Research Progress on the Biosynthesis and Applications of Functional Bile Acids
Bile acid (BA), as an important amphoteric sterol in bile, can regulate glucose and lipid metabolism and homeostasis, intestinal microecology, the intestinal barrier, inflammation, the immune system and the nervous system and other physiological functions through interaction with receptors and the i...
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China Food Publishing Company
2025-01-01
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| Series: | Shipin Kexue |
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| Online Access: | https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-1-029.pdf |
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| author | ZHENG Miao, CHANG Chao, SU Qi, CAI Chenggang, LU Yuyun, ZHAO Minjie, CAI Haiying |
| author_facet | ZHENG Miao, CHANG Chao, SU Qi, CAI Chenggang, LU Yuyun, ZHAO Minjie, CAI Haiying |
| author_sort | ZHENG Miao, CHANG Chao, SU Qi, CAI Chenggang, LU Yuyun, ZHAO Minjie, CAI Haiying |
| collection | DOAJ |
| description | Bile acid (BA), as an important amphoteric sterol in bile, can regulate glucose and lipid metabolism and homeostasis, intestinal microecology, the intestinal barrier, inflammation, the immune system and the nervous system and other physiological functions through interaction with receptors and the intestinal flora, and consequently affect metabolism and nutritional health in the body. In this article, the synthesis pathways of the major new functional BAs are reviewed, and recent progress in research on their functional activity, chemical synthesis and biotransformation is systematically summarized. In addition, this article summarizes the functional studies of selected novel BAs (isodeoxycholic acid, isolithocholic acid (isoLCA), isoallodeoxycholic acid, and isoallolithocholic acid), as well as the microbial sources and catalytic properties of bioconvertases associated with the novel BAs and their potential for application in BA synthesis. Moreover, this article provides an outlook on the application potential of functional BAs in the fields of food and medicine, which provide a reference for the synthesis and transformation of new functional BAs and their comprehensive applications. |
| format | Article |
| id | doaj-art-d6dc0a45722649488947cc1b8839fe5b |
| institution | Kabale University |
| issn | 1002-6630 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | China Food Publishing Company |
| record_format | Article |
| series | Shipin Kexue |
| spelling | doaj-art-d6dc0a45722649488947cc1b8839fe5b2025-02-05T09:08:12ZengChina Food Publishing CompanyShipin Kexue1002-66302025-01-0146125526510.7506/spkx1002-6630-20231204-025Research Progress on the Biosynthesis and Applications of Functional Bile AcidsZHENG Miao, CHANG Chao, SU Qi, CAI Chenggang, LU Yuyun, ZHAO Minjie, CAI Haiying0(1. School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China; 2. Department of Food Science and Engineering, National University of Singapore, Singapore 117542, Singapore; 3. College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China; 4. Mizuda Group Co. Ltd., Huzhou 313002, China)Bile acid (BA), as an important amphoteric sterol in bile, can regulate glucose and lipid metabolism and homeostasis, intestinal microecology, the intestinal barrier, inflammation, the immune system and the nervous system and other physiological functions through interaction with receptors and the intestinal flora, and consequently affect metabolism and nutritional health in the body. In this article, the synthesis pathways of the major new functional BAs are reviewed, and recent progress in research on their functional activity, chemical synthesis and biotransformation is systematically summarized. In addition, this article summarizes the functional studies of selected novel BAs (isodeoxycholic acid, isolithocholic acid (isoLCA), isoallodeoxycholic acid, and isoallolithocholic acid), as well as the microbial sources and catalytic properties of bioconvertases associated with the novel BAs and their potential for application in BA synthesis. Moreover, this article provides an outlook on the application potential of functional BAs in the fields of food and medicine, which provide a reference for the synthesis and transformation of new functional BAs and their comprehensive applications.https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-1-029.pdfbile acids; functionality; biotransformation; hydroxysteroid dehydrogenase; application |
| spellingShingle | ZHENG Miao, CHANG Chao, SU Qi, CAI Chenggang, LU Yuyun, ZHAO Minjie, CAI Haiying Research Progress on the Biosynthesis and Applications of Functional Bile Acids Shipin Kexue bile acids; functionality; biotransformation; hydroxysteroid dehydrogenase; application |
| title | Research Progress on the Biosynthesis and Applications of Functional Bile Acids |
| title_full | Research Progress on the Biosynthesis and Applications of Functional Bile Acids |
| title_fullStr | Research Progress on the Biosynthesis and Applications of Functional Bile Acids |
| title_full_unstemmed | Research Progress on the Biosynthesis and Applications of Functional Bile Acids |
| title_short | Research Progress on the Biosynthesis and Applications of Functional Bile Acids |
| title_sort | research progress on the biosynthesis and applications of functional bile acids |
| topic | bile acids; functionality; biotransformation; hydroxysteroid dehydrogenase; application |
| url | https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-1-029.pdf |
| work_keys_str_mv | AT zhengmiaochangchaosuqicaichenggangluyuyunzhaominjiecaihaiying researchprogressonthebiosynthesisandapplicationsoffunctionalbileacids |