The 2023 Bethesda System for Reporting Thyroid Cytopathology: A review update

The Bethesda System for Reporting Thyroid Cytopathology is the first reporting system in non-gynaecologic cytopathology after the Bethesda system for Reporting Cervical Cytopathology. It provides a uniform reporting system for pathologists and clinicians in thyroid cytology. The system has six diagn...

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Main Authors: A. Parmar Riddhi, Patel Keval
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-10-01
Series:Journal of Clinical and Scientific Research
Subjects:
Online Access:https://journals.lww.com/10.4103/jcsr.jcsr_212_23
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author A. Parmar Riddhi
Patel Keval
author_facet A. Parmar Riddhi
Patel Keval
author_sort A. Parmar Riddhi
collection DOAJ
description The Bethesda System for Reporting Thyroid Cytopathology is the first reporting system in non-gynaecologic cytopathology after the Bethesda system for Reporting Cervical Cytopathology. It provides a uniform reporting system for pathologists and clinicians in thyroid cytology. The system has six diagnostic categories with defined criteria, risk of malignancy (ROM) and management recommendations. It underwent two revisions in 2010 and 2017, and a third edition was published in 2023. This review summarises the system, including potential pitfalls and molecular testing. Each category has an updated ROM and an average with a range of cancer risk. The atypia of undetermined significance sub-categorisation is simplified into two groups based on ROM and molecular profiling. Paediatric thyroid disease and its ROM along with management algorithms are discussed. The nomenclature aligns with the 2022 World Health Organization Classification of Thyroid Neoplasms. Two new chapters cover the use of molecular, ancillary testing in thyroid cytopathology with clinical perspectives and imaging findings in thyroid disease.
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spelling doaj-art-d6d7fa2e025745339ea4b202c557c35c2025-08-20T02:09:40ZengWolters Kluwer Medknow PublicationsJournal of Clinical and Scientific Research2277-57062277-83572024-10-0113429730710.4103/jcsr.jcsr_212_23The 2023 Bethesda System for Reporting Thyroid Cytopathology: A review updateA. Parmar RiddhiPatel KevalThe Bethesda System for Reporting Thyroid Cytopathology is the first reporting system in non-gynaecologic cytopathology after the Bethesda system for Reporting Cervical Cytopathology. It provides a uniform reporting system for pathologists and clinicians in thyroid cytology. The system has six diagnostic categories with defined criteria, risk of malignancy (ROM) and management recommendations. It underwent two revisions in 2010 and 2017, and a third edition was published in 2023. This review summarises the system, including potential pitfalls and molecular testing. Each category has an updated ROM and an average with a range of cancer risk. The atypia of undetermined significance sub-categorisation is simplified into two groups based on ROM and molecular profiling. Paediatric thyroid disease and its ROM along with management algorithms are discussed. The nomenclature aligns with the 2022 World Health Organization Classification of Thyroid Neoplasms. Two new chapters cover the use of molecular, ancillary testing in thyroid cytopathology with clinical perspectives and imaging findings in thyroid disease.https://journals.lww.com/10.4103/jcsr.jcsr_212_23bethesdacancercytopathologythyroid
spellingShingle A. Parmar Riddhi
Patel Keval
The 2023 Bethesda System for Reporting Thyroid Cytopathology: A review update
Journal of Clinical and Scientific Research
bethesda
cancer
cytopathology
thyroid
title The 2023 Bethesda System for Reporting Thyroid Cytopathology: A review update
title_full The 2023 Bethesda System for Reporting Thyroid Cytopathology: A review update
title_fullStr The 2023 Bethesda System for Reporting Thyroid Cytopathology: A review update
title_full_unstemmed The 2023 Bethesda System for Reporting Thyroid Cytopathology: A review update
title_short The 2023 Bethesda System for Reporting Thyroid Cytopathology: A review update
title_sort 2023 bethesda system for reporting thyroid cytopathology a review update
topic bethesda
cancer
cytopathology
thyroid
url https://journals.lww.com/10.4103/jcsr.jcsr_212_23
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