Small GTPase Rab3B: biological properties and possible role in carcinogenesis
Proteins of the superfamily of small guanosine triphosphate hydrolase (GTPase) perform various functions: from the control of cell proliferation to the regulation of vesicular transport. The superfamily of small GTPase Ras includes more than 150 proteins, devided to 5 major families (Arf, Ran, Rho,...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2019-01-01
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| Series: | Успехи молекулярной онкологии |
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| Online Access: | https://umo.abvpress.ru/jour/article/view/176 |
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| author | A. A. Budko P. A. Khesina L. M. Diakov N. L. Lazarevich |
| author_facet | A. A. Budko P. A. Khesina L. M. Diakov N. L. Lazarevich |
| author_sort | A. A. Budko |
| collection | DOAJ |
| description | Proteins of the superfamily of small guanosine triphosphate hydrolase (GTPase) perform various functions: from the control of cell proliferation to the regulation of vesicular transport. The superfamily of small GTPase Ras includes more than 150 proteins, devided to 5 major families (Arf, Ran, Rho, Ras and Rab), and plays an important role in carcinogenesis. Compared to the other families, the Rab family was investigated by relatively small number studies, which does not equally reflect their role in malignant transformation processes. In our review we have focused on both the subfamily Rab3 and its poorly investigated member Rab3B. Recent findings allow to consider Rab3B not only as a promising diagnostic or prognostic marker for several types of neoplasms, but also is a potential target for antitumor therapy. Our analysis of publicly available transcriptional databases revealed that kidney, lung and liver cancer patients with low Rab3B gene expression demonstrate a better overall five-year survival. |
| format | Article |
| id | doaj-art-d6d5a5ae7d9a4ccb86efb07892132d40 |
| institution | Kabale University |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj-art-d6d5a5ae7d9a4ccb86efb07892132d402025-08-20T04:00:14ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872019-01-0154788510.17650/2313-805X-2018-5-4-78-85140Small GTPase Rab3B: biological properties and possible role in carcinogenesisA. A. Budko0P. A. Khesina1L. M. Diakov2N. L. Lazarevich3Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; M.V. Lomonosov Moscow State UniversityResearch Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; M.V. Lomonosov Moscow State UniversityResearch Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaResearch Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; M.V. Lomonosov Moscow State UniversityProteins of the superfamily of small guanosine triphosphate hydrolase (GTPase) perform various functions: from the control of cell proliferation to the regulation of vesicular transport. The superfamily of small GTPase Ras includes more than 150 proteins, devided to 5 major families (Arf, Ran, Rho, Ras and Rab), and plays an important role in carcinogenesis. Compared to the other families, the Rab family was investigated by relatively small number studies, which does not equally reflect their role in malignant transformation processes. In our review we have focused on both the subfamily Rab3 and its poorly investigated member Rab3B. Recent findings allow to consider Rab3B not only as a promising diagnostic or prognostic marker for several types of neoplasms, but also is a potential target for antitumor therapy. Our analysis of publicly available transcriptional databases revealed that kidney, lung and liver cancer patients with low Rab3B gene expression demonstrate a better overall five-year survival.https://umo.abvpress.ru/jour/article/view/176gtpaserab family proteinstumor markerrab3b proteincarcinogenesisoverall survival |
| spellingShingle | A. A. Budko P. A. Khesina L. M. Diakov N. L. Lazarevich Small GTPase Rab3B: biological properties and possible role in carcinogenesis Успехи молекулярной онкологии gtpase rab family proteins tumor marker rab3b protein carcinogenesis overall survival |
| title | Small GTPase Rab3B: biological properties and possible role in carcinogenesis |
| title_full | Small GTPase Rab3B: biological properties and possible role in carcinogenesis |
| title_fullStr | Small GTPase Rab3B: biological properties and possible role in carcinogenesis |
| title_full_unstemmed | Small GTPase Rab3B: biological properties and possible role in carcinogenesis |
| title_short | Small GTPase Rab3B: biological properties and possible role in carcinogenesis |
| title_sort | small gtpase rab3b biological properties and possible role in carcinogenesis |
| topic | gtpase rab family proteins tumor marker rab3b protein carcinogenesis overall survival |
| url | https://umo.abvpress.ru/jour/article/view/176 |
| work_keys_str_mv | AT aabudko smallgtpaserab3bbiologicalpropertiesandpossibleroleincarcinogenesis AT pakhesina smallgtpaserab3bbiologicalpropertiesandpossibleroleincarcinogenesis AT lmdiakov smallgtpaserab3bbiologicalpropertiesandpossibleroleincarcinogenesis AT nllazarevich smallgtpaserab3bbiologicalpropertiesandpossibleroleincarcinogenesis |