Presepsin in Hepatic Pathology: Bridging the Gap in Early Sepsis Detection
Sepsis represents a major cause of mortality, especially among patients with liver cirrhosis, who are at increased risk due to immune dysfunction, gut-derived bacterial translocation, and altered hepatic metabolism. Traditional biomarkers such as C-reactive protein (CRP), procalcitonin (PCT), and in...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-07-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/15/15/1871 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849770542389788672 |
|---|---|
| author | Dana-Maria Bilous Mihai Ciocîrlan Cătălina Vlăduț Carmen-Georgeta Fierbințeanu-Braticevici |
| author_facet | Dana-Maria Bilous Mihai Ciocîrlan Cătălina Vlăduț Carmen-Georgeta Fierbințeanu-Braticevici |
| author_sort | Dana-Maria Bilous |
| collection | DOAJ |
| description | Sepsis represents a major cause of mortality, especially among patients with liver cirrhosis, who are at increased risk due to immune dysfunction, gut-derived bacterial translocation, and altered hepatic metabolism. Traditional biomarkers such as C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) often have reduced diagnostic reliability in this subgroup, due to impaired liver and renal function. Presepsin, a soluble fragment of CD14 released during phagocytic activation, has emerged as a promising biomarker for early sepsis detection. This systematic review explores the diagnostic and prognostic utility of presepsin in cirrhotic and non-cirrhotic patients with suspected infection. Data from multiple clinical studies indicate that presepsin levels correlate with infection severity and clinical scores such as SOFA and APACHE II. In cirrhotic patients, presepsin demonstrates superior sensitivity and specificity compared to conventional biomarkers, maintaining diagnostic value despite hepatic dysfunction. Its utility extends to differentiating bacterial infections from fungal infections and monitoring treatment response. While preliminary evidence is compelling, further prospective, multicenter studies are required to validate its integration into standard care algorithms. Presepsin may become a valuable addition to clinical decision-making tools, particularly in hepatology-focused sepsis management. |
| format | Article |
| id | doaj-art-d6bbbe88f6004c17a3cdf529140555aa |
| institution | DOAJ |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-d6bbbe88f6004c17a3cdf529140555aa2025-08-20T03:02:58ZengMDPI AGDiagnostics2075-44182025-07-011515187110.3390/diagnostics15151871Presepsin in Hepatic Pathology: Bridging the Gap in Early Sepsis DetectionDana-Maria Bilous0Mihai Ciocîrlan1Cătălina Vlăduț2Carmen-Georgeta Fierbințeanu-Braticevici3Gastroenterology Department, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaGastroenterology Department, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaGastroenterology Department, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaGastroenterology Department, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaSepsis represents a major cause of mortality, especially among patients with liver cirrhosis, who are at increased risk due to immune dysfunction, gut-derived bacterial translocation, and altered hepatic metabolism. Traditional biomarkers such as C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) often have reduced diagnostic reliability in this subgroup, due to impaired liver and renal function. Presepsin, a soluble fragment of CD14 released during phagocytic activation, has emerged as a promising biomarker for early sepsis detection. This systematic review explores the diagnostic and prognostic utility of presepsin in cirrhotic and non-cirrhotic patients with suspected infection. Data from multiple clinical studies indicate that presepsin levels correlate with infection severity and clinical scores such as SOFA and APACHE II. In cirrhotic patients, presepsin demonstrates superior sensitivity and specificity compared to conventional biomarkers, maintaining diagnostic value despite hepatic dysfunction. Its utility extends to differentiating bacterial infections from fungal infections and monitoring treatment response. While preliminary evidence is compelling, further prospective, multicenter studies are required to validate its integration into standard care algorithms. Presepsin may become a valuable addition to clinical decision-making tools, particularly in hepatology-focused sepsis management.https://www.mdpi.com/2075-4418/15/15/1871presepsinsepsisliver cirrhosis |
| spellingShingle | Dana-Maria Bilous Mihai Ciocîrlan Cătălina Vlăduț Carmen-Georgeta Fierbințeanu-Braticevici Presepsin in Hepatic Pathology: Bridging the Gap in Early Sepsis Detection Diagnostics presepsin sepsis liver cirrhosis |
| title | Presepsin in Hepatic Pathology: Bridging the Gap in Early Sepsis Detection |
| title_full | Presepsin in Hepatic Pathology: Bridging the Gap in Early Sepsis Detection |
| title_fullStr | Presepsin in Hepatic Pathology: Bridging the Gap in Early Sepsis Detection |
| title_full_unstemmed | Presepsin in Hepatic Pathology: Bridging the Gap in Early Sepsis Detection |
| title_short | Presepsin in Hepatic Pathology: Bridging the Gap in Early Sepsis Detection |
| title_sort | presepsin in hepatic pathology bridging the gap in early sepsis detection |
| topic | presepsin sepsis liver cirrhosis |
| url | https://www.mdpi.com/2075-4418/15/15/1871 |
| work_keys_str_mv | AT danamariabilous presepsininhepaticpathologybridgingthegapinearlysepsisdetection AT mihaiciocirlan presepsininhepaticpathologybridgingthegapinearlysepsisdetection AT catalinavladut presepsininhepaticpathologybridgingthegapinearlysepsisdetection AT carmengeorgetafierbinteanubraticevici presepsininhepaticpathologybridgingthegapinearlysepsisdetection |