<i>Clostridioides difficile</i> Infections and Antibiotherapy: Results of Four Years of Observation in a Romanian Tertiary Hospital
<i>Clostridioides difficile</i> infection (CDI) is one of the main causes of morbidity associated with antibiotic use, producing both healthcare-associated infections and community infections. This study aims to describe the epidemiological characteristics, the clinical outcomes, previou...
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MDPI AG
2024-12-01
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| author | Carmen-Cristina Vasile Luisa-Andreea Gheorghe Carmen-Daniela Chivu Marta Ana Maria Anghel Ștefan Eduard Mîinea Daniela Pițigoi Maria-Dorina Crăciun |
| author_facet | Carmen-Cristina Vasile Luisa-Andreea Gheorghe Carmen-Daniela Chivu Marta Ana Maria Anghel Ștefan Eduard Mîinea Daniela Pițigoi Maria-Dorina Crăciun |
| author_sort | Carmen-Cristina Vasile |
| collection | DOAJ |
| description | <i>Clostridioides difficile</i> infection (CDI) is one of the main causes of morbidity associated with antibiotic use, producing both healthcare-associated infections and community infections. This study aims to describe the epidemiological characteristics, the clinical outcomes, previous antibiotic exposure, and other risk factors of hospitalized patients with CDI in a tertiary infectious disease hospital in Bucharest, Romania. We performed a descriptive analysis based on four-year surveillance data, collected in a tertiary infectious disease hospital in Bucharest, Romania. The annual incidence of CDIs varied from 65.1 cases per 10,000 discharges in 2020 to 211.7 cases per 10,000 discharges in 2023, with a continuously ascending trend. Most of the cases were hospital-acquired cases. There was a high share of antibiotic consumption three months before admission (61.3%). Third-generation cephalosporins, β-lactams with inhibitor combination, and carbapenems were the most used antibiotics, with shares of 46.0%, 25.2%, and 18.6%, respectively. Hospitalization in the previous 12 months and contact with a confirmed CDI case were other frequent factors in the study group, the occurrences of which were recorded as 66.2% and 2.4%, respectively. The surveillance data identified that the annual trend in CDIs is very variable, suggesting the need for continuous and multiannual analysis. |
| format | Article |
| id | doaj-art-d6de9fc9ae124dc8b7310fbdfa7c8b2e |
| institution | Kabale University |
| issn | 2076-2607 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-d6de9fc9ae124dc8b7310fbdfa7c8b2e2024-12-27T14:41:20ZengMDPI AGMicroorganisms2076-26072024-12-011212249010.3390/microorganisms12122490<i>Clostridioides difficile</i> Infections and Antibiotherapy: Results of Four Years of Observation in a Romanian Tertiary HospitalCarmen-Cristina Vasile0Luisa-Andreea Gheorghe1Carmen-Daniela Chivu2Marta Ana Maria Anghel3Ștefan Eduard Mîinea4Daniela Pițigoi5Maria-Dorina Crăciun6Department of Epidemiology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Epidemiology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Epidemiology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Epidemiology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Epidemiology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Epidemiology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Epidemiology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania<i>Clostridioides difficile</i> infection (CDI) is one of the main causes of morbidity associated with antibiotic use, producing both healthcare-associated infections and community infections. This study aims to describe the epidemiological characteristics, the clinical outcomes, previous antibiotic exposure, and other risk factors of hospitalized patients with CDI in a tertiary infectious disease hospital in Bucharest, Romania. We performed a descriptive analysis based on four-year surveillance data, collected in a tertiary infectious disease hospital in Bucharest, Romania. The annual incidence of CDIs varied from 65.1 cases per 10,000 discharges in 2020 to 211.7 cases per 10,000 discharges in 2023, with a continuously ascending trend. Most of the cases were hospital-acquired cases. There was a high share of antibiotic consumption three months before admission (61.3%). Third-generation cephalosporins, β-lactams with inhibitor combination, and carbapenems were the most used antibiotics, with shares of 46.0%, 25.2%, and 18.6%, respectively. Hospitalization in the previous 12 months and contact with a confirmed CDI case were other frequent factors in the study group, the occurrences of which were recorded as 66.2% and 2.4%, respectively. The surveillance data identified that the annual trend in CDIs is very variable, suggesting the need for continuous and multiannual analysis.https://www.mdpi.com/2076-2607/12/12/2490<i>Clostridioides difficile</i>surveillanceincidenceantibiotherapytertiary hospital |
| spellingShingle | Carmen-Cristina Vasile Luisa-Andreea Gheorghe Carmen-Daniela Chivu Marta Ana Maria Anghel Ștefan Eduard Mîinea Daniela Pițigoi Maria-Dorina Crăciun <i>Clostridioides difficile</i> Infections and Antibiotherapy: Results of Four Years of Observation in a Romanian Tertiary Hospital Microorganisms <i>Clostridioides difficile</i> surveillance incidence antibiotherapy tertiary hospital |
| title | <i>Clostridioides difficile</i> Infections and Antibiotherapy: Results of Four Years of Observation in a Romanian Tertiary Hospital |
| title_full | <i>Clostridioides difficile</i> Infections and Antibiotherapy: Results of Four Years of Observation in a Romanian Tertiary Hospital |
| title_fullStr | <i>Clostridioides difficile</i> Infections and Antibiotherapy: Results of Four Years of Observation in a Romanian Tertiary Hospital |
| title_full_unstemmed | <i>Clostridioides difficile</i> Infections and Antibiotherapy: Results of Four Years of Observation in a Romanian Tertiary Hospital |
| title_short | <i>Clostridioides difficile</i> Infections and Antibiotherapy: Results of Four Years of Observation in a Romanian Tertiary Hospital |
| title_sort | i clostridioides difficile i infections and antibiotherapy results of four years of observation in a romanian tertiary hospital |
| topic | <i>Clostridioides difficile</i> surveillance incidence antibiotherapy tertiary hospital |
| url | https://www.mdpi.com/2076-2607/12/12/2490 |
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