The comprehensive assessment of epigenetics changes during skin development
Epigenetic regulation is critical to multiple physiological and pathological processes. However, little is known regarding the epigenetic changes during neonatal skin development and skin aging, and in response to ultraviolet (UV) exposure. The transcriptomes of human skin samples from different age...
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KeAi Communications Co. Ltd.
2025-01-01
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| Series: | Fundamental Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266732582200365X |
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| author | Li Lei Ling Jiang Yibo Hu Menglu Chen Jinhua Huang Jing Chen Qinghai Zeng |
| author_facet | Li Lei Ling Jiang Yibo Hu Menglu Chen Jinhua Huang Jing Chen Qinghai Zeng |
| author_sort | Li Lei |
| collection | DOAJ |
| description | Epigenetic regulation is critical to multiple physiological and pathological processes. However, little is known regarding the epigenetic changes during neonatal skin development and skin aging, and in response to ultraviolet (UV) exposure. The transcriptomes of human skin samples from different ages or irradiated with different types and doses of UV light were analyzed using R (version 4.0.3) software. The epigenetic landscape of the skin, including histone modifications, genetic imprinting and m6A modification, which are mainly involved in collagen formation, extracellular matrix organization, immune function and keratinization, underwent significant changes during neonatal to adult development. Epigenetic effectors such as IGF2BP2, GATA2, GATA3, CPA4 and CDK1 were significantly correlated with extracellular matrix organization, and VEGFA, CDK1 and PRKCB with skin immune function. The m6A readers such as IGF2BP2, IGF2BP3, HNRNPA2B1 and EIF3G showed significant correlation with extracellular matrix organization, metabolism, or antigen processing and presentation. Small doses of UV exposure only induced changes in the expression levels of some epigenetic effectors, without any significant effect on the overall epigenetic landscape. However, the minimal erythema dose of UV exposure altered multiple epigenetic effectors regulating extracellular matrix organization, cell-matrix adhesion, innate immune response, mitochondrial function and mRNA processing. In addition, epigenetic changes following UV exposure were more pronounced in the elderly skin compared to the younger skin. In conclusion, histone modifications, genetic imprinting and m6A modification play critical roles during skin development, and a large dose of UV exposure can significantly change the expression of multiple epigenetic effectors. |
| format | Article |
| id | doaj-art-d6d5884c2a0e4f3d8e39f8c2eda02c3e |
| institution | Kabale University |
| issn | 2667-3258 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co. Ltd. |
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| series | Fundamental Research |
| spelling | doaj-art-d6d5884c2a0e4f3d8e39f8c2eda02c3e2025-01-29T05:02:27ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582025-01-0151228240The comprehensive assessment of epigenetics changes during skin developmentLi Lei0Ling Jiang1Yibo Hu2Menglu Chen3Jinhua Huang4Jing Chen5Qinghai Zeng6Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, ChinaDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, ChinaDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, ChinaDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, ChinaDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, ChinaDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, ChinaCorresponding author.; Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, ChinaEpigenetic regulation is critical to multiple physiological and pathological processes. However, little is known regarding the epigenetic changes during neonatal skin development and skin aging, and in response to ultraviolet (UV) exposure. The transcriptomes of human skin samples from different ages or irradiated with different types and doses of UV light were analyzed using R (version 4.0.3) software. The epigenetic landscape of the skin, including histone modifications, genetic imprinting and m6A modification, which are mainly involved in collagen formation, extracellular matrix organization, immune function and keratinization, underwent significant changes during neonatal to adult development. Epigenetic effectors such as IGF2BP2, GATA2, GATA3, CPA4 and CDK1 were significantly correlated with extracellular matrix organization, and VEGFA, CDK1 and PRKCB with skin immune function. The m6A readers such as IGF2BP2, IGF2BP3, HNRNPA2B1 and EIF3G showed significant correlation with extracellular matrix organization, metabolism, or antigen processing and presentation. Small doses of UV exposure only induced changes in the expression levels of some epigenetic effectors, without any significant effect on the overall epigenetic landscape. However, the minimal erythema dose of UV exposure altered multiple epigenetic effectors regulating extracellular matrix organization, cell-matrix adhesion, innate immune response, mitochondrial function and mRNA processing. In addition, epigenetic changes following UV exposure were more pronounced in the elderly skin compared to the younger skin. In conclusion, histone modifications, genetic imprinting and m6A modification play critical roles during skin development, and a large dose of UV exposure can significantly change the expression of multiple epigenetic effectors.http://www.sciencedirect.com/science/article/pii/S266732582200365XEpigeneticsSkin developmentAgingUltravioletm6A |
| spellingShingle | Li Lei Ling Jiang Yibo Hu Menglu Chen Jinhua Huang Jing Chen Qinghai Zeng The comprehensive assessment of epigenetics changes during skin development Fundamental Research Epigenetics Skin development Aging Ultraviolet m6A |
| title | The comprehensive assessment of epigenetics changes during skin development |
| title_full | The comprehensive assessment of epigenetics changes during skin development |
| title_fullStr | The comprehensive assessment of epigenetics changes during skin development |
| title_full_unstemmed | The comprehensive assessment of epigenetics changes during skin development |
| title_short | The comprehensive assessment of epigenetics changes during skin development |
| title_sort | comprehensive assessment of epigenetics changes during skin development |
| topic | Epigenetics Skin development Aging Ultraviolet m6A |
| url | http://www.sciencedirect.com/science/article/pii/S266732582200365X |
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