Circulating Th1 and Th2 cytokines in patients with hepatitis C virus infection
The imbalance of T-helper (Th) lymphocyte cytokine production may play an important role in immunopathogenes is of persistent hepatitis C virus (HCV) infection. To know whether an imbalance between Th1 and Th2 cytokines is present in chronic HCV infection, serum levels of Th1 cytokines , interferon...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1998-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629359890992 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849695379903217664 |
|---|---|
| author | X. G. Fan W. E. Liu C. Z. Li Z. C. Wang L. X. Luo D. M. Tan G. L. Hu Z. Zhang |
| author_facet | X. G. Fan W. E. Liu C. Z. Li Z. C. Wang L. X. Luo D. M. Tan G. L. Hu Z. Zhang |
| author_sort | X. G. Fan |
| collection | DOAJ |
| description | The imbalance of T-helper (Th) lymphocyte cytokine production may play an important role in immunopathogenes is of persistent hepatitis C virus (HCV) infection. To know whether an imbalance between Th1 and Th2 cytokines is present in chronic HCV infection, serum levels of Th1 cytokines , interferon gamma (IFN-γ ) and interleukin (IL)-2, and Th2 cytokines, IL-4 and IL-10, were measured using enzyme - linked immunosorbent as say in this study. Eighteen individuals with chronic HCV infection, 11 healthy subjects as normal controls and 10 chronic HBV infected patients as disease controls were observed. The results showed that the leve ls of Th2 cytokines (IL-4 and IL-10) were significantly increased inchronic HCV infected patients compared with normal controls (IL-4: 30.49 ± 17.55 vs . 14.94 ± 13.73, pg/ml, p<0.025; IL-10: 50.30 ± 19.59 vs. 17.87 ± 9.49, pg/ml, p<0.001). Similarly, the levels of Th1 cytokine, IL-2, was also elevated in individuals with chronic HCV infection when compared with normal controls (IL-2: 118.53 ± 95.23 vs . 61.57 ± 28.70, pg/ml, p<0.05). However, Th1 cytokine IFN-γ level was not significantly changed during HCV infection (IFN-γ: 28.09 ± 15.65 vs . 24.10 ± 15.61, pg/ml, p>0.05). Further more, the elevated levels of Th2 cytokines are greater than Th1 cytokines in HCV infection. Thus , the study indicates that an enhanced Th2 responses are present during chronic HCV infection, which may partly be
responsible for the persistence of HCV infection. |
| format | Article |
| id | doaj-art-d6cea8e395cb418ea950d2294cb70fb6 |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d6cea8e395cb418ea950d2294cb70fb62025-08-20T03:19:47ZengWileyMediators of Inflammation0962-93511466-18611998-01-017429529710.1080/09629359890992Circulating Th1 and Th2 cytokines in patients with hepatitis C virus infectionX. G. Fan0W. E. Liu1C. Z. Li2Z. C. Wang3L. X. Luo4D. M. Tan5G. L. Hu6Z. Zhang7Department of Infectious Diseases, Xiangya Hospital, Hunan Medical University, Hunan, Changsha, ChinaDepartment of Infectious Diseases, Xiangya Hospital, Hunan Medical University, Hunan, Changsha, ChinaDepartment of Infectious Diseases, Xiangya Hospital, Hunan Medical University, Hunan, Changsha, ChinaDepartment of Blood Transfusion, Xiangya Hospital, Hunan Medical University, Hunan, Changsha, ChinaDepartment of Infectious Diseases, Xiangya Hospital, Hunan Medical University, Hunan, Changsha, ChinaDepartment of Infectious Diseases, Xiangya Hospital, Hunan Medical University, Hunan, Changsha, ChinaDepartment of Infectious Diseases, Xiangya Hospital, Hunan Medical University, Hunan, Changsha, ChinaDepartment of Infectious Diseases, Xiangya Hospital, Hunan Medical University, Hunan, Changsha, ChinaThe imbalance of T-helper (Th) lymphocyte cytokine production may play an important role in immunopathogenes is of persistent hepatitis C virus (HCV) infection. To know whether an imbalance between Th1 and Th2 cytokines is present in chronic HCV infection, serum levels of Th1 cytokines , interferon gamma (IFN-γ ) and interleukin (IL)-2, and Th2 cytokines, IL-4 and IL-10, were measured using enzyme - linked immunosorbent as say in this study. Eighteen individuals with chronic HCV infection, 11 healthy subjects as normal controls and 10 chronic HBV infected patients as disease controls were observed. The results showed that the leve ls of Th2 cytokines (IL-4 and IL-10) were significantly increased inchronic HCV infected patients compared with normal controls (IL-4: 30.49 ± 17.55 vs . 14.94 ± 13.73, pg/ml, p<0.025; IL-10: 50.30 ± 19.59 vs. 17.87 ± 9.49, pg/ml, p<0.001). Similarly, the levels of Th1 cytokine, IL-2, was also elevated in individuals with chronic HCV infection when compared with normal controls (IL-2: 118.53 ± 95.23 vs . 61.57 ± 28.70, pg/ml, p<0.05). However, Th1 cytokine IFN-γ level was not significantly changed during HCV infection (IFN-γ: 28.09 ± 15.65 vs . 24.10 ± 15.61, pg/ml, p>0.05). Further more, the elevated levels of Th2 cytokines are greater than Th1 cytokines in HCV infection. Thus , the study indicates that an enhanced Th2 responses are present during chronic HCV infection, which may partly be responsible for the persistence of HCV infection.http://dx.doi.org/10.1080/09629359890992 |
| spellingShingle | X. G. Fan W. E. Liu C. Z. Li Z. C. Wang L. X. Luo D. M. Tan G. L. Hu Z. Zhang Circulating Th1 and Th2 cytokines in patients with hepatitis C virus infection Mediators of Inflammation |
| title | Circulating Th1 and Th2 cytokines in patients with hepatitis C virus infection |
| title_full | Circulating Th1 and Th2 cytokines in patients with hepatitis C virus infection |
| title_fullStr | Circulating Th1 and Th2 cytokines in patients with hepatitis C virus infection |
| title_full_unstemmed | Circulating Th1 and Th2 cytokines in patients with hepatitis C virus infection |
| title_short | Circulating Th1 and Th2 cytokines in patients with hepatitis C virus infection |
| title_sort | circulating th1 and th2 cytokines in patients with hepatitis c virus infection |
| url | http://dx.doi.org/10.1080/09629359890992 |
| work_keys_str_mv | AT xgfan circulatingth1andth2cytokinesinpatientswithhepatitiscvirusinfection AT weliu circulatingth1andth2cytokinesinpatientswithhepatitiscvirusinfection AT czli circulatingth1andth2cytokinesinpatientswithhepatitiscvirusinfection AT zcwang circulatingth1andth2cytokinesinpatientswithhepatitiscvirusinfection AT lxluo circulatingth1andth2cytokinesinpatientswithhepatitiscvirusinfection AT dmtan circulatingth1andth2cytokinesinpatientswithhepatitiscvirusinfection AT glhu circulatingth1andth2cytokinesinpatientswithhepatitiscvirusinfection AT zzhang circulatingth1andth2cytokinesinpatientswithhepatitiscvirusinfection |