Cancer Microenvironment and Endoplasmic Reticulum Stress Response
Different stressful conditions such as hypoxia, nutrient deprivation, pH changes, or reduced vascularization, potentially able to act as growth-limiting factors for tumor cells, activate the unfolded protein response (UPR). UPR is therefore involved in tumor growth and adaptation to severe environme...
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Format: | Article |
Language: | English |
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Wiley
2015-01-01
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Series: | Mediators of Inflammation |
Online Access: | http://dx.doi.org/10.1155/2015/417281 |
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author | Claudia Giampietri Simonetta Petrungaro Silvia Conti Antonio Facchiano Antonio Filippini Elio Ziparo |
author_facet | Claudia Giampietri Simonetta Petrungaro Silvia Conti Antonio Facchiano Antonio Filippini Elio Ziparo |
author_sort | Claudia Giampietri |
collection | DOAJ |
description | Different stressful conditions such as hypoxia, nutrient deprivation, pH changes, or reduced vascularization, potentially able to act as growth-limiting factors for tumor cells, activate the unfolded protein response (UPR). UPR is therefore involved in tumor growth and adaptation to severe environments and is generally cytoprotective in cancer. The present review describes the molecular mechanisms underlying UPR and able to promote survival and proliferation in cancer. The critical role of UPR activation in tumor growth promotion is discussed in detail for a few paradigmatic tumors such as prostate cancer and melanoma. |
format | Article |
id | doaj-art-d6ce7e930cb140548fbfb6b2b37c9a99 |
institution | Kabale University |
issn | 0962-9351 1466-1861 |
language | English |
publishDate | 2015-01-01 |
publisher | Wiley |
record_format | Article |
series | Mediators of Inflammation |
spelling | doaj-art-d6ce7e930cb140548fbfb6b2b37c9a992025-02-03T00:59:34ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/417281417281Cancer Microenvironment and Endoplasmic Reticulum Stress ResponseClaudia Giampietri0Simonetta Petrungaro1Silvia Conti2Antonio Facchiano3Antonio Filippini4Elio Ziparo5Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Histology and Medical Embryology, Sapienza University of Rome, 00161 Rome, ItalyIstituto Pasteur-Fondazione Cenci Bolognetti, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Histology and Medical Embryology, Sapienza University of Rome, 00161 Rome, ItalyIstituto Pasteur-Fondazione Cenci Bolognetti, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Histology and Medical Embryology, Sapienza University of Rome, 00161 Rome, ItalyIstituto Dermopatico dell’Immacolata (IDI-IRCCS), 00167 Rome, ItalyIstituto Pasteur-Fondazione Cenci Bolognetti, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Histology and Medical Embryology, Sapienza University of Rome, 00161 Rome, ItalyIstituto Pasteur-Fondazione Cenci Bolognetti, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Histology and Medical Embryology, Sapienza University of Rome, 00161 Rome, ItalyDifferent stressful conditions such as hypoxia, nutrient deprivation, pH changes, or reduced vascularization, potentially able to act as growth-limiting factors for tumor cells, activate the unfolded protein response (UPR). UPR is therefore involved in tumor growth and adaptation to severe environments and is generally cytoprotective in cancer. The present review describes the molecular mechanisms underlying UPR and able to promote survival and proliferation in cancer. The critical role of UPR activation in tumor growth promotion is discussed in detail for a few paradigmatic tumors such as prostate cancer and melanoma.http://dx.doi.org/10.1155/2015/417281 |
spellingShingle | Claudia Giampietri Simonetta Petrungaro Silvia Conti Antonio Facchiano Antonio Filippini Elio Ziparo Cancer Microenvironment and Endoplasmic Reticulum Stress Response Mediators of Inflammation |
title | Cancer Microenvironment and Endoplasmic Reticulum Stress Response |
title_full | Cancer Microenvironment and Endoplasmic Reticulum Stress Response |
title_fullStr | Cancer Microenvironment and Endoplasmic Reticulum Stress Response |
title_full_unstemmed | Cancer Microenvironment and Endoplasmic Reticulum Stress Response |
title_short | Cancer Microenvironment and Endoplasmic Reticulum Stress Response |
title_sort | cancer microenvironment and endoplasmic reticulum stress response |
url | http://dx.doi.org/10.1155/2015/417281 |
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