |
| url | https://lupus.bmj.com/content/12/1/e001447.full |
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