The Melanocortin System in Control of Inflammation
Melanocortin peptides, the collective term for α-, β-, and γ-melanocyte-stimulating hormone (α-, β-, γ-MSH) and adrenocorticotropic hormone (ACTH), are elements of an ancient modulatory system. Natural melanocortins derive from the common precursor pro-opiomelanocortin (POMC). Five receptor subtypes...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.173 |
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| author | Anna Catania Caterina Lonati Andrea Sordi Andrea Carlin Patrizia Leonardi Stefano Gatti |
| author_facet | Anna Catania Caterina Lonati Andrea Sordi Andrea Carlin Patrizia Leonardi Stefano Gatti |
| author_sort | Anna Catania |
| collection | DOAJ |
| description | Melanocortin peptides, the collective term for α-, β-, and γ-melanocyte-stimulating hormone (α-, β-, γ-MSH) and adrenocorticotropic hormone (ACTH), are elements of an ancient modulatory system. Natural melanocortins derive from the common precursor pro-opiomelanocortin (POMC). Five receptor subtypes for melanocortins (MC1-MC5) are widely distributed in brain regions and in peripheral cells. Melanocortin receptor activation by natural or synthetic ligands exerts marked anti-inflammatory and immunomodulatory effects. The anticytokine action and the inhibitory influences on inflammatory cell migration make melanocortins potential new drugs for treatment of inflammatory disorders. Effectiveness in treatment of acute, chronic, and systemic inflammatory disorders is well documented in preclinical studies. Further, melanocortins are promising compounds in neuroprotection. This review examines the main signaling circuits in anti-inflammatory and immunomodulatory actions of melanocortins, and the potential therapeutic use of these molecules. |
| format | Article |
| id | doaj-art-d6dbc745f22f40889d612e1c472ba2f5 |
| institution | DOAJ |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-d6dbc745f22f40889d612e1c472ba2f52025-08-20T03:19:49ZengWileyThe Scientific World Journal1537-744X2010-01-01101840185310.1100/tsw.2010.173The Melanocortin System in Control of InflammationAnna Catania0Caterina Lonati1Andrea Sordi2Andrea Carlin3Patrizia Leonardi4Stefano Gatti5Center for Preclinical Investigation, Ospedale Maggiore Policlinico, Milano, ItalyCenter for Preclinical Investigation, Ospedale Maggiore Policlinico, Milano, ItalyCenter for Preclinical Investigation, Ospedale Maggiore Policlinico, Milano, ItalyCenter for Preclinical Investigation, Ospedale Maggiore Policlinico, Milano, ItalyCenter for Preclinical Investigation, Ospedale Maggiore Policlinico, Milano, ItalyCenter for Surgical Research, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milano, ItalyMelanocortin peptides, the collective term for α-, β-, and γ-melanocyte-stimulating hormone (α-, β-, γ-MSH) and adrenocorticotropic hormone (ACTH), are elements of an ancient modulatory system. Natural melanocortins derive from the common precursor pro-opiomelanocortin (POMC). Five receptor subtypes for melanocortins (MC1-MC5) are widely distributed in brain regions and in peripheral cells. Melanocortin receptor activation by natural or synthetic ligands exerts marked anti-inflammatory and immunomodulatory effects. The anticytokine action and the inhibitory influences on inflammatory cell migration make melanocortins potential new drugs for treatment of inflammatory disorders. Effectiveness in treatment of acute, chronic, and systemic inflammatory disorders is well documented in preclinical studies. Further, melanocortins are promising compounds in neuroprotection. This review examines the main signaling circuits in anti-inflammatory and immunomodulatory actions of melanocortins, and the potential therapeutic use of these molecules.http://dx.doi.org/10.1100/tsw.2010.173 |
| spellingShingle | Anna Catania Caterina Lonati Andrea Sordi Andrea Carlin Patrizia Leonardi Stefano Gatti The Melanocortin System in Control of Inflammation The Scientific World Journal |
| title | The Melanocortin System in Control of Inflammation |
| title_full | The Melanocortin System in Control of Inflammation |
| title_fullStr | The Melanocortin System in Control of Inflammation |
| title_full_unstemmed | The Melanocortin System in Control of Inflammation |
| title_short | The Melanocortin System in Control of Inflammation |
| title_sort | melanocortin system in control of inflammation |
| url | http://dx.doi.org/10.1100/tsw.2010.173 |
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