A successful combination of upadacitinib and guselkumab in refractory psoriasis and psoriatic arthritis: A case report
Monotherapy may not be sufficient for the complete control of the psoriatic disease in selected patients. In refractory patients, combining two drugs with different mechanisms of action may result in improved efficacy. Data regarding the combination of biologics and Janus kinase inhibitors are lacki...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-06-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X251352160 |
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| author | Sofia Antolini Giorgia Scagliosi Olta Veliaj Antonio Carletto Elena Fracassi Paolo Gisondi |
| author_facet | Sofia Antolini Giorgia Scagliosi Olta Veliaj Antonio Carletto Elena Fracassi Paolo Gisondi |
| author_sort | Sofia Antolini |
| collection | DOAJ |
| description | Monotherapy may not be sufficient for the complete control of the psoriatic disease in selected patients. In refractory patients, combining two drugs with different mechanisms of action may result in improved efficacy. Data regarding the combination of biologics and Janus kinase inhibitors are lacking. A 61-year-old man affected by severe chronic plaque psoriasis and peripheral psoriatic arthritis affecting hands and feet, dactylitis, and enthesitis was successfully treated with a combination of upadacitinib and guselkumab. The combination of the two drugs was needed because upadacitinib was effective on psoriatic arthritis, but not on the skin lesions, while responding to guselkumab, which, vice versa, was not effective on psoriatic arthritis. Notably, the patients failed different conventional synthetic and biologic drugs. At a follow-up of 12 months, he had not experienced adverse events or laboratory alterations. Other studies are necessary to confirm the efficacy and safety profile of upadacitinib associated with guselkumab. |
| format | Article |
| id | doaj-art-d6dad8ec75aa4153aa511b91ea38ec1a |
| institution | Kabale University |
| issn | 2050-313X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj-art-d6dad8ec75aa4153aa511b91ea38ec1a2025-08-20T03:28:37ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2025-06-011310.1177/2050313X251352160A successful combination of upadacitinib and guselkumab in refractory psoriasis and psoriatic arthritis: A case reportSofia Antolini0Giorgia Scagliosi1Olta Veliaj2Antonio Carletto3Elena Fracassi4Paolo Gisondi5Section of Rheumatology, Department of Medicine, University of Verona, ItalySection of Rheumatology, Department of Medicine, University of Verona, ItalySection of Rheumatology, Department of Medicine, University of Verona, ItalySection of Rheumatology, Department of Medicine, University of Verona, ItalySection of Rheumatology, Department of Medicine, University of Verona, ItalySection of Dermatology and Venereology, Department of Medicine, University of Verona, ItalyMonotherapy may not be sufficient for the complete control of the psoriatic disease in selected patients. In refractory patients, combining two drugs with different mechanisms of action may result in improved efficacy. Data regarding the combination of biologics and Janus kinase inhibitors are lacking. A 61-year-old man affected by severe chronic plaque psoriasis and peripheral psoriatic arthritis affecting hands and feet, dactylitis, and enthesitis was successfully treated with a combination of upadacitinib and guselkumab. The combination of the two drugs was needed because upadacitinib was effective on psoriatic arthritis, but not on the skin lesions, while responding to guselkumab, which, vice versa, was not effective on psoriatic arthritis. Notably, the patients failed different conventional synthetic and biologic drugs. At a follow-up of 12 months, he had not experienced adverse events or laboratory alterations. Other studies are necessary to confirm the efficacy and safety profile of upadacitinib associated with guselkumab.https://doi.org/10.1177/2050313X251352160 |
| spellingShingle | Sofia Antolini Giorgia Scagliosi Olta Veliaj Antonio Carletto Elena Fracassi Paolo Gisondi A successful combination of upadacitinib and guselkumab in refractory psoriasis and psoriatic arthritis: A case report SAGE Open Medical Case Reports |
| title | A successful combination of upadacitinib and guselkumab in refractory psoriasis and psoriatic arthritis: A case report |
| title_full | A successful combination of upadacitinib and guselkumab in refractory psoriasis and psoriatic arthritis: A case report |
| title_fullStr | A successful combination of upadacitinib and guselkumab in refractory psoriasis and psoriatic arthritis: A case report |
| title_full_unstemmed | A successful combination of upadacitinib and guselkumab in refractory psoriasis and psoriatic arthritis: A case report |
| title_short | A successful combination of upadacitinib and guselkumab in refractory psoriasis and psoriatic arthritis: A case report |
| title_sort | successful combination of upadacitinib and guselkumab in refractory psoriasis and psoriatic arthritis a case report |
| url | https://doi.org/10.1177/2050313X251352160 |
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