A Transcriptomic Signature of Depressive Symptoms in Late Life

A Transcriptomic Signature of Depressive Symptoms in Late Life

Background: Depressive symptoms in late life can impair daily function and accompany cognitive decline. However, the molecular mechanisms that underlie these changes in the brain remain poorly understood. Methods: Differential expression analysis was performed on bulk-tissue RNA sequencing data gene...

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Bibliographic Details
Main Authors: Stuart Matan-Lithwick, Melissa C. Misztal, Mu Yang, Thomas DeLong, Shreejoy Tripathy, Jeffrey T. Dunn, David A. Bennett, Philip L. De Jager, Yanling Wang, Daniel W. Fisher, Hongxin Dong, Daniel Felsky
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Biological Psychiatry Global Open Science
Subjects:
Aging
Depression
Differential expression
Genetics
Postmortem brain
RNA-seq
Online Access:http://www.sciencedirect.com/science/article/pii/S2667174325000023
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