PANDEMIC INFLUENZA A (H1N1) PDM 09 IN THE SEASON 2015/2016: ANALYSIS OF FATAL OUTCOMES IN CHILDREN
The analysis of the characteristics of the current influenza A(H1N1) pdm 09 at 624 children in the 2015/2016 season. For severe illness (5%) characterized by short incubation period, lack of initial period, acute or acute onset with rapid development of multiorgan failure, prolonged febrile body tem...
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LLC "Diagnostics and Vaccines"
2017-03-01
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| Series: | Детские инфекции (Москва) |
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| Online Access: | https://detinf.elpub.ru/jour/article/view/276 |
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| author | V. N. Timchenko O. I. Afanas'eva E. A. Dondurey O. V. Bulina V. S. Afanas'eva L. M. Pochinyaeva E. F. Gorbunov |
| author_facet | V. N. Timchenko O. I. Afanas'eva E. A. Dondurey O. V. Bulina V. S. Afanas'eva L. M. Pochinyaeva E. F. Gorbunov |
| author_sort | V. N. Timchenko |
| collection | DOAJ |
| description | The analysis of the characteristics of the current influenza A(H1N1) pdm 09 at 624 children in the 2015/2016 season. For severe illness (5%) characterized by short incubation period, lack of initial period, acute or acute onset with rapid development of multiorgan failure, prolonged febrile body temperature (up to 5—6 days or more) in the absence of complications, a prolonged severe intoxication (4—5 days or more), a significant frequency of diarrhea syndrome (10,2%), hemorrhagic syndrome (5.3%), exacerbation of comorbidity (20%), combined with other viral infections — herpes, rotavirus, enterovirus and others (33%).In the clinical analysis of blood — leukopenia (33.9%), leukocytosis (14.5%) with neutrophilic shift (11.3%), neutrophilia (51.6%), monocytosis (45.2%), lymphocytosis (9.7%), thrombocytopenia, anemia, accelerated erythrocyte sedimentation rate moderately; in the biochemical analysis of blood, hypernatremia, increase in the concentration of lactate, hyperfermentemia (ALT, AST, ALP, LDH, CPK), hypoproteinemia, dysproteinemia, increased CRP, increased creatinine and urea, increase of procalcitonin (PCT). In the structure of complications of pneumonia was 6%, stenosing laryngotracheitis — 9.8%, obstructive bronchitis — 14.5%. Two unvaccinated against influenza in infants who become ill during the epidemic period for influenza and SARS from homes with a typical clinical picture, died from severe (toxic) form of pandemic influenza. Pandemic influenza occurred at the background of severe immunosuppression (atrophy of the thymus, depletion of follicles of peripheral organs of immunogenesis — spleen, lymph nodes, tonsils). The main cause of death was the development of multiple organ failure with rapid progressive lesion of the vital organs. |
| format | Article |
| id | doaj-art-d6fde5652c8e442abd3355a5c1b4aa2f |
| institution | OA Journals |
| issn | 2072-8107 |
| language | Russian |
| publishDate | 2017-03-01 |
| publisher | LLC "Diagnostics and Vaccines" |
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| series | Детские инфекции (Москва) |
| spelling | doaj-art-d6fde5652c8e442abd3355a5c1b4aa2f2025-08-20T02:03:14ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072017-03-01161364210.22627/2072-8107-2017-16-1-36-42269PANDEMIC INFLUENZA A (H1N1) PDM 09 IN THE SEASON 2015/2016: ANALYSIS OF FATAL OUTCOMES IN CHILDRENV. N. Timchenko0O. I. Afanas'eva1E. A. Dondurey2O. V. Bulina3V. S. Afanas'eva4L. M. Pochinyaeva5E. F. Gorbunov6SaintPetersburg State Pediatric Medical UniversityReseach Institute of Influenza, WHO National Influenza Centre of RussiaСhildren's City Clinical Hospital №5 after N.F. FilatovSaint Petersburg State Pediatric Medical UniversityReseach Institute of Influenza, WHO National Influenza Centre of RussiaСhildren's City Clinical Hospital №5 after N.F. FilatovСhildren's City Clinical Hospital №5 after N.F. FilatovThe analysis of the characteristics of the current influenza A(H1N1) pdm 09 at 624 children in the 2015/2016 season. For severe illness (5%) characterized by short incubation period, lack of initial period, acute or acute onset with rapid development of multiorgan failure, prolonged febrile body temperature (up to 5—6 days or more) in the absence of complications, a prolonged severe intoxication (4—5 days or more), a significant frequency of diarrhea syndrome (10,2%), hemorrhagic syndrome (5.3%), exacerbation of comorbidity (20%), combined with other viral infections — herpes, rotavirus, enterovirus and others (33%).In the clinical analysis of blood — leukopenia (33.9%), leukocytosis (14.5%) with neutrophilic shift (11.3%), neutrophilia (51.6%), monocytosis (45.2%), lymphocytosis (9.7%), thrombocytopenia, anemia, accelerated erythrocyte sedimentation rate moderately; in the biochemical analysis of blood, hypernatremia, increase in the concentration of lactate, hyperfermentemia (ALT, AST, ALP, LDH, CPK), hypoproteinemia, dysproteinemia, increased CRP, increased creatinine and urea, increase of procalcitonin (PCT). In the structure of complications of pneumonia was 6%, stenosing laryngotracheitis — 9.8%, obstructive bronchitis — 14.5%. Two unvaccinated against influenza in infants who become ill during the epidemic period for influenza and SARS from homes with a typical clinical picture, died from severe (toxic) form of pandemic influenza. Pandemic influenza occurred at the background of severe immunosuppression (atrophy of the thymus, depletion of follicles of peripheral organs of immunogenesis — spleen, lymph nodes, tonsils). The main cause of death was the development of multiple organ failure with rapid progressive lesion of the vital organs.https://detinf.elpub.ru/jour/article/view/276pandemic influenza a(h1n1) pdm 09severe (toxic) degreeinfantsmultiple organ failureimmunosuppressionlethal outcomes |
| spellingShingle | V. N. Timchenko O. I. Afanas'eva E. A. Dondurey O. V. Bulina V. S. Afanas'eva L. M. Pochinyaeva E. F. Gorbunov PANDEMIC INFLUENZA A (H1N1) PDM 09 IN THE SEASON 2015/2016: ANALYSIS OF FATAL OUTCOMES IN CHILDREN Детские инфекции (Москва) pandemic influenza a(h1n1) pdm 09 severe (toxic) degree infants multiple organ failure immunosuppression lethal outcomes |
| title | PANDEMIC INFLUENZA A (H1N1) PDM 09 IN THE SEASON 2015/2016: ANALYSIS OF FATAL OUTCOMES IN CHILDREN |
| title_full | PANDEMIC INFLUENZA A (H1N1) PDM 09 IN THE SEASON 2015/2016: ANALYSIS OF FATAL OUTCOMES IN CHILDREN |
| title_fullStr | PANDEMIC INFLUENZA A (H1N1) PDM 09 IN THE SEASON 2015/2016: ANALYSIS OF FATAL OUTCOMES IN CHILDREN |
| title_full_unstemmed | PANDEMIC INFLUENZA A (H1N1) PDM 09 IN THE SEASON 2015/2016: ANALYSIS OF FATAL OUTCOMES IN CHILDREN |
| title_short | PANDEMIC INFLUENZA A (H1N1) PDM 09 IN THE SEASON 2015/2016: ANALYSIS OF FATAL OUTCOMES IN CHILDREN |
| title_sort | pandemic influenza a h1n1 pdm 09 in the season 2015 2016 analysis of fatal outcomes in children |
| topic | pandemic influenza a(h1n1) pdm 09 severe (toxic) degree infants multiple organ failure immunosuppression lethal outcomes |
| url | https://detinf.elpub.ru/jour/article/view/276 |
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