Cancer Microenvironment and Endoplasmic Reticulum Stress Response

Different stressful conditions such as hypoxia, nutrient deprivation, pH changes, or reduced vascularization, potentially able to act as growth-limiting factors for tumor cells, activate the unfolded protein response (UPR). UPR is therefore involved in tumor growth and adaptation to severe environme...

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Main Authors: Claudia Giampietri, Simonetta Petrungaro, Silvia Conti, Antonio Facchiano, Antonio Filippini, Elio Ziparo
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2015/417281
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author Claudia Giampietri
Simonetta Petrungaro
Silvia Conti
Antonio Facchiano
Antonio Filippini
Elio Ziparo
author_facet Claudia Giampietri
Simonetta Petrungaro
Silvia Conti
Antonio Facchiano
Antonio Filippini
Elio Ziparo
author_sort Claudia Giampietri
collection DOAJ
description Different stressful conditions such as hypoxia, nutrient deprivation, pH changes, or reduced vascularization, potentially able to act as growth-limiting factors for tumor cells, activate the unfolded protein response (UPR). UPR is therefore involved in tumor growth and adaptation to severe environments and is generally cytoprotective in cancer. The present review describes the molecular mechanisms underlying UPR and able to promote survival and proliferation in cancer. The critical role of UPR activation in tumor growth promotion is discussed in detail for a few paradigmatic tumors such as prostate cancer and melanoma.
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institution Kabale University
issn 0962-9351
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language English
publishDate 2015-01-01
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series Mediators of Inflammation
spelling doaj-art-d6ce7e930cb140548fbfb6b2b37c9a992025-02-03T00:59:34ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/417281417281Cancer Microenvironment and Endoplasmic Reticulum Stress ResponseClaudia Giampietri0Simonetta Petrungaro1Silvia Conti2Antonio Facchiano3Antonio Filippini4Elio Ziparo5Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Histology and Medical Embryology, Sapienza University of Rome, 00161 Rome, ItalyIstituto Pasteur-Fondazione Cenci Bolognetti, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Histology and Medical Embryology, Sapienza University of Rome, 00161 Rome, ItalyIstituto Pasteur-Fondazione Cenci Bolognetti, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Histology and Medical Embryology, Sapienza University of Rome, 00161 Rome, ItalyIstituto Dermopatico dell’Immacolata (IDI-IRCCS), 00167 Rome, ItalyIstituto Pasteur-Fondazione Cenci Bolognetti, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Histology and Medical Embryology, Sapienza University of Rome, 00161 Rome, ItalyIstituto Pasteur-Fondazione Cenci Bolognetti, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Histology and Medical Embryology, Sapienza University of Rome, 00161 Rome, ItalyDifferent stressful conditions such as hypoxia, nutrient deprivation, pH changes, or reduced vascularization, potentially able to act as growth-limiting factors for tumor cells, activate the unfolded protein response (UPR). UPR is therefore involved in tumor growth and adaptation to severe environments and is generally cytoprotective in cancer. The present review describes the molecular mechanisms underlying UPR and able to promote survival and proliferation in cancer. The critical role of UPR activation in tumor growth promotion is discussed in detail for a few paradigmatic tumors such as prostate cancer and melanoma.http://dx.doi.org/10.1155/2015/417281
spellingShingle Claudia Giampietri
Simonetta Petrungaro
Silvia Conti
Antonio Facchiano
Antonio Filippini
Elio Ziparo
Cancer Microenvironment and Endoplasmic Reticulum Stress Response
Mediators of Inflammation
title Cancer Microenvironment and Endoplasmic Reticulum Stress Response
title_full Cancer Microenvironment and Endoplasmic Reticulum Stress Response
title_fullStr Cancer Microenvironment and Endoplasmic Reticulum Stress Response
title_full_unstemmed Cancer Microenvironment and Endoplasmic Reticulum Stress Response
title_short Cancer Microenvironment and Endoplasmic Reticulum Stress Response
title_sort cancer microenvironment and endoplasmic reticulum stress response
url http://dx.doi.org/10.1155/2015/417281
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