Design, synthesis and characterization of a new series of 2,3-dihydroquinazolin-4(1H)-one (DHQZ-1) derivatives and evaluation of antitumor resistant (by Molecule Docking)
The objective of this work is to use multicomponent reactions (MCRs) to produce a novel series of quinazoline derivatives with high yield. This occurs in one-pot condensation among Pyridine-3-carbaldehyde with 1H-3,1-benzoxazine-2,4-dione (Isatoic anhydride) and primary amines (3-7). The mixture re...
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University of Baghdad, College of Science for Women
2024-07-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8232 |
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| author | Mohammed Abed Kadhim Emad Khelil Mohammed Zangana Arkan Hassan Jawad |
| author_facet | Mohammed Abed Kadhim Emad Khelil Mohammed Zangana Arkan Hassan Jawad |
| author_sort | Mohammed Abed Kadhim |
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The objective of this work is to use multicomponent reactions (MCRs) to produce a novel series of quinazoline derivatives with high yield. This occurs in one-pot condensation among Pyridine-3-carbaldehyde with 1H-3,1-benzoxazine-2,4-dione (Isatoic anhydride) and primary amines (3-7). The mixture refluxed into tetrahydrofuran (THF, aprotic solvent). It is carried out with sodium hydrogen sulfate (NaHSO4) that is catalytically present, to afford a high yield of the 2,3-dihydroquinazolin-4(1H)-one derivative. The best yield has been obtained at 68°C. In general, all the products in the series (8-12) show a great ability as potent anticancer of the breast using a molecular docking study of the derivatives, point towards compound 11, it shows the greatest investigated as an anticancer of the breast activity than the other prepared compounds. The evaluation of molecular docking studies of derivatives is carried out via using Auto Dock 4.2 drug design software (PDB, protein code 1M17).
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| format | Article |
| id | doaj-art-d6ec6a14c08d4ac9b9c1c2deecc16524 |
| institution | DOAJ |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-d6ec6a14c08d4ac9b9c1c2deecc165242025-08-20T02:51:15ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862024-07-0121710.21123/bsj.2023.8232Design, synthesis and characterization of a new series of 2,3-dihydroquinazolin-4(1H)-one (DHQZ-1) derivatives and evaluation of antitumor resistant (by Molecule Docking)Mohammed Abed Kadhim0https://orcid.org/0000-0001-9096-7642Emad Khelil Mohammed Zangana1https://orcid.org/0000-0002-7829-0437Arkan Hassan Jawad2https://orcid.org/0000-0003-4372-1513Department of Chemistry, College of Science, University of Anbar, Iraq.Department of Chemistry, Faculty of Science and Health, Koya University , Koya45, Erbil, IraqThi-Qar Education Department, Thi-Qar, Iraq. The objective of this work is to use multicomponent reactions (MCRs) to produce a novel series of quinazoline derivatives with high yield. This occurs in one-pot condensation among Pyridine-3-carbaldehyde with 1H-3,1-benzoxazine-2,4-dione (Isatoic anhydride) and primary amines (3-7). The mixture refluxed into tetrahydrofuran (THF, aprotic solvent). It is carried out with sodium hydrogen sulfate (NaHSO4) that is catalytically present, to afford a high yield of the 2,3-dihydroquinazolin-4(1H)-one derivative. The best yield has been obtained at 68°C. In general, all the products in the series (8-12) show a great ability as potent anticancer of the breast using a molecular docking study of the derivatives, point towards compound 11, it shows the greatest investigated as an anticancer of the breast activity than the other prepared compounds. The evaluation of molecular docking studies of derivatives is carried out via using Auto Dock 4.2 drug design software (PDB, protein code 1M17). https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8232Antitumor resistant (protein 1M17), 2,3-Dihydroquinazolin4(1H)-one (DHQZ-1), Isatoic anhydride, Multi-component reactions (MCRs), Molecular Docking, Pyridine-3-carbaldehyde |
| spellingShingle | Mohammed Abed Kadhim Emad Khelil Mohammed Zangana Arkan Hassan Jawad Design, synthesis and characterization of a new series of 2,3-dihydroquinazolin-4(1H)-one (DHQZ-1) derivatives and evaluation of antitumor resistant (by Molecule Docking) مجلة بغداد للعلوم Antitumor resistant (protein 1M17), 2,3-Dihydroquinazolin4(1H)-one (DHQZ-1), Isatoic anhydride, Multi-component reactions (MCRs), Molecular Docking, Pyridine-3-carbaldehyde |
| title | Design, synthesis and characterization of a new series of 2,3-dihydroquinazolin-4(1H)-one (DHQZ-1) derivatives and evaluation of antitumor resistant (by Molecule Docking) |
| title_full | Design, synthesis and characterization of a new series of 2,3-dihydroquinazolin-4(1H)-one (DHQZ-1) derivatives and evaluation of antitumor resistant (by Molecule Docking) |
| title_fullStr | Design, synthesis and characterization of a new series of 2,3-dihydroquinazolin-4(1H)-one (DHQZ-1) derivatives and evaluation of antitumor resistant (by Molecule Docking) |
| title_full_unstemmed | Design, synthesis and characterization of a new series of 2,3-dihydroquinazolin-4(1H)-one (DHQZ-1) derivatives and evaluation of antitumor resistant (by Molecule Docking) |
| title_short | Design, synthesis and characterization of a new series of 2,3-dihydroquinazolin-4(1H)-one (DHQZ-1) derivatives and evaluation of antitumor resistant (by Molecule Docking) |
| title_sort | design synthesis and characterization of a new series of 2 3 dihydroquinazolin 4 1h one dhqz 1 derivatives and evaluation of antitumor resistant by molecule docking |
| topic | Antitumor resistant (protein 1M17), 2,3-Dihydroquinazolin4(1H)-one (DHQZ-1), Isatoic anhydride, Multi-component reactions (MCRs), Molecular Docking, Pyridine-3-carbaldehyde |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8232 |
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