Acute promyelocytic leukemia lacking t(15;17): Molecular evidence of atypical PML/RAR-α transcriptional variant by gene sequencing

Acute promyelocytic leukemia lacking t(15;17): Molecular evidence of atypical PML/RAR-α transcriptional variant by gene sequencing

Introduction. The accurate diagnosis of acute promyelocytic leukemia (APL), not only on the morphological and clinical, but also on the molecular level, is very important for application of targeted therapies. Case report. A 62- year-old woman presented with APL. By using conventional cytogenetic an...

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Main Authors: Đorđević Vesna, Tošić Nataša, Denčić-Fekete Marija, Virijević Marijana, Jovanović Jelica, Jaković Ljubomir, Kraguljac-Kurtović Nada, Bogdanović Andrija, Kostić Tatjana, Pavlović Sonja
Format: Article
Language:English
Published: Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade 2020-01-01
Series:Vojnosanitetski Pregled
Subjects:
diagnosis
in situ hibridization, fluorescence
leukemia, promyelocytic, acute
molecular biology
reverse transcriptase polymerase chain reaction
Online Access:http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84501800040D.pdf
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