Redox Imbalance in T Cell-Mediated Skin Diseases
The skin is permanently exposed to physical, chemical, and biological aggression by the environment. In addition, acute and chronic inflammatory events taking place in the skin are accompanied by abnormal release of pro-oxidative mediators. In this paper, we will briefly overview the homeostatic sys...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/861949 |
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| _version_ | 1850174987503140864 |
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| author | Saveria Pastore Liudmila Korkina |
| author_facet | Saveria Pastore Liudmila Korkina |
| author_sort | Saveria Pastore |
| collection | DOAJ |
| description | The skin is permanently exposed to physical, chemical, and biological aggression by the environment. In addition, acute and chronic inflammatory events taking place in the skin are accompanied by abnormal release of pro-oxidative mediators. In this paper, we will briefly overview the homeostatic systems active in the skin to maintain the redox balance and also to counteract abnormal oxidative stress. We will concentrate on the evidence that a local and/or systemic redox dysregulation accompanies the chronic inflammatory disorder events associated to psoriasis, contact dermatitis, and atopic dermatitis. We will also discuss the fact that several well-established treatments for the therapy of chronic inflammatory skin disorders are based on the application of strong physical or chemical oxidants onto the skin, indicating that, in selected conditions, a further increase of the oxidative imbalance may lead to a beneficial outcome. |
| format | Article |
| id | doaj-art-d6e798b0ff2b48808a1a9f5af17fa7fd |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d6e798b0ff2b48808a1a9f5af17fa7fd2025-08-20T02:19:33ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/861949861949Redox Imbalance in T Cell-Mediated Skin DiseasesSaveria Pastore0Liudmila Korkina1Laboratory of Tissue Engineering and Cutaneous Physiopathology, Istituto Dermopatico dell’Immacolata (IDI IRCCS), Via Monti di Creta 104, 00167 Rome, ItalyLaboratory of Tissue Engineering and Cutaneous Physiopathology, Istituto Dermopatico dell’Immacolata (IDI IRCCS), Via Monti di Creta 104, 00167 Rome, ItalyThe skin is permanently exposed to physical, chemical, and biological aggression by the environment. In addition, acute and chronic inflammatory events taking place in the skin are accompanied by abnormal release of pro-oxidative mediators. In this paper, we will briefly overview the homeostatic systems active in the skin to maintain the redox balance and also to counteract abnormal oxidative stress. We will concentrate on the evidence that a local and/or systemic redox dysregulation accompanies the chronic inflammatory disorder events associated to psoriasis, contact dermatitis, and atopic dermatitis. We will also discuss the fact that several well-established treatments for the therapy of chronic inflammatory skin disorders are based on the application of strong physical or chemical oxidants onto the skin, indicating that, in selected conditions, a further increase of the oxidative imbalance may lead to a beneficial outcome.http://dx.doi.org/10.1155/2010/861949 |
| spellingShingle | Saveria Pastore Liudmila Korkina Redox Imbalance in T Cell-Mediated Skin Diseases Mediators of Inflammation |
| title | Redox Imbalance in T Cell-Mediated Skin Diseases |
| title_full | Redox Imbalance in T Cell-Mediated Skin Diseases |
| title_fullStr | Redox Imbalance in T Cell-Mediated Skin Diseases |
| title_full_unstemmed | Redox Imbalance in T Cell-Mediated Skin Diseases |
| title_short | Redox Imbalance in T Cell-Mediated Skin Diseases |
| title_sort | redox imbalance in t cell mediated skin diseases |
| url | http://dx.doi.org/10.1155/2010/861949 |
| work_keys_str_mv | AT saveriapastore redoximbalanceintcellmediatedskindiseases AT liudmilakorkina redoximbalanceintcellmediatedskindiseases |