Diabetic polyneuropathy: pathogenesis, classification, clinical presentation, and treatment
Diabetes mellitus (DM) is a global epidemic followed by late complications as diabetic polyneuropathy (DPN) and diabetic foot syndrome, leading to appreciable social and economic consequences. Virtually all patients with DM develop DPN in different periods. There is a clear correlation between the p...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IMA-PRESS LLC
2013-11-01
|
| Series: | Неврология, нейропсихиатрия, психосоматика |
| Subjects: | |
| Online Access: | https://nnp.ima-press.net/nnp/article/view/201 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850188120633376768 |
|---|---|
| author | Marina Valentinovna Nesterova V V Galkin |
| author_facet | Marina Valentinovna Nesterova V V Galkin |
| author_sort | Marina Valentinovna Nesterova |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a global epidemic followed by late complications as diabetic polyneuropathy (DPN) and diabetic foot syndrome, leading to appreciable social and economic consequences. Virtually all patients with DM develop DPN in different periods. There is a clear correlation between the presence and magnitude of painful DPN and the duration of DM and the level of glycosylated hemoglobin and the severity of DPN. In spite of the abundance of theories of the development of DPN, its main identified pathogenetic factor is hyperglycemia. The literature gives no universal classification due to the variability of clinical symptoms. The main goals of treatment are to affect the pathogenesis of the disease and to prescribe symptomatic medications. The pathogenetic treatment of DPN includes compensation for carbohydrate metabolism and use of neurometabolic drugs. Pain from DPN may be controlled with antidepressants, anticonvulsants, local anesthetics and opioid analgesics. Although much evidence for the pathogenesis of peripheral nervous system injury has been recently accumulated, a universal standard for the effective therapy of DPN and the follow-up of these patients has not yet been developed. |
| format | Article |
| id | doaj-art-d6d0227d69264e61bd4bbf9cd1ff605d |
| institution | OA Journals |
| issn | 2074-2711 2310-1342 |
| language | Russian |
| publishDate | 2013-11-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Неврология, нейропсихиатрия, психосоматика |
| spelling | doaj-art-d6d0227d69264e61bd4bbf9cd1ff605d2025-08-20T02:15:58ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422013-11-01529710510.14412/2074-2711-2013-2422201Diabetic polyneuropathy: pathogenesis, classification, clinical presentation, and treatmentMarina Valentinovna NesterovaV V GalkinDiabetes mellitus (DM) is a global epidemic followed by late complications as diabetic polyneuropathy (DPN) and diabetic foot syndrome, leading to appreciable social and economic consequences. Virtually all patients with DM develop DPN in different periods. There is a clear correlation between the presence and magnitude of painful DPN and the duration of DM and the level of glycosylated hemoglobin and the severity of DPN. In spite of the abundance of theories of the development of DPN, its main identified pathogenetic factor is hyperglycemia. The literature gives no universal classification due to the variability of clinical symptoms. The main goals of treatment are to affect the pathogenesis of the disease and to prescribe symptomatic medications. The pathogenetic treatment of DPN includes compensation for carbohydrate metabolism and use of neurometabolic drugs. Pain from DPN may be controlled with antidepressants, anticonvulsants, local anesthetics and opioid analgesics. Although much evidence for the pathogenesis of peripheral nervous system injury has been recently accumulated, a universal standard for the effective therapy of DPN and the follow-up of these patients has not yet been developed.https://nnp.ima-press.net/nnp/article/view/201diabetes mellitusdiabetic polyneuropathypainful syndrome |
| spellingShingle | Marina Valentinovna Nesterova V V Galkin Diabetic polyneuropathy: pathogenesis, classification, clinical presentation, and treatment Неврология, нейропсихиатрия, психосоматика diabetes mellitus diabetic polyneuropathy painful syndrome |
| title | Diabetic polyneuropathy: pathogenesis, classification, clinical presentation, and treatment |
| title_full | Diabetic polyneuropathy: pathogenesis, classification, clinical presentation, and treatment |
| title_fullStr | Diabetic polyneuropathy: pathogenesis, classification, clinical presentation, and treatment |
| title_full_unstemmed | Diabetic polyneuropathy: pathogenesis, classification, clinical presentation, and treatment |
| title_short | Diabetic polyneuropathy: pathogenesis, classification, clinical presentation, and treatment |
| title_sort | diabetic polyneuropathy pathogenesis classification clinical presentation and treatment |
| topic | diabetes mellitus diabetic polyneuropathy painful syndrome |
| url | https://nnp.ima-press.net/nnp/article/view/201 |
| work_keys_str_mv | AT marinavalentinovnanesterova diabeticpolyneuropathypathogenesisclassificationclinicalpresentationandtreatment AT vvgalkin diabeticpolyneuropathypathogenesisclassificationclinicalpresentationandtreatment |