Assembly and breakage of head-to-head double hexamer reveals mpox virus E5-catalyzed DNA unwinding initiation

Assembly and breakage of head-to-head double hexamer reveals mpox virus E5-catalyzed DNA unwinding initiation

Abstract The replicative helicase-catalyzed unwinding of the DNA double helix is the initiation of DNA replication. Helicases and primases are functionally related enzymes that have even been expressed as fusion proteins in some organisms and viruses. However, the mechanism underlying DNA unwinding...

Full description

Saved in:
Bibliographic Details
Main Authors: Yingxian Cheng, Pu Han, Qi Peng, Ruili Liu, Hao Liu, Bin Yuan, Yunfei Zhao, Lu Kuai, Jianxun Qi, Kai Miao, Yi Shi, George Fu Gao, Han Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60539-1
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items