Beverage consumption modifies the risk of type 2 diabetes associated with ambient air pollution exposure
Background: Evidence on how beverage consumption modifies associations between air pollution (AP) exposure with the type 2 diabetes (T2D) risk remains scarce, which we aimed to investigate in this study. Methods: A total of 77,278 adults from the UK Biobank cohort were enrolled. Annual average conce...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325000752 |
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| author | Chaonan Fan Wenjuan Wang Wenxue Xiong Zhiyao Li Li Ling |
| author_facet | Chaonan Fan Wenjuan Wang Wenxue Xiong Zhiyao Li Li Ling |
| author_sort | Chaonan Fan |
| collection | DOAJ |
| description | Background: Evidence on how beverage consumption modifies associations between air pollution (AP) exposure with the type 2 diabetes (T2D) risk remains scarce, which we aimed to investigate in this study. Methods: A total of 77,278 adults from the UK Biobank cohort were enrolled. Annual average concentrations of fine particulate matter (PM2.5 and PM10) and nitrogen oxides (NO2 and NOX) were estimated to represent the long-term AP exposure using the land use regression model. The consumption of beverages (alcoholic beverages, juice, sugar-sweetened beverages [SSB], coffee, and tea) was estimated with the 24-hour dietary assessment. The AP-T2D and beverage-T2D risks were assessed using Cox regression models. Modifying effects of beverage consumption on AP-T2D associations were evaluated through stratified analysis and heterogeneity test. Results: During a median follow-up of 12.19 years, 1486 T2D events were recorded. One interquartile range increase of PM2.5, NO2, and NOX raised the T2D risk with the hazard ratios (HR) and 95 % confidence intervals (95 % CI) being 1.09 (1.03, 1.16), 1.14 (1.06, 1.21), and 1.09 (1.04, 1.15), respectively. For beverages, compared with non-consumption, daily consumption (>0 cup) of red wine, > 0–3 cups of white wine, ground coffee, and herbal tea, and > 0–1 cup of spirits were associated with a 13 %–37 % reduced T2D risk, while > 0 cup of SSB were associated with a 21 %-122 % elevated T2D risk. Beverage consumption modified AP-T2D associations, as compared with non-consumption, > 0–3 cups of red wine, white wine, ground coffee, and herbal tea had a lower attenuated T2D risk associated with NO2 and/or NOX. Conversely, those with > 1 cup of SSB had a higher T2D risk associated with both NO2 and NOX (Pheter <0.05). Conclusions: This study highlights the significant role of beverage consumption in mitigating or exacerbating the T2D risk associated with long-term NO2 and NOX exposure. |
| format | Article |
| id | doaj-art-d6f1f2cf3aa24a038ce3a190a1aba118 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-d6f1f2cf3aa24a038ce3a190a1aba1182025-02-12T05:30:09ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117739Beverage consumption modifies the risk of type 2 diabetes associated with ambient air pollution exposureChaonan Fan0Wenjuan Wang1Wenxue Xiong2Zhiyao Li3Li Ling4Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China; Division of Clinical Research Design, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Correspondence to: Department of Medical Statistics, School of Public Health, Sun Yat-sen University (North Campus), 74 Zhongshan Road II, Guangzhou, Guangdong 510080, China.Background: Evidence on how beverage consumption modifies associations between air pollution (AP) exposure with the type 2 diabetes (T2D) risk remains scarce, which we aimed to investigate in this study. Methods: A total of 77,278 adults from the UK Biobank cohort were enrolled. Annual average concentrations of fine particulate matter (PM2.5 and PM10) and nitrogen oxides (NO2 and NOX) were estimated to represent the long-term AP exposure using the land use regression model. The consumption of beverages (alcoholic beverages, juice, sugar-sweetened beverages [SSB], coffee, and tea) was estimated with the 24-hour dietary assessment. The AP-T2D and beverage-T2D risks were assessed using Cox regression models. Modifying effects of beverage consumption on AP-T2D associations were evaluated through stratified analysis and heterogeneity test. Results: During a median follow-up of 12.19 years, 1486 T2D events were recorded. One interquartile range increase of PM2.5, NO2, and NOX raised the T2D risk with the hazard ratios (HR) and 95 % confidence intervals (95 % CI) being 1.09 (1.03, 1.16), 1.14 (1.06, 1.21), and 1.09 (1.04, 1.15), respectively. For beverages, compared with non-consumption, daily consumption (>0 cup) of red wine, > 0–3 cups of white wine, ground coffee, and herbal tea, and > 0–1 cup of spirits were associated with a 13 %–37 % reduced T2D risk, while > 0 cup of SSB were associated with a 21 %-122 % elevated T2D risk. Beverage consumption modified AP-T2D associations, as compared with non-consumption, > 0–3 cups of red wine, white wine, ground coffee, and herbal tea had a lower attenuated T2D risk associated with NO2 and/or NOX. Conversely, those with > 1 cup of SSB had a higher T2D risk associated with both NO2 and NOX (Pheter <0.05). Conclusions: This study highlights the significant role of beverage consumption in mitigating or exacerbating the T2D risk associated with long-term NO2 and NOX exposure.http://www.sciencedirect.com/science/article/pii/S0147651325000752BeverageLong-termAir pollution exposureType 2 diabetesUK Biobank Cohort |
| spellingShingle | Chaonan Fan Wenjuan Wang Wenxue Xiong Zhiyao Li Li Ling Beverage consumption modifies the risk of type 2 diabetes associated with ambient air pollution exposure Ecotoxicology and Environmental Safety Beverage Long-term Air pollution exposure Type 2 diabetes UK Biobank Cohort |
| title | Beverage consumption modifies the risk of type 2 diabetes associated with ambient air pollution exposure |
| title_full | Beverage consumption modifies the risk of type 2 diabetes associated with ambient air pollution exposure |
| title_fullStr | Beverage consumption modifies the risk of type 2 diabetes associated with ambient air pollution exposure |
| title_full_unstemmed | Beverage consumption modifies the risk of type 2 diabetes associated with ambient air pollution exposure |
| title_short | Beverage consumption modifies the risk of type 2 diabetes associated with ambient air pollution exposure |
| title_sort | beverage consumption modifies the risk of type 2 diabetes associated with ambient air pollution exposure |
| topic | Beverage Long-term Air pollution exposure Type 2 diabetes UK Biobank Cohort |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325000752 |
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