Maternal Nutrition during Early Pregnancy and Cardiometabolic Status of Neonates at Birth
Objective. To explore the impact of maternal body weight on maternal nutrition and micronutrient status in early pregnancy and potential impact on metabolic status in newborns. Methodology. The EU FP7 project GIFTS was conducted from Jan 2012 to May 2014. Demographic details and anthropometric measu...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/7382946 |
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| author | Musarrat Riaz Fareeha Shaikh Asher Fawwad Rubina Hakeem A. Samad Shera Graham A. Hitman Bishwajit Bhowmik Nayla Christina do Vale Moreira Abdul Basit Akhtar Hussain |
| author_facet | Musarrat Riaz Fareeha Shaikh Asher Fawwad Rubina Hakeem A. Samad Shera Graham A. Hitman Bishwajit Bhowmik Nayla Christina do Vale Moreira Abdul Basit Akhtar Hussain |
| author_sort | Musarrat Riaz |
| collection | DOAJ |
| description | Objective. To explore the impact of maternal body weight on maternal nutrition and micronutrient status in early pregnancy and potential impact on metabolic status in newborns. Methodology. The EU FP7 project GIFTS was conducted from Jan 2012 to May 2014. Demographic details and anthropometric measurements of women in the first trimester of pregnancy were obtained. Blood samples were collected for OGTT, insulin, lipid profile, serum folate, ferritin, vitamin D, vitamin B12, and red cell folate. Newborn anthropometric characteristics were observed. Cord blood samples were collected after delivery for glucose, insulin, and lipid profile of newborns. Results. A total of 301 pregnant mothers, 108 overweight, 63 underweight, and 130 normal weight were included. Prevalence of vitamin D deficiency (<30 ng/mL) and low vitamin B12 (<190 ng/l) were high, 44% and 42%, respectively, in the first trimester. Anemic women (due to B12 or iron deficiency) were 79%, while 72% had low ferritin levels. Gestational diabetes was 16%. Differences were observed between underweight and overweight mothers (P<0.05) for fasting blood glucose, insulin levels, and serum ferritin were observed. No significant difference was observed between vitamin D, serum B12, and red cell folate levels. Conclusion. Prevalence of multiple micronutrient deficiencies was common among Pakistani women during early pregnancy despite the nonvegetarian diet that has important implications for pregnancy care in Pakistan and potentially in expatriate communities living abroad. This trial is registered with ISRCTN number 83599025. |
| format | Article |
| id | doaj-art-d6f5f5bc46ae496aa992863609e0b408 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-d6f5f5bc46ae496aa992863609e0b4082025-08-20T02:19:34ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/73829467382946Maternal Nutrition during Early Pregnancy and Cardiometabolic Status of Neonates at BirthMusarrat Riaz0Fareeha Shaikh1Asher Fawwad2Rubina Hakeem3A. Samad Shera4Graham A. Hitman5Bishwajit Bhowmik6Nayla Christina do Vale Moreira7Abdul Basit8Akhtar Hussain9Department of Medicine, Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, PakistanGIFTS Project, Karachi, PakistanDepartment of Biochemistry, Baqai Medical University, Karachi, PakistanDepartment of Research, Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, PakistanDiabetic Association of Pakistan, WHO Collaborating Centre, Karachi, PakistanBlizard Institute, Barts and The London School of Medicine and Dentistry Queen Mary University of London, London, UKDepartment of Community Medicine, Institute of Health and Society, University of Oslo, Oslo, NorwayDepartment of Community Medicine, Institute of Health and Society, University of Oslo, Oslo, NorwayDepartment of Medicine, Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, PakistanDepartment of Community Medicine, Institute of Health and Society, University of Oslo, Oslo, NorwayObjective. To explore the impact of maternal body weight on maternal nutrition and micronutrient status in early pregnancy and potential impact on metabolic status in newborns. Methodology. The EU FP7 project GIFTS was conducted from Jan 2012 to May 2014. Demographic details and anthropometric measurements of women in the first trimester of pregnancy were obtained. Blood samples were collected for OGTT, insulin, lipid profile, serum folate, ferritin, vitamin D, vitamin B12, and red cell folate. Newborn anthropometric characteristics were observed. Cord blood samples were collected after delivery for glucose, insulin, and lipid profile of newborns. Results. A total of 301 pregnant mothers, 108 overweight, 63 underweight, and 130 normal weight were included. Prevalence of vitamin D deficiency (<30 ng/mL) and low vitamin B12 (<190 ng/l) were high, 44% and 42%, respectively, in the first trimester. Anemic women (due to B12 or iron deficiency) were 79%, while 72% had low ferritin levels. Gestational diabetes was 16%. Differences were observed between underweight and overweight mothers (P<0.05) for fasting blood glucose, insulin levels, and serum ferritin were observed. No significant difference was observed between vitamin D, serum B12, and red cell folate levels. Conclusion. Prevalence of multiple micronutrient deficiencies was common among Pakistani women during early pregnancy despite the nonvegetarian diet that has important implications for pregnancy care in Pakistan and potentially in expatriate communities living abroad. This trial is registered with ISRCTN number 83599025.http://dx.doi.org/10.1155/2018/7382946 |
| spellingShingle | Musarrat Riaz Fareeha Shaikh Asher Fawwad Rubina Hakeem A. Samad Shera Graham A. Hitman Bishwajit Bhowmik Nayla Christina do Vale Moreira Abdul Basit Akhtar Hussain Maternal Nutrition during Early Pregnancy and Cardiometabolic Status of Neonates at Birth Journal of Diabetes Research |
| title | Maternal Nutrition during Early Pregnancy and Cardiometabolic Status of Neonates at Birth |
| title_full | Maternal Nutrition during Early Pregnancy and Cardiometabolic Status of Neonates at Birth |
| title_fullStr | Maternal Nutrition during Early Pregnancy and Cardiometabolic Status of Neonates at Birth |
| title_full_unstemmed | Maternal Nutrition during Early Pregnancy and Cardiometabolic Status of Neonates at Birth |
| title_short | Maternal Nutrition during Early Pregnancy and Cardiometabolic Status of Neonates at Birth |
| title_sort | maternal nutrition during early pregnancy and cardiometabolic status of neonates at birth |
| url | http://dx.doi.org/10.1155/2018/7382946 |
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