A Classical Manifestation of Eosinophilic Granulomatosis with Polyangiitis with an Unusual Catastrophic Outcome
A 57-year-old male patient, with a known case of bronchial asthma presented with acute dyspnea, cough with expectoration, fever, severe myalgia, and pedal edema. On physical examination, he had tachypnea, high temperature, bilateral polyphonic rhonchi, audible wheeze, and asymmetric sensory and moto...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-10-01
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| Series: | Clinical Dermatology Review |
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| Online Access: | https://journals.lww.com/10.4103/cdr.cdr_131_23 |
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| author | Balachandra S Bhat Niha Fathima Imthiaz Manjunath M. Shenoy MH Shariff |
| author_facet | Balachandra S Bhat Niha Fathima Imthiaz Manjunath M. Shenoy MH Shariff |
| author_sort | Balachandra S Bhat |
| collection | DOAJ |
| description | A 57-year-old male patient, with a known case of bronchial asthma presented with acute dyspnea, cough with expectoration, fever, severe myalgia, and pedal edema. On physical examination, he had tachypnea, high temperature, bilateral polyphonic rhonchi, audible wheeze, and asymmetric sensory and motor neuropathy. Cutaneous examination revealed multiple palpable purpuric lesions with few hemorrhagic bullae and crusted erosions distributed symmetrically over bilateral limbs suggestive of cutaneous small vessel vasculitis. Investigations showed elevated total counts, eosinophilia, deranged electrolytes, and abnormal liver and renal function tests. Histopathology revealed eosinophilic predominant vasculitis. Testing for perinuclear anti-cytoplasmic antibody was positive. A diagnosis of eosinophilic granulomatosis with polyangiitis (Churg–Strauss disease) was thus confirmed. The patient succumbed in 2 weeks due to multi-organ failure. All the characteristic findings were found in our patient, but a fatal outcome in a very short period after diagnosis was an unusual presentation. |
| format | Article |
| id | doaj-art-d6c7664124a94ddca78768233a7e5dd0 |
| institution | OA Journals |
| issn | 2542-551X 2542-5528 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Clinical Dermatology Review |
| spelling | doaj-art-d6c7664124a94ddca78768233a7e5dd02025-08-20T02:17:59ZengWolters Kluwer Medknow PublicationsClinical Dermatology Review2542-551X2542-55282024-10-018436837010.4103/cdr.cdr_131_23A Classical Manifestation of Eosinophilic Granulomatosis with Polyangiitis with an Unusual Catastrophic OutcomeBalachandra S BhatNiha Fathima ImthiazManjunath M. ShenoyMH ShariffA 57-year-old male patient, with a known case of bronchial asthma presented with acute dyspnea, cough with expectoration, fever, severe myalgia, and pedal edema. On physical examination, he had tachypnea, high temperature, bilateral polyphonic rhonchi, audible wheeze, and asymmetric sensory and motor neuropathy. Cutaneous examination revealed multiple palpable purpuric lesions with few hemorrhagic bullae and crusted erosions distributed symmetrically over bilateral limbs suggestive of cutaneous small vessel vasculitis. Investigations showed elevated total counts, eosinophilia, deranged electrolytes, and abnormal liver and renal function tests. Histopathology revealed eosinophilic predominant vasculitis. Testing for perinuclear anti-cytoplasmic antibody was positive. A diagnosis of eosinophilic granulomatosis with polyangiitis (Churg–Strauss disease) was thus confirmed. The patient succumbed in 2 weeks due to multi-organ failure. All the characteristic findings were found in our patient, but a fatal outcome in a very short period after diagnosis was an unusual presentation.https://journals.lww.com/10.4103/cdr.cdr_131_23bronchial asthmacutaneous small vessel vasculitiseosinophiliaeosinophilic granulomatosis with polyangiitis |
| spellingShingle | Balachandra S Bhat Niha Fathima Imthiaz Manjunath M. Shenoy MH Shariff A Classical Manifestation of Eosinophilic Granulomatosis with Polyangiitis with an Unusual Catastrophic Outcome Clinical Dermatology Review bronchial asthma cutaneous small vessel vasculitis eosinophilia eosinophilic granulomatosis with polyangiitis |
| title | A Classical Manifestation of Eosinophilic Granulomatosis with Polyangiitis with an Unusual Catastrophic Outcome |
| title_full | A Classical Manifestation of Eosinophilic Granulomatosis with Polyangiitis with an Unusual Catastrophic Outcome |
| title_fullStr | A Classical Manifestation of Eosinophilic Granulomatosis with Polyangiitis with an Unusual Catastrophic Outcome |
| title_full_unstemmed | A Classical Manifestation of Eosinophilic Granulomatosis with Polyangiitis with an Unusual Catastrophic Outcome |
| title_short | A Classical Manifestation of Eosinophilic Granulomatosis with Polyangiitis with an Unusual Catastrophic Outcome |
| title_sort | classical manifestation of eosinophilic granulomatosis with polyangiitis with an unusual catastrophic outcome |
| topic | bronchial asthma cutaneous small vessel vasculitis eosinophilia eosinophilic granulomatosis with polyangiitis |
| url | https://journals.lww.com/10.4103/cdr.cdr_131_23 |
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