Novel glucose-lowering agents that benefit diabetic foot: icing on the cake
The prevalence of diabetes mellitus is increasing and is linked to several complications, including diabetic foot. Novel glucose-lowering agents are sought that also have beneficial effects in reducing diabetic complications. Among the novel glucose-lowering agents demonstrating clinical promise, th...
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| Format: | Article |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1581403/full |
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| author | Qin Li Shiyan Yu Shunli Rui Xiaobu Lin Yi Yuan David G. Armstrong Yi Xu Yi Xu Wuquan Deng Wuquan Deng |
| author_facet | Qin Li Shiyan Yu Shunli Rui Xiaobu Lin Yi Yuan David G. Armstrong Yi Xu Yi Xu Wuquan Deng Wuquan Deng |
| author_sort | Qin Li |
| collection | DOAJ |
| description | The prevalence of diabetes mellitus is increasing and is linked to several complications, including diabetic foot. Novel glucose-lowering agents are sought that also have beneficial effects in reducing diabetic complications. Among the novel glucose-lowering agents demonstrating clinical promise, three classes stand out: dipeptidyl peptidase-4 inhibitors (DPP-4is), glucagon-like peptide-1 receptor agonists (GLP-1RAs), and sodium-glucose cotransporter-2 inhibitors (SGLT2is). Some of these agents provide cardiovascular and kidney benefits, and there is evidence suggesting they also offer protective effects against diabetic foot complications. In this review, we summarize the preclinical and clinical evidence proof these three glucose-lowering agents for diabetic foot, highlighting their potential in enhancing diabetic wound healing and limb preservation. In conclusion, existing available trials have shown that certain DPP-4is and GLP-1RAs possess protective effects against diabetic foot conditions. However, SGLT2is have not demonstrated a significant protective effect. We encourage larger-scale studies on the protective effects of these three types of drugs for diabetic foot to guide physicians in providing personalized treatment strategies, achieving blood glucose targets, and promoting the healing of chronic wounds in patients. |
| format | Article |
| id | doaj-art-d6c63c36b55d48559c5a6ae6c261ea50 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-d6c63c36b55d48559c5a6ae6c261ea502025-08-20T03:33:02ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-07-011610.3389/fendo.2025.15814031581403Novel glucose-lowering agents that benefit diabetic foot: icing on the cakeQin Li0Shiyan Yu1Shunli Rui2Xiaobu Lin3Yi Yuan4David G. Armstrong5Yi Xu6Yi Xu7Wuquan Deng8Wuquan Deng9Department of Endocrinology and Diabetic Foot Center, Chongqing University Central Hospital, Chongqing Emergency Medical Centre, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Endocrinology and Diabetic Foot Center, Chongqing University Central Hospital, Chongqing Emergency Medical Centre, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Endocrinology and Diabetic Foot Center, Chongqing University Central Hospital, Chongqing Emergency Medical Centre, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Endocrinology and Diabetic Foot Center, Chongqing University Central Hospital, Chongqing Emergency Medical Centre, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Endocrinology and Diabetic Foot Center, Chongqing University Central Hospital, Chongqing Emergency Medical Centre, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA, United StatesDepartment of Endocrinology and Diabetic Foot Center, Chongqing University Central Hospital, Chongqing Emergency Medical Centre, School of Medicine, Chongqing University, Chongqing, ChinaChongqing Liang Jiang New Area Traditional Chinese Medicine Hospital, Chongqing, ChinaDepartment of Endocrinology and Diabetic Foot Center, Chongqing University Central Hospital, Chongqing Emergency Medical Centre, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Population Health Sciences, King's College London, London, United KingdomThe prevalence of diabetes mellitus is increasing and is linked to several complications, including diabetic foot. Novel glucose-lowering agents are sought that also have beneficial effects in reducing diabetic complications. Among the novel glucose-lowering agents demonstrating clinical promise, three classes stand out: dipeptidyl peptidase-4 inhibitors (DPP-4is), glucagon-like peptide-1 receptor agonists (GLP-1RAs), and sodium-glucose cotransporter-2 inhibitors (SGLT2is). Some of these agents provide cardiovascular and kidney benefits, and there is evidence suggesting they also offer protective effects against diabetic foot complications. In this review, we summarize the preclinical and clinical evidence proof these three glucose-lowering agents for diabetic foot, highlighting their potential in enhancing diabetic wound healing and limb preservation. In conclusion, existing available trials have shown that certain DPP-4is and GLP-1RAs possess protective effects against diabetic foot conditions. However, SGLT2is have not demonstrated a significant protective effect. We encourage larger-scale studies on the protective effects of these three types of drugs for diabetic foot to guide physicians in providing personalized treatment strategies, achieving blood glucose targets, and promoting the healing of chronic wounds in patients.https://www.frontiersin.org/articles/10.3389/fendo.2025.1581403/fulldiabetic footnovel glucose-lowering agentsdipeptidyl peptidase-4 inhibitorsglucagon-like peptide-1 receptor agonistssodium-glucose cotransporter-2 inhibitors |
| spellingShingle | Qin Li Shiyan Yu Shunli Rui Xiaobu Lin Yi Yuan David G. Armstrong Yi Xu Yi Xu Wuquan Deng Wuquan Deng Novel glucose-lowering agents that benefit diabetic foot: icing on the cake Frontiers in Endocrinology diabetic foot novel glucose-lowering agents dipeptidyl peptidase-4 inhibitors glucagon-like peptide-1 receptor agonists sodium-glucose cotransporter-2 inhibitors |
| title | Novel glucose-lowering agents that benefit diabetic foot: icing on the cake |
| title_full | Novel glucose-lowering agents that benefit diabetic foot: icing on the cake |
| title_fullStr | Novel glucose-lowering agents that benefit diabetic foot: icing on the cake |
| title_full_unstemmed | Novel glucose-lowering agents that benefit diabetic foot: icing on the cake |
| title_short | Novel glucose-lowering agents that benefit diabetic foot: icing on the cake |
| title_sort | novel glucose lowering agents that benefit diabetic foot icing on the cake |
| topic | diabetic foot novel glucose-lowering agents dipeptidyl peptidase-4 inhibitors glucagon-like peptide-1 receptor agonists sodium-glucose cotransporter-2 inhibitors |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1581403/full |
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