Tissue features of lipid peroxidation in rats in conditions of the long-term influence of oxyethylized nonylphenols and their derivatives
The research of LPO state of white rats in conditions of the long-term influence of oxyethylized nonylphenols and their derivatives was carried out. It was established, that oxyethylized nonylphenols on day 45 of influence in the doses of 1/10 and 1/100 DL50 caused the increase of diene conjugates,...
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Dnipro State Medical University
2015-09-01
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| Series: | Medičnì Perspektivi |
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| Online Access: | http://medpers.dsma.dp.ua/issues/2015/N3/4-9.pdf |
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| author | Marakushin D.I. |
| author_facet | Marakushin D.I. |
| author_sort | Marakushin D.I. |
| collection | DOAJ |
| description | The research of LPO state of white rats in conditions of the long-term influence of oxyethylized nonylphenols and their derivatives was carried out. It was established, that oxyethylized nonylphenols on day 45 of influence in the doses of 1/10 and 1/100 DL50 caused the increase of diene conjugates, TBA-reactants, Schiff bases content in the blood, liver and brain gomogenate. The latter, because of a high reactogenic capability, probably, plays the role of a basic link limiting stability of an organism to the long-term influence of the studied compounds due to change of physicochemical properties of cellular membranes, activity of membrane-localized and lipid-depending enzymes, reactivity of neuroendocrine, immune and other systems of an organism. Intensification of LPO processes is one of the pathogenic links of the mechanisms of action of oxyethylized nonylphenols and their derivatives; this is necessary to take into account developing methods of their correction. |
| format | Article |
| id | doaj-art-d700adcd48aa4713b31df25a7f2e2686 |
| institution | DOAJ |
| issn | 2307-0404 2307-0404 |
| language | English |
| publishDate | 2015-09-01 |
| publisher | Dnipro State Medical University |
| record_format | Article |
| series | Medičnì Perspektivi |
| spelling | doaj-art-d700adcd48aa4713b31df25a7f2e26862025-08-20T02:51:02ZengDnipro State Medical UniversityMedičnì Perspektivi2307-04042307-04042015-09-0120349Tissue features of lipid peroxidation in rats in conditions of the long-term influence of oxyethylized nonylphenols and their derivatives Marakushin D.I. 0Kharkiv national medical universityThe research of LPO state of white rats in conditions of the long-term influence of oxyethylized nonylphenols and their derivatives was carried out. It was established, that oxyethylized nonylphenols on day 45 of influence in the doses of 1/10 and 1/100 DL50 caused the increase of diene conjugates, TBA-reactants, Schiff bases content in the blood, liver and brain gomogenate. The latter, because of a high reactogenic capability, probably, plays the role of a basic link limiting stability of an organism to the long-term influence of the studied compounds due to change of physicochemical properties of cellular membranes, activity of membrane-localized and lipid-depending enzymes, reactivity of neuroendocrine, immune and other systems of an organism. Intensification of LPO processes is one of the pathogenic links of the mechanisms of action of oxyethylized nonylphenols and their derivatives; this is necessary to take into account developing methods of their correction.http://medpers.dsma.dp.ua/issues/2015/N3/4-9.pdfoxyethylized nonylphenolslipid peroxidationdiene conjugatesTBA-reactantsSchiff bases |
| spellingShingle | Marakushin D.I. Tissue features of lipid peroxidation in rats in conditions of the long-term influence of oxyethylized nonylphenols and their derivatives Medičnì Perspektivi oxyethylized nonylphenols lipid peroxidation diene conjugates TBA-reactants Schiff bases |
| title | Tissue features of lipid peroxidation in rats in conditions of the long-term influence of oxyethylized nonylphenols and their derivatives |
| title_full | Tissue features of lipid peroxidation in rats in conditions of the long-term influence of oxyethylized nonylphenols and their derivatives |
| title_fullStr | Tissue features of lipid peroxidation in rats in conditions of the long-term influence of oxyethylized nonylphenols and their derivatives |
| title_full_unstemmed | Tissue features of lipid peroxidation in rats in conditions of the long-term influence of oxyethylized nonylphenols and their derivatives |
| title_short | Tissue features of lipid peroxidation in rats in conditions of the long-term influence of oxyethylized nonylphenols and their derivatives |
| title_sort | tissue features of lipid peroxidation in rats in conditions of the long term influence of oxyethylized nonylphenols and their derivatives |
| topic | oxyethylized nonylphenols lipid peroxidation diene conjugates TBA-reactants Schiff bases |
| url | http://medpers.dsma.dp.ua/issues/2015/N3/4-9.pdf |
| work_keys_str_mv | AT marakushindi tissuefeaturesoflipidperoxidationinratsinconditionsofthelongterminfluenceofoxyethylizednonylphenolsandtheirderivatives |