Capnocytophaga ochracea detected in cerebrospinal fluid of a meningioma patient: a case report
Abstract Capnocytophaga ochracea (C. ochracea) is a species of Gram-negative and facultative anaerobic bacterium. It was first reported in 1979 and isolated from both healthy and diseased sites in the oral flora. The bacteria can cause septicemia, endocarditis, endometritis, blepharoconjunctivitis a...
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BMC
2025-02-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-025-10641-y |
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| author | Le Zhang Jingyi Hu Ying Xin Han Cheng Yan Yan Qin Wang |
| author_facet | Le Zhang Jingyi Hu Ying Xin Han Cheng Yan Yan Qin Wang |
| author_sort | Le Zhang |
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| description | Abstract Capnocytophaga ochracea (C. ochracea) is a species of Gram-negative and facultative anaerobic bacterium. It was first reported in 1979 and isolated from both healthy and diseased sites in the oral flora. The bacteria can cause septicemia, endocarditis, endometritis, blepharoconjunctivitis and other infections. Herein, we present the first cerebrospinal fluid (CSF) infection case caused by C. ochracea in humans. Gram-negative fusiform, non-spore forming rods were detected in an anaerobic bottle of CSF culture obtained from a 50-year-old man who had been hospitalized for meningioma in Tianjin Huanhu Hospital. Although the organism could not be identified using a conventional method, it was finally identified as C. ochracea based on the results of metagenomics next generation sequencing, matrix-assisted laser desorption ionization time-of-flight mass spectrometry and 16 S rDNA sequencing analysis. Subsequently, Streptococcus oralis was also detected in the CSF of the patient. The patient was treated with meropenem and vancomycin, and the infection was well controlled. The clinically rare C. ochracea can be pathogenic in central nervous system of humans. |
| format | Article |
| id | doaj-art-d6bebbb7a3df4d2dbf9c2fc7d5668ab7 |
| institution | DOAJ |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Infectious Diseases |
| spelling | doaj-art-d6bebbb7a3df4d2dbf9c2fc7d5668ab72025-08-20T03:10:50ZengBMCBMC Infectious Diseases1471-23342025-02-012511510.1186/s12879-025-10641-yCapnocytophaga ochracea detected in cerebrospinal fluid of a meningioma patient: a case reportLe Zhang0Jingyi Hu1Ying Xin2Han Cheng3Yan Yan4Qin Wang5Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical UniversityDepartment of Clinical Laboratory, Tianjin Huanhu HospitalDepartment of Clinical Laboratory, Tianjin Huanhu HospitalDepartment of Clinical Laboratory, Tianjin Huanhu HospitalClinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical UniversityClinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical UniversityAbstract Capnocytophaga ochracea (C. ochracea) is a species of Gram-negative and facultative anaerobic bacterium. It was first reported in 1979 and isolated from both healthy and diseased sites in the oral flora. The bacteria can cause septicemia, endocarditis, endometritis, blepharoconjunctivitis and other infections. Herein, we present the first cerebrospinal fluid (CSF) infection case caused by C. ochracea in humans. Gram-negative fusiform, non-spore forming rods were detected in an anaerobic bottle of CSF culture obtained from a 50-year-old man who had been hospitalized for meningioma in Tianjin Huanhu Hospital. Although the organism could not be identified using a conventional method, it was finally identified as C. ochracea based on the results of metagenomics next generation sequencing, matrix-assisted laser desorption ionization time-of-flight mass spectrometry and 16 S rDNA sequencing analysis. Subsequently, Streptococcus oralis was also detected in the CSF of the patient. The patient was treated with meropenem and vancomycin, and the infection was well controlled. The clinically rare C. ochracea can be pathogenic in central nervous system of humans.https://doi.org/10.1186/s12879-025-10641-yCapnocytophaga ochraceaCSFInfectionCase reportOral flora |
| spellingShingle | Le Zhang Jingyi Hu Ying Xin Han Cheng Yan Yan Qin Wang Capnocytophaga ochracea detected in cerebrospinal fluid of a meningioma patient: a case report BMC Infectious Diseases Capnocytophaga ochracea CSF Infection Case report Oral flora |
| title | Capnocytophaga ochracea detected in cerebrospinal fluid of a meningioma patient: a case report |
| title_full | Capnocytophaga ochracea detected in cerebrospinal fluid of a meningioma patient: a case report |
| title_fullStr | Capnocytophaga ochracea detected in cerebrospinal fluid of a meningioma patient: a case report |
| title_full_unstemmed | Capnocytophaga ochracea detected in cerebrospinal fluid of a meningioma patient: a case report |
| title_short | Capnocytophaga ochracea detected in cerebrospinal fluid of a meningioma patient: a case report |
| title_sort | capnocytophaga ochracea detected in cerebrospinal fluid of a meningioma patient a case report |
| topic | Capnocytophaga ochracea CSF Infection Case report Oral flora |
| url | https://doi.org/10.1186/s12879-025-10641-y |
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