Emerging mechanisms and implications of m6A in CVDs: potential applications of natural products
N6-methyladenosine (m6A) RNA methylation is the most common, abundant, and reversible epigenetic modification of RNAs, and it directs many essential processes in RNAs post-transcriptionally. It has been shown that m6A modification affects cardiovascular diseases (CVDs) by regulating RNA splicing, lo...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1559064/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850108670681022464 |
|---|---|
| author | Hui Wang Yun Zhang Xiao Jiang Guichun Liu Shujian Xu Jinbiao He Xudong He Ting Xiao Lijuan Wang LiJing Xiao Xinhui Li |
| author_facet | Hui Wang Yun Zhang Xiao Jiang Guichun Liu Shujian Xu Jinbiao He Xudong He Ting Xiao Lijuan Wang LiJing Xiao Xinhui Li |
| author_sort | Hui Wang |
| collection | DOAJ |
| description | N6-methyladenosine (m6A) RNA methylation is the most common, abundant, and reversible epigenetic modification of RNAs, and it directs many essential processes in RNAs post-transcriptionally. It has been shown that m6A modification affects cardiovascular diseases (CVDs) by regulating RNA splicing, localization, translation, and stabilization and regulating processes such as autophagy, apoptosis, inflammatory responses, and oxidative stress. A growing body of evidence has shown that natural products have the unique advantage of being highly effective with few side effects and have significant effects against CVDs. However, few studies have explored the relationship between natural products and m6A modification in the development of CVDs. In this review, we summarized the biological functions of m6A modification and discussed the potential mechanisms and processes of m6A modification in various CVDs; we also summarized the research progress of natural products modulating m6A modification in the treatment of CVDs. This review further elucidated the relationship between the modification of m6A methylation and CVDs, thereby contributing to the development of potential therapeutic agents from natural products. |
| format | Article |
| id | doaj-art-d6f7950bd1a14c09bbf6c88662db8f49 |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-d6f7950bd1a14c09bbf6c88662db8f492025-08-20T02:38:18ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-06-011210.3389/fcvm.2025.15590641559064Emerging mechanisms and implications of m6A in CVDs: potential applications of natural productsHui Wang0Yun Zhang1Xiao Jiang2Guichun Liu3Shujian Xu4Jinbiao He5Xudong He6Ting Xiao7Lijuan Wang8LiJing Xiao9Xinhui Li10The Second Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, ChinaThe First Clinical Medical College, Yunnan University of Traditional Chinese Medicine, Kunming, ChinaCollege of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaCollege of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaThe Second Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, ChinaYunnan Characteristic Plant Extraction Laboratory, School of Chemical Science and Technology, Yunnan University, Kunming, ChinaThe First Clinical Medical College, Yunnan University of Traditional Chinese Medicine, Kunming, ChinaThe Second Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, ChinaThe Second Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, ChinaThe Second Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, ChinaCollege of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaN6-methyladenosine (m6A) RNA methylation is the most common, abundant, and reversible epigenetic modification of RNAs, and it directs many essential processes in RNAs post-transcriptionally. It has been shown that m6A modification affects cardiovascular diseases (CVDs) by regulating RNA splicing, localization, translation, and stabilization and regulating processes such as autophagy, apoptosis, inflammatory responses, and oxidative stress. A growing body of evidence has shown that natural products have the unique advantage of being highly effective with few side effects and have significant effects against CVDs. However, few studies have explored the relationship between natural products and m6A modification in the development of CVDs. In this review, we summarized the biological functions of m6A modification and discussed the potential mechanisms and processes of m6A modification in various CVDs; we also summarized the research progress of natural products modulating m6A modification in the treatment of CVDs. This review further elucidated the relationship between the modification of m6A methylation and CVDs, thereby contributing to the development of potential therapeutic agents from natural products.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1559064/fullm6A methylationcardiovascular diseasesnatural productsbiological processesepigenetic modification |
| spellingShingle | Hui Wang Yun Zhang Xiao Jiang Guichun Liu Shujian Xu Jinbiao He Xudong He Ting Xiao Lijuan Wang LiJing Xiao Xinhui Li Emerging mechanisms and implications of m6A in CVDs: potential applications of natural products Frontiers in Cardiovascular Medicine m6A methylation cardiovascular diseases natural products biological processes epigenetic modification |
| title | Emerging mechanisms and implications of m6A in CVDs: potential applications of natural products |
| title_full | Emerging mechanisms and implications of m6A in CVDs: potential applications of natural products |
| title_fullStr | Emerging mechanisms and implications of m6A in CVDs: potential applications of natural products |
| title_full_unstemmed | Emerging mechanisms and implications of m6A in CVDs: potential applications of natural products |
| title_short | Emerging mechanisms and implications of m6A in CVDs: potential applications of natural products |
| title_sort | emerging mechanisms and implications of m6a in cvds potential applications of natural products |
| topic | m6A methylation cardiovascular diseases natural products biological processes epigenetic modification |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1559064/full |
| work_keys_str_mv | AT huiwang emergingmechanismsandimplicationsofm6aincvdspotentialapplicationsofnaturalproducts AT yunzhang emergingmechanismsandimplicationsofm6aincvdspotentialapplicationsofnaturalproducts AT xiaojiang emergingmechanismsandimplicationsofm6aincvdspotentialapplicationsofnaturalproducts AT guichunliu emergingmechanismsandimplicationsofm6aincvdspotentialapplicationsofnaturalproducts AT shujianxu emergingmechanismsandimplicationsofm6aincvdspotentialapplicationsofnaturalproducts AT jinbiaohe emergingmechanismsandimplicationsofm6aincvdspotentialapplicationsofnaturalproducts AT xudonghe emergingmechanismsandimplicationsofm6aincvdspotentialapplicationsofnaturalproducts AT tingxiao emergingmechanismsandimplicationsofm6aincvdspotentialapplicationsofnaturalproducts AT lijuanwang emergingmechanismsandimplicationsofm6aincvdspotentialapplicationsofnaturalproducts AT lijingxiao emergingmechanismsandimplicationsofm6aincvdspotentialapplicationsofnaturalproducts AT xinhuili emergingmechanismsandimplicationsofm6aincvdspotentialapplicationsofnaturalproducts |