Synthesis of acalabrutinib loaded β-cyclodextrin-based metal–organic frameworks as a potential material for breast cancer therapy
The current investigation successfully synthesized a porous β-cyclodextrin metal organic frameworks (βCD-MOFs). Herein, acalabrutinib (ACB) loaded βCD-MOFs (ACB-MOF) was engineered to improve the efficacy of ACB for the treatment of breast cancer. The ACB-MOF exhibited a particle size (627 nm) PDI (...
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Elsevier
2025-07-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715625004953 |
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| author | Mohammed F. Aldawsari Md. Khalid Anwer |
| author_facet | Mohammed F. Aldawsari Md. Khalid Anwer |
| author_sort | Mohammed F. Aldawsari |
| collection | DOAJ |
| description | The current investigation successfully synthesized a porous β-cyclodextrin metal organic frameworks (βCD-MOFs). Herein, acalabrutinib (ACB) loaded βCD-MOFs (ACB-MOF) was engineered to improve the efficacy of ACB for the treatment of breast cancer. The ACB-MOF exhibited a particle size (627 nm) PDI (0.245) and EE (79.25 %), respectively. The developed ACB-MOF was characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), thermogravimetric analyzer (TGA) and nitrogen gas adsorption. In-vitro release studies exhibited an improved stability and release pattern for 24 h, with korsmayer-peppas kinetics model. ACB-MOF exhibited improved cytotoxicity and lowered IC50 (11.68 μg/mL) against MCF7 cells as compared to pure-ACB (25.01 μg/mL). The ACB-MOF also improve the level of apoptotic markers significantly (P53, caspase-3 and caspase-9), indicating a promising delivery for breast cancer. |
| format | Article |
| id | doaj-art-d6f1bc9035c3413db30bef29170a42d3 |
| institution | DOAJ |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-d6f1bc9035c3413db30bef29170a42d32025-08-20T03:23:22ZengElsevierResults in Chemistry2211-71562025-07-011610251210.1016/j.rechem.2025.102512Synthesis of acalabrutinib loaded β-cyclodextrin-based metal–organic frameworks as a potential material for breast cancer therapyMohammed F. Aldawsari0Md. Khalid Anwer1Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, AlKharj 11942, Saudi ArabiaCorresponding author.; Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, AlKharj 11942, Saudi ArabiaThe current investigation successfully synthesized a porous β-cyclodextrin metal organic frameworks (βCD-MOFs). Herein, acalabrutinib (ACB) loaded βCD-MOFs (ACB-MOF) was engineered to improve the efficacy of ACB for the treatment of breast cancer. The ACB-MOF exhibited a particle size (627 nm) PDI (0.245) and EE (79.25 %), respectively. The developed ACB-MOF was characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), thermogravimetric analyzer (TGA) and nitrogen gas adsorption. In-vitro release studies exhibited an improved stability and release pattern for 24 h, with korsmayer-peppas kinetics model. ACB-MOF exhibited improved cytotoxicity and lowered IC50 (11.68 μg/mL) against MCF7 cells as compared to pure-ACB (25.01 μg/mL). The ACB-MOF also improve the level of apoptotic markers significantly (P53, caspase-3 and caspase-9), indicating a promising delivery for breast cancer.http://www.sciencedirect.com/science/article/pii/S2211715625004953AcalabrutinibCyclodextrinMetal organic frameworksCaspase- 3,9Breast cancer |
| spellingShingle | Mohammed F. Aldawsari Md. Khalid Anwer Synthesis of acalabrutinib loaded β-cyclodextrin-based metal–organic frameworks as a potential material for breast cancer therapy Results in Chemistry Acalabrutinib Cyclodextrin Metal organic frameworks Caspase- 3,9 Breast cancer |
| title | Synthesis of acalabrutinib loaded β-cyclodextrin-based metal–organic frameworks as a potential material for breast cancer therapy |
| title_full | Synthesis of acalabrutinib loaded β-cyclodextrin-based metal–organic frameworks as a potential material for breast cancer therapy |
| title_fullStr | Synthesis of acalabrutinib loaded β-cyclodextrin-based metal–organic frameworks as a potential material for breast cancer therapy |
| title_full_unstemmed | Synthesis of acalabrutinib loaded β-cyclodextrin-based metal–organic frameworks as a potential material for breast cancer therapy |
| title_short | Synthesis of acalabrutinib loaded β-cyclodextrin-based metal–organic frameworks as a potential material for breast cancer therapy |
| title_sort | synthesis of acalabrutinib loaded β cyclodextrin based metal organic frameworks as a potential material for breast cancer therapy |
| topic | Acalabrutinib Cyclodextrin Metal organic frameworks Caspase- 3,9 Breast cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2211715625004953 |
| work_keys_str_mv | AT mohammedfaldawsari synthesisofacalabrutinibloadedbcyclodextrinbasedmetalorganicframeworksasapotentialmaterialforbreastcancertherapy AT mdkhalidanwer synthesisofacalabrutinibloadedbcyclodextrinbasedmetalorganicframeworksasapotentialmaterialforbreastcancertherapy |