Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis.
<h4>Introduction</h4>There are controversial results about the role of serum leptin and adiponectin levels as biomarkers of the severity of proteinuria in lupus nephritis.<h4>Objective</h4>The aim of this study was to evaluate the relationship between serum leptin and adipone...
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2017-01-01
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| author | Valeria Diaz-Rizo David Bonilla-Lara Laura Gonzalez-Lopez Dalia Sanchez-Mosco Nicte S Fajardo-Robledo Edsaul E Perez-Guerrero N Alejandra Rodriguez-Jimenez A Miriam Saldaña-Cruz M Luisa Vazquez-Villegas Eduardo Gomez-Bañuelos Monica Vazquez-Del Mercado E German Cardona-Muñoz David Cardona-Muller Xochitl Trujillo Xochitl Trujillo Miguel Huerta Mario Salazar-Paramo Jorge I Gamez-Nava |
| author_facet | Valeria Diaz-Rizo David Bonilla-Lara Laura Gonzalez-Lopez Dalia Sanchez-Mosco Nicte S Fajardo-Robledo Edsaul E Perez-Guerrero N Alejandra Rodriguez-Jimenez A Miriam Saldaña-Cruz M Luisa Vazquez-Villegas Eduardo Gomez-Bañuelos Monica Vazquez-Del Mercado E German Cardona-Muñoz David Cardona-Muller Xochitl Trujillo Xochitl Trujillo Miguel Huerta Mario Salazar-Paramo Jorge I Gamez-Nava |
| author_sort | Valeria Diaz-Rizo |
| collection | DOAJ |
| description | <h4>Introduction</h4>There are controversial results about the role of serum leptin and adiponectin levels as biomarkers of the severity of proteinuria in lupus nephritis.<h4>Objective</h4>The aim of this study was to evaluate the relationship between serum leptin and adiponectin levels with severity of proteinuria secondary to lupus nephritis (LN).<h4>Methods</h4>In a cross-sectional study, 103 women with systemic lupus erythematosus (SLE) were evaluated for kidney involvement. We compared 30 SLE patients with LN, all of them with proteinuria, versus 73 SLE patients without renal involvement (no LN). A comprehensive set of clinical and laboratory variables was assessed, including serum levels of leptin and adiponectin by ELISA. Multivariate analyses were used to adjust for potential confounders associated with proteinuria in LN.<h4>Results</h4>We found higher adiponectin levels in the LN group compared with the no LN group (20.4 ± 10.3 vs 15.6 ± 7.8 μg/mL; p = 0.02), whereas no differences were observed in leptin levels (33.3 ± 31.4 vs 22.5 ± 25.5 ng/mL; p = 0.07). Severity of proteinuria correlated with an increase in adiponectin levels (r = 0.31; p = 0.001), but no correlation was observed with leptin. Adiponectin levels were not related to anti-dsDNA or anti-nucleosome antibodies. In the logistic regression, adiponectin levels were associated with a high risk of proteinuria in SLE (OR = 1.06; 95% CI 1.01-1.12; p = 0.02). Instead, leptin was not associated with LN.<h4>Conclusion</h4>These findings indicate that adiponectin levels are useful markers associated with proteinuria in LN. Further longitudinal studies are required to identify if these levels are predictive of renal relapse. |
| format | Article |
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| institution | OA Journals |
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| spelling | doaj-art-d6f69041a206431d899cdaf1007b74eb2025-08-20T02:04:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01129e018405610.1371/journal.pone.0184056Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis.Valeria Diaz-RizoDavid Bonilla-LaraLaura Gonzalez-LopezDalia Sanchez-MoscoNicte S Fajardo-RobledoEdsaul E Perez-GuerreroN Alejandra Rodriguez-JimenezA Miriam Saldaña-CruzM Luisa Vazquez-VillegasEduardo Gomez-BañuelosMonica Vazquez-Del MercadoE German Cardona-MuñozDavid Cardona-MullerXochitl TrujilloXochitl TrujilloMiguel HuertaMario Salazar-ParamoJorge I Gamez-Nava<h4>Introduction</h4>There are controversial results about the role of serum leptin and adiponectin levels as biomarkers of the severity of proteinuria in lupus nephritis.<h4>Objective</h4>The aim of this study was to evaluate the relationship between serum leptin and adiponectin levels with severity of proteinuria secondary to lupus nephritis (LN).<h4>Methods</h4>In a cross-sectional study, 103 women with systemic lupus erythematosus (SLE) were evaluated for kidney involvement. We compared 30 SLE patients with LN, all of them with proteinuria, versus 73 SLE patients without renal involvement (no LN). A comprehensive set of clinical and laboratory variables was assessed, including serum levels of leptin and adiponectin by ELISA. Multivariate analyses were used to adjust for potential confounders associated with proteinuria in LN.<h4>Results</h4>We found higher adiponectin levels in the LN group compared with the no LN group (20.4 ± 10.3 vs 15.6 ± 7.8 μg/mL; p = 0.02), whereas no differences were observed in leptin levels (33.3 ± 31.4 vs 22.5 ± 25.5 ng/mL; p = 0.07). Severity of proteinuria correlated with an increase in adiponectin levels (r = 0.31; p = 0.001), but no correlation was observed with leptin. Adiponectin levels were not related to anti-dsDNA or anti-nucleosome antibodies. In the logistic regression, adiponectin levels were associated with a high risk of proteinuria in SLE (OR = 1.06; 95% CI 1.01-1.12; p = 0.02). Instead, leptin was not associated with LN.<h4>Conclusion</h4>These findings indicate that adiponectin levels are useful markers associated with proteinuria in LN. Further longitudinal studies are required to identify if these levels are predictive of renal relapse.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0184056&type=printable |
| spellingShingle | Valeria Diaz-Rizo David Bonilla-Lara Laura Gonzalez-Lopez Dalia Sanchez-Mosco Nicte S Fajardo-Robledo Edsaul E Perez-Guerrero N Alejandra Rodriguez-Jimenez A Miriam Saldaña-Cruz M Luisa Vazquez-Villegas Eduardo Gomez-Bañuelos Monica Vazquez-Del Mercado E German Cardona-Muñoz David Cardona-Muller Xochitl Trujillo Xochitl Trujillo Miguel Huerta Mario Salazar-Paramo Jorge I Gamez-Nava Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis. PLoS ONE |
| title | Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis. |
| title_full | Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis. |
| title_fullStr | Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis. |
| title_full_unstemmed | Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis. |
| title_short | Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis. |
| title_sort | serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0184056&type=printable |
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