598 Neutrophils propagate inflammation and fibrosis in primary sclerosing cholangitis

598 Neutrophils propagate inflammation and fibrosis in primary sclerosing cholangitis

Objectives/Goals: Primary sclerosing cholangitis (PSC) manifests with an inflammatory milieu that leads to fibrotic scarring of the liver. Human PSC liver bile ducts are enriched with neutrophils; however, their infiltration and functional role is unexplored. Our goal is to investigate the mechanism...

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Main Authors: Abid Anwar, Sofia Jerez Ortega, Maleeha Kalaiger, Kaitlin Friesland, Jordan Young, Amaury E. Tuerlinckx, Usman Yaqoob, Robert C. Huebert, Nidhi Jalan-Sakrikar
Format: Article
Language:English
Published: Cambridge University Press 2025-04-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S2059866124011646/type/journal_article
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